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Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. Additionally we are shipping Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Kits (6) and Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Proteins (4) and many more products for this protein.
Showing 10 out of 37 products:
Human Polyclonal SDHD Primary Antibody for EIA, FACS - ABIN954695
Gill, Benn, Chou, Clarkson, Muljono, Meyer-Rochow, Richardson, Sidhu, Robinson, Clifton-Bligh: Immunohistochemistry for SDHB triages genetic testing of SDHB, SDHC, and SDHD in paraganglioma-pheochromocytoma syndromes. in Human pathology 2010
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Human Polyclonal SDHD Primary Antibody for EIA, IF - ABIN1449927
Knudson: Genetics of human cancer. in Annual review of genetics 1987
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Human Polyclonal SDHD Primary Antibody for FACS, IF - ABIN656089
Milosevic, Lundquist, Cradic, Vidal-Folch, Huynh, Pacak, Grebe: Development and validation of a comprehensive mutation and deletion detection assay for SDHB, SDHC, and SDHD. in Clinical biochemistry 2010
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Human Polyclonal SDHD Primary Antibody for IHC, IHC (p) - ABIN4352365
Chang, Hsieh, Chang, Wang, Lin, Wang, Lou, Teng: Instability of succinate dehydrogenase in SDHD polymorphism connects reactive oxygen species production to nuclear and mitochondrial genomic mutations in yeast. in Antioxidants & redox signaling 2015
Mortality rates and survival in a Dutch cohort of SDHD variant carriers does not differ from that of the general Dutch population.
Melanomas harbor recurrent SDHD promoter mutations, which occur primarily as C>T alterations in UV-exposed melanomas.
Loss of SDH (show SARDH Antibodies) activity leads to changes in the metabolism of non-essential amino acids.
significant association with overall survival were confirmed for SDHC (show SDHC Antibodies) gene, SDHD gene and FH gene ... SDHC (show SDHC Antibodies) gene and FH gene were the primary factors contributing to the different overall survival time of colorectal carcinoma
15 YEARS OF PARAGANGLIOMA: Genetics and mechanism of pheochromocytoma-paraganglioma syndromes characterized by germline SDHB (show SDHB Antibodies) and SDHD mutations
Metabolic sensors via Sirt3 (show SIRT3 Antibodies) maximize the cellular reserve respiratory capacity through activating mitochondrial complex II, which enhances cell survival after hypoxia.
Data indicate that double pathogenic mutations in the succinate dehydrogenase complex subunit D (SDHD) gene is associated with the aggressive paraganglioma syndrome type 1 (PGL1) phenotype.
suggested that SDHD mutation may enhance the overexpression of miR (show MLXIP Antibodies)-101 in malignant tumors and miR (show MLXIP Antibodies)-101 may be a potential diagnostic biomarker for malignant pheochromocytoma and benign pheochromocytoma
Hereditary pheochromocytoma / paraganglioma associated with SDHD gene mutations has more aggressive course,bilateral adrenal involvement, higher recurrence rate, younger age at disease manifestations.
Autosomal dominant susceptibility for Paraganglioma is modified by imprinting and mutations in the SDHD gene cause Paragangliomas only when the mutation is inherited from father.
The expression and sequencing of SDHD and single nucleotide polymorphisms of the gene are reported.
Loss of SDH (show SDS Antibodies) activity leads to changes in the metabolism of non-essential amino acids.
In mice with conditional knockout of Sdhd, we found that the Cdkn1a (show CDKN1A Antibodies) gene was up-regulated in kidney and adrenal. This gene encodes the cyclin-dependent kinase (show CDK1 Antibodies) inhibitor p21(WAF1/Cip1 (show CDKN1A Antibodies)), a factor implicated in cell cycle, senescence, and cancer.
complete loss of SdhD is not sufficient to induce tumorigenesis in mice
SDHD is required for the formation of a stable mitochondrial complex II, and it is selectively important for hypoxic pulmonary vasoconstriction of intra-acinar vessels.
Knockout of Sdhd in the mouse does not result in a disease phenotype; H19 (show NCKAP1 Antibodies) may not be an initiator of PGL (show PGLS Antibodies)/PC tumorigenesis
Mitochondrial Sdhd is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to cell hypoxia.
This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants.
succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
, succinate-ubiquinone oxidoreductase cytochrome b small subunit
, succinate-ubiquinone reductase membrane anchor subunit
, Succinate dehydrogenase complex subunit D
, Succinate-ubiquinone oxidoreductase cytochrome b small subunit
, Succinate-ubiquinone reductase membrane anchor subunit
, succinate dehydrogenase complex subunit D