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anti-Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) Antibodies

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. Additionally we are shipping Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Kits (6) and Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SDHD 6392 O14521
SDHD 66925 Q9CXV1
SDHD 363061 Q6PCT8
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Top anti-Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB SDHD Antibody (N-term) (ABIN656089) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB Confocal Immunofluorescent analysis of SDHD Antibody (N-term) Cat.-No AP53823PU-N with Hela cell followed by Alexa Fluor 488-conjugated Goat anti-Rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human kidney tissue stained with SDHD Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of SDHD Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of SDHD in EL4 cells with SDHD antibody at 2.5 ug/mL. Western blot analysis of SDHD in EL4 cell lysate with SDHD antibody at (A) 1 and (B) 2 ug/mL. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-SDHD Polyclonal Antibody, Unconjugated (ABIN751918) at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain labeled with Anti SDHD Polyclonal Antibody, Unconjugated (ABIN751918) followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Biotin IHC (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

SDHD Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine)


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Top referenced anti-Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Antibodies

  1. Human Polyclonal SDHD Primary Antibody for EIA, FACS - ABIN954695 : Gill, Benn, Chou, Clarkson, Muljono, Meyer-Rochow, Richardson, Sidhu, Robinson, Clifton-Bligh: Immunohistochemistry for SDHB triages genetic testing of SDHB, SDHC, and SDHD in paraganglioma-pheochromocytoma syndromes. in Human pathology 2010 (PubMed)
    Show all 4 references for ABIN954695

  2. Human Polyclonal SDHD Primary Antibody for EIA, IF - ABIN1449927 : Knudson: Genetics of human cancer. in Annual review of genetics 1987 (PubMed)
    Show all 4 references for ABIN1449927

  3. Human Polyclonal SDHD Primary Antibody for FACS, IF - ABIN656089 : Milosevic, Lundquist, Cradic, Vidal-Folch, Huynh, Pacak, Grebe: Development and validation of a comprehensive mutation and deletion detection assay for SDHB, SDHC, and SDHD. in Clinical biochemistry 2010 (PubMed)
    Show all 2 references for ABIN656089

More Antibodies against Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Interaction Partners

Human Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) interaction partners

  1. Mortality rates and survival in a Dutch cohort of SDHD variant carriers does not differ from that of the general Dutch population.

  2. Melanomas harbor recurrent SDHD promoter mutations, which occur primarily as C>T alterations in UV-exposed melanomas.

  3. Loss of SDH (show SARDH Antibodies) activity leads to changes in the metabolism of non-essential amino acids.

  4. significant association with overall survival were confirmed for SDHC (show SDHC Antibodies) gene, SDHD gene and FH gene ... SDHC (show SDHC Antibodies) gene and FH gene were the primary factors contributing to the different overall survival time of colorectal carcinoma

  5. 15 YEARS OF PARAGANGLIOMA: Genetics and mechanism of pheochromocytoma-paraganglioma syndromes characterized by germline SDHB (show SDHB Antibodies) and SDHD mutations

  6. Metabolic sensors via Sirt3 (show SIRT3 Antibodies) maximize the cellular reserve respiratory capacity through activating mitochondrial complex II, which enhances cell survival after hypoxia.

  7. Data indicate that double pathogenic mutations in the succinate dehydrogenase complex subunit D (SDHD) gene is associated with the aggressive paraganglioma syndrome type 1 (PGL1) phenotype.

  8. suggested that SDHD mutation may enhance the overexpression of miR (show MLXIP Antibodies)-101 in malignant tumors and miR (show MLXIP Antibodies)-101 may be a potential diagnostic biomarker for malignant pheochromocytoma and benign pheochromocytoma

  9. Hereditary pheochromocytoma / paraganglioma associated with SDHD gene mutations has more aggressive course,bilateral adrenal involvement, higher recurrence rate, younger age at disease manifestations.

  10. Autosomal dominant susceptibility for Paraganglioma is modified by imprinting and mutations in the SDHD gene cause Paragangliomas only when the mutation is inherited from father.

Pig (Porcine) Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) interaction partners

  1. The expression and sequencing of SDHD and single nucleotide polymorphisms of the gene are reported.

Mouse (Murine) Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) interaction partners

  1. Loss of SDH (show SDS Antibodies) activity leads to changes in the metabolism of non-essential amino acids.

  2. In mice with conditional knockout of Sdhd, we found that the Cdkn1a (show CDKN1A Antibodies) gene was up-regulated in kidney and adrenal. This gene encodes the cyclin-dependent kinase (show CDK1 Antibodies) inhibitor p21(WAF1/Cip1 (show CDKN1A Antibodies)), a factor implicated in cell cycle, senescence, and cancer.

  3. complete loss of SdhD is not sufficient to induce tumorigenesis in mice

  4. SDHD is required for the formation of a stable mitochondrial complex II, and it is selectively important for hypoxic pulmonary vasoconstriction of intra-acinar vessels.

  5. Knockout of Sdhd in the mouse does not result in a disease phenotype; H19 (show NCKAP1 Antibodies) may not be an initiator of PGL (show PGLS Antibodies)/PC tumorigenesis

  6. Mitochondrial Sdhd is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to cell hypoxia.

Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) Antigen Profile

Protein Summary

This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with SDHD

  • succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD) antibody
  • succinate dehydrogenase complex, subunit D, integral membrane protein (Sdhd) antibody
  • 3110001M13Rik antibody
  • AVLL5809 antibody
  • C78570 antibody
  • CBT1 antibody
  • CII-4 antibody
  • CII4 antibody
  • CWS3 antibody
  • CybS antibody
  • PGL antibody
  • PGL1 antibody
  • PRO19626 antibody
  • QPs3 antibody
  • SDH4 antibody

Protein level used designations for SDHD

succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial , succinate-ubiquinone oxidoreductase cytochrome b small subunit , succinate-ubiquinone reductase membrane anchor subunit , Succinate dehydrogenase complex subunit D , Succinate-ubiquinone oxidoreductase cytochrome b small subunit , Succinate-ubiquinone reductase membrane anchor subunit , succinate dehydrogenase complex subunit D , CII-4 , QPs3 , cybS

GENE ID SPECIES
6392 Homo sapiens
479438 Canis lupus familiaris
100048954 Sus scrofa
281481 Bos taurus
66925 Mus musculus
363061 Rattus norvegicus
419793 Gallus gallus
101111485 Ovis aries
100172275 Pongo abelii
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