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Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Proteins (SDHD)

SDHD encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. Additionally we are shipping Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Antibodies (36) and Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SDHD 6392 O14521
SDHD 66925 Q9CXV1
Rat SDHD SDHD 363061 Q6PCT8
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Top Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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SDHD Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) Interaction Partners

Human Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) interaction partners

  1. Mortality rates and survival in a Dutch cohort of SDHD variant carriers does not differ from that of the general Dutch population.

  2. Melanomas harbor recurrent SDHD promoter mutations, which occur primarily as C>T alterations in UV-exposed melanomas.

  3. Loss of SDH activity leads to changes in the metabolism of non-essential amino acids.

  4. significant association with overall survival were confirmed for SDHC (show SDHC Proteins) gene, SDHD gene and FH gene ... SDHC (show SDHC Proteins) gene and FH gene were the primary factors contributing to the different overall survival time of colorectal carcinoma

  5. 15 YEARS OF PARAGANGLIOMA: Genetics and mechanism of pheochromocytoma-paraganglioma syndromes characterized by germline SDHB (show SDHB Proteins) and SDHD mutations

  6. Metabolic sensors via Sirt3 (show SIRT3 Proteins) maximize the cellular reserve respiratory capacity through activating mitochondrial complex II, which enhances cell survival after hypoxia.

  7. Data indicate that double pathogenic mutations in the succinate dehydrogenase complex subunit D (SDHD) gene is associated with the aggressive paraganglioma syndrome type 1 (PGL1) phenotype.

  8. suggested that SDHD mutation may enhance the overexpression of miR (show MLXIP Proteins)-101 in malignant tumors and miR (show MLXIP Proteins)-101 may be a potential diagnostic biomarker for malignant pheochromocytoma and benign pheochromocytoma

  9. Hereditary pheochromocytoma / paraganglioma associated with SDHD gene mutations has more aggressive course,bilateral adrenal involvement, higher recurrence rate, younger age at disease manifestations.

  10. Autosomal dominant susceptibility for Paraganglioma is modified by imprinting and mutations in the SDHD gene cause Paragangliomas only when the mutation is inherited from father.

Pig (Porcine) Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) interaction partners

  1. The expression and sequencing of SDHD and single nucleotide polymorphisms of the gene are reported.

Mouse (Murine) Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) interaction partners

  1. Loss of SDH (show SDS Proteins) activity leads to changes in the metabolism of non-essential amino acids.

  2. In mice with conditional knockout of Sdhd, we found that the Cdkn1a (show CDKN1A Proteins) gene was up-regulated in kidney and adrenal. This gene encodes the cyclin-dependent kinase (show CDK1 Proteins) inhibitor p21(WAF1/Cip1 (show CDKN1A Proteins)), a factor implicated in cell cycle, senescence, and cancer.

  3. complete loss of SdhD is not sufficient to induce tumorigenesis in mice

  4. SDHD is required for the formation of a stable mitochondrial complex II, and it is selectively important for hypoxic pulmonary vasoconstriction of intra-acinar vessels.

  5. Knockout of Sdhd in the mouse does not result in a disease phenotype; H19 (show NCKAP1 Proteins) may not be an initiator of PGL (show PGLS Proteins)/PC tumorigenesis

  6. Mitochondrial Sdhd is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to cell hypoxia.

Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) Protein Profile

Protein Summary

This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with SDHD

  • succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD)
  • succinate dehydrogenase complex, subunit D, integral membrane protein (Sdhd)
  • 3110001M13Rik protein
  • AVLL5809 protein
  • C78570 protein
  • CBT1 protein
  • CII-4 protein
  • CII4 protein
  • CWS3 protein
  • CybS protein
  • PGL protein
  • PGL1 protein
  • PRO19626 protein
  • QPs3 protein
  • SDH4 protein

Protein level used designations for SDHD

succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial , succinate-ubiquinone oxidoreductase cytochrome b small subunit , succinate-ubiquinone reductase membrane anchor subunit , Succinate dehydrogenase complex subunit D , Succinate-ubiquinone oxidoreductase cytochrome b small subunit , Succinate-ubiquinone reductase membrane anchor subunit , succinate dehydrogenase complex subunit D , CII-4 , QPs3 , cybS

GENE ID SPECIES
6392 Homo sapiens
479438 Canis lupus familiaris
100048954 Sus scrofa
281481 Bos taurus
66925 Mus musculus
363061 Rattus norvegicus
419793 Gallus gallus
101111485 Ovis aries
100172275 Pongo abelii
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