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Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. Additionally we are shipping Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Proteins (13) and Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Kits (5) and many more products for this protein.
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Human Polyclonal SDHD Primary Antibody for IHC, IHC (p) - ABIN4352365
Chang, Hsieh, Chang, Wang, Lin, Wang, Lou, Teng: Instability of succinate dehydrogenase in SDHD polymorphism connects reactive oxygen species production to nuclear and mitochondrial genomic mutations in yeast. in Antioxidants & redox signaling 2015
Loss of SDHD gene is associated with paragangliomas.
promoter mutation seems to be a rare event in CM but SDHD lower expression might associate with worst prognostic features in CM
role for GABPA (show GABPA Antibodies)/B1 as the critical ETS (show ETS1 Antibodies) transcription factors deregulating SDHD expression in the context of highly recurrent promoter mutations in melanoma.
SDH (show SARDH Antibodies)-deficient gastrointestinal stromal tumors (GISTs) account for approximately 8% of gastric GISTs and are associated with a high rate of distant metastasis, regardless of conventional risk category.
For classification, tumors were characterized by SDHA (show SDHA Antibodies), B, C, or D (SDHX) mutations and other genetic and epigenetic alterations, including presence of mutations in germline
Heterozygous germline deletions of up to 104 kb in size were identified in SDHB (show SDHB Antibodies), SDHC (show SDHC Antibodies), SDHD and flanking genes in 20 paraganglioma-pheochromocytoma patients. The exact breakpoint could be determined in 16 paraganglioma-pheochromocytoma patients of which 15 were novel deletions
our study reveals a novel mechanism of crosstalk amongst SDHD, PTEN (show PTEN Antibodies) and autophagy pathways and their potential roles in thyroid carcinogenesis
According to international guidelines, SDHB (show SDHB Antibodies), SDHC (show SDHC Antibodies), and SDHD genetic testing were performed in this patient, but not SDHA (show SDHA Antibodies), which would have been prescribed only after surgery, in case of SDHA (show SDHA Antibodies) negative immunohistochemistry
Mortality rates and survival in a Dutch cohort of SDHD variant carriers does not differ from that of the general Dutch population.
Melanomas harbor recurrent SDHD promoter mutations, which occur primarily as C>T alterations in UV-exposed melanomas.
The expression and sequencing of SDHD and single nucleotide polymorphisms of the gene are reported.
the actual dependency of undifferentiated hematopoietic stem cells on mitochondrial function, we have performed an analysis of the hematopoiesis in a mouse mutant, named SDHD-ESR (show ESR1 Antibodies), with inducible deletion of the mitochondrial protein (show COX6B2 Antibodies)-encoding SdhD gene, is reported.
Loss of SDH (show SDS Antibodies) activity leads to changes in the metabolism of non-essential amino acids.
In mice with conditional knockout of Sdhd, we found that the Cdkn1a (show CDKN1A Antibodies) gene was up-regulated in kidney and adrenal. This gene encodes the cyclin-dependent kinase (show CDK1 Antibodies) inhibitor p21(WAF1/Cip1 (show CDKN1A Antibodies)), a factor implicated in cell cycle, senescence, and cancer.
complete loss of SdhD is not sufficient to induce tumorigenesis in mice
SDHD is required for the formation of a stable mitochondrial complex II, and it is selectively important for hypoxic pulmonary vasoconstriction of intra-acinar vessels.
Knockout of Sdhd in the mouse does not result in a disease phenotype; H19 (show NCKAP1 Antibodies) may not be an initiator of PGL (show PGLS Antibodies)/PC tumorigenesis
Mitochondrial Sdhd is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to cell hypoxia.
This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants.
succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
, succinate-ubiquinone oxidoreductase cytochrome b small subunit
, succinate-ubiquinone reductase membrane anchor subunit
, Succinate dehydrogenase complex subunit D
, Succinate-ubiquinone oxidoreductase cytochrome b small subunit
, Succinate-ubiquinone reductase membrane anchor subunit
, succinate dehydrogenase complex subunit D