anti-Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) Antibodies

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. Additionally we are shipping Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Proteins (13) and Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SDHD 6392 O14521
SDHD 66925 Q9CXV1
SDHD 363061 Q6PCT8
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Top anti-Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Antibodies at antibodies-online.com

Showing 10 out of 43 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB SDHD Antibody (N-term) (ABIN656089) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB Confocal Immunofluorescent analysis of SDHD Antibody (N-term) Cat.-No AP53823PU-N with Hela cell followed by Alexa Fluor 488-conjugated Goat anti-Rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human kidney tissue stained with SDHD Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of SDHD Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry-Paraffin: SDHD Antibody [NBP1-92372] Staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated EIA, IF, WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-SDHD Polyclonal Antibody, Unconjugated (ABIN751918) at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain labeled with Anti SDHD Polyclonal Antibody, Unconjugated (ABIN751918) followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of SDHD in EL4 cell lysate with SDHD antibody at (A) 1 and (B) 2 µg/mL. 0.1 mg Log in to see 2 to 3 Days
$340.00
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy5 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy7 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

SDHD Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine)


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Top referenced anti-Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Antibodies

  1. Human Polyclonal SDHD Primary Antibody for IHC, IHC (p) - ABIN4352365 : Chang, Hsieh, Chang, Wang, Lin, Wang, Lou, Teng: Instability of succinate dehydrogenase in SDHD polymorphism connects reactive oxygen species production to nuclear and mitochondrial genomic mutations in yeast. in Antioxidants & redox signaling 2015 (PubMed)

More Antibodies against Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Interaction Partners

Human Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) interaction partners

  1. Loss of SDHD gene is associated with paragangliomas.

  2. promoter mutation seems to be a rare event in CM but SDHD lower expression might associate with worst prognostic features in CM

  3. role for GABPA (show GABPA Antibodies)/B1 as the critical ETS (show ETS1 Antibodies) transcription factors deregulating SDHD expression in the context of highly recurrent promoter mutations in melanoma.

  4. SDH (show SARDH Antibodies)-deficient gastrointestinal stromal tumors (GISTs) account for approximately 8% of gastric GISTs and are associated with a high rate of distant metastasis, regardless of conventional risk category.

  5. For classification, tumors were characterized by SDHA (show SDHA Antibodies), B, C, or D (SDHX) mutations and other genetic and epigenetic alterations, including presence of mutations in germline

  6. Heterozygous germline deletions of up to 104 kb in size were identified in SDHB (show SDHB Antibodies), SDHC (show SDHC Antibodies), SDHD and flanking genes in 20 paraganglioma-pheochromocytoma patients. The exact breakpoint could be determined in 16 paraganglioma-pheochromocytoma patients of which 15 were novel deletions

  7. our study reveals a novel mechanism of crosstalk amongst SDHD, PTEN (show PTEN Antibodies) and autophagy pathways and their potential roles in thyroid carcinogenesis

  8. According to international guidelines, SDHB (show SDHB Antibodies), SDHC (show SDHC Antibodies), and SDHD genetic testing were performed in this patient, but not SDHA (show SDHA Antibodies), which would have been prescribed only after surgery, in case of SDHA (show SDHA Antibodies) negative immunohistochemistry

  9. Mortality rates and survival in a Dutch cohort of SDHD variant carriers does not differ from that of the general Dutch population.

  10. Melanomas harbor recurrent SDHD promoter mutations, which occur primarily as C>T alterations in UV-exposed melanomas.

Pig (Porcine) Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) interaction partners

  1. The expression and sequencing of SDHD and single nucleotide polymorphisms of the gene are reported.

Mouse (Murine) Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) interaction partners

  1. the actual dependency of undifferentiated hematopoietic stem cells on mitochondrial function, we have performed an analysis of the hematopoiesis in a mouse mutant, named SDHD-ESR (show ESR1 Antibodies), with inducible deletion of the mitochondrial protein (show COX6B2 Antibodies)-encoding SdhD gene, is reported.

  2. Loss of SDH (show SDS Antibodies) activity leads to changes in the metabolism of non-essential amino acids.

  3. In mice with conditional knockout of Sdhd, we found that the Cdkn1a (show CDKN1A Antibodies) gene was up-regulated in kidney and adrenal. This gene encodes the cyclin-dependent kinase (show CDK1 Antibodies) inhibitor p21(WAF1/Cip1 (show CDKN1A Antibodies)), a factor implicated in cell cycle, senescence, and cancer.

  4. complete loss of SdhD is not sufficient to induce tumorigenesis in mice

  5. SDHD is required for the formation of a stable mitochondrial complex II, and it is selectively important for hypoxic pulmonary vasoconstriction of intra-acinar vessels.

  6. Knockout of Sdhd in the mouse does not result in a disease phenotype; H19 (show NCKAP1 Antibodies) may not be an initiator of PGL (show PGLS Antibodies)/PC tumorigenesis

  7. Mitochondrial Sdhd is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to cell hypoxia.

Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) Antigen Profile

Protein Summary

This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with SDHD

  • succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD) antibody
  • succinate dehydrogenase complex, subunit D, integral membrane protein (Sdhd) antibody
  • 3110001M13Rik antibody
  • AVLL5809 antibody
  • C78570 antibody
  • CBT1 antibody
  • CII-4 antibody
  • CII4 antibody
  • CWS3 antibody
  • CybS antibody
  • PGL antibody
  • PGL1 antibody
  • PRO19626 antibody
  • QPs3 antibody
  • SDH4 antibody

Protein level used designations for SDHD

succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial , succinate-ubiquinone oxidoreductase cytochrome b small subunit , succinate-ubiquinone reductase membrane anchor subunit , Succinate dehydrogenase complex subunit D , Succinate-ubiquinone oxidoreductase cytochrome b small subunit , Succinate-ubiquinone reductase membrane anchor subunit , succinate dehydrogenase complex subunit D , CII-4 , QPs3 , cybS

GENE ID SPECIES
6392 Homo sapiens
479438 Canis lupus familiaris
100048954 Sus scrofa
281481 Bos taurus
66925 Mus musculus
363061 Rattus norvegicus
419793 Gallus gallus
101111485 Ovis aries
100172275 Pongo abelii
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