Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Proteins (SDHD)

SDHD encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. Additionally we are shipping Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Antibodies (41) and Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SDHD 6392 O14521
SDHD 66925 Q9CXV1
Rat SDHD SDHD 363061 Q6PCT8
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Top Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Proteins at antibodies-online.com

Showing 6 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_Escherichia coli (E. coli) Salmonella heidelberg His-SUMO Tag   50 μg Log in to see 11 Days
$341.00
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Yeast Salmonella heidelberg His tag   50 μg Log in to see 8 to 11 Days
$341.00
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HOST_Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$688.00
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SDHD Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
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More Proteins for Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) Interaction Partners

Human Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) interaction partners

  1. SDH-deficient gastrointestinal stromal tumors (GISTs) account for approximately 8% of gastric GISTs and are associated with a high rate of distant metastasis, regardless of conventional risk category.

  2. For classification, tumors were characterized by SDHA (show SDHA Proteins), B, C, or D (SDHX) mutations and other genetic and epigenetic alterations, including presence of mutations in germline

  3. Heterozygous germline deletions of up to 104 kb in size were identified in SDHB (show SDHB Proteins), SDHC (show SDHC Proteins), SDHD and flanking genes in 20 paraganglioma-pheochromocytoma patients. The exact breakpoint could be determined in 16 paraganglioma-pheochromocytoma patients of which 15 were novel deletions

  4. our study reveals a novel mechanism of crosstalk amongst SDHD, PTEN and autophagy pathways and their potential roles in thyroid carcinogenesis

  5. According to international guidelines, SDHB (show SDHB Proteins), SDHC (show SDHC Proteins), and SDHD genetic testing were performed in this patient, but not SDHA (show SDHA Proteins), which would have been prescribed only after surgery, in case of SDHA (show SDHA Proteins) negative immunohistochemistry

  6. Mortality rates and survival in a Dutch cohort of SDHD variant carriers does not differ from that of the general Dutch population.

  7. Melanomas harbor recurrent SDHD promoter mutations, which occur primarily as C>T alterations in UV-exposed melanomas.

  8. Loss of SDH activity leads to changes in the metabolism of non-essential amino acids.

  9. significant association with overall survival were confirmed for SDHC (show SDHC Proteins) gene, SDHD gene and FH gene ... SDHC (show SDHC Proteins) gene and FH gene were the primary factors contributing to the different overall survival time of colorectal carcinoma

  10. 15 YEARS OF PARAGANGLIOMA: Genetics and mechanism of pheochromocytoma-paraganglioma syndromes characterized by germline SDHB (show SDHB Proteins) and SDHD mutations

Pig (Porcine) Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) interaction partners

  1. The expression and sequencing of SDHD and single nucleotide polymorphisms of the gene are reported.

Mouse (Murine) Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) interaction partners

  1. Loss of SDH (show SDS Proteins) activity leads to changes in the metabolism of non-essential amino acids.

  2. In mice with conditional knockout of Sdhd, we found that the Cdkn1a (show CDKN1A Proteins) gene was up-regulated in kidney and adrenal. This gene encodes the cyclin-dependent kinase (show CDK1 Proteins) inhibitor p21(WAF1/Cip1 (show CDKN1A Proteins)), a factor implicated in cell cycle, senescence, and cancer.

  3. complete loss of SdhD is not sufficient to induce tumorigenesis in mice

  4. SDHD is required for the formation of a stable mitochondrial complex II, and it is selectively important for hypoxic pulmonary vasoconstriction of intra-acinar vessels.

  5. Knockout of Sdhd in the mouse does not result in a disease phenotype; H19 (show NCKAP1 Proteins) may not be an initiator of PGL (show PGLS Proteins)/PC tumorigenesis

  6. Mitochondrial Sdhd is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to cell hypoxia.

Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD) Protein Profile

Protein Summary

This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with SDHD

  • succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD)
  • succinate dehydrogenase complex, subunit D, integral membrane protein (Sdhd)
  • 3110001M13Rik protein
  • AVLL5809 protein
  • C78570 protein
  • CBT1 protein
  • CII-4 protein
  • CII4 protein
  • CWS3 protein
  • CybS protein
  • PGL protein
  • PGL1 protein
  • PRO19626 protein
  • QPs3 protein
  • SDH4 protein

Protein level used designations for SDHD

succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial , succinate-ubiquinone oxidoreductase cytochrome b small subunit , succinate-ubiquinone reductase membrane anchor subunit , Succinate dehydrogenase complex subunit D , Succinate-ubiquinone oxidoreductase cytochrome b small subunit , Succinate-ubiquinone reductase membrane anchor subunit , succinate dehydrogenase complex subunit D , CII-4 , QPs3 , cybS

GENE ID SPECIES
6392 Homo sapiens
479438 Canis lupus familiaris
100048954 Sus scrofa
281481 Bos taurus
66925 Mus musculus
363061 Rattus norvegicus
419793 Gallus gallus
101111485 Ovis aries
100172275 Pongo abelii
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