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Succinate-CoA Ligase, alpha Subunit Proteins (SUCLG1)

SUCLG1 encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. Additionally we are shipping Succinate-CoA Ligase, alpha Subunit Antibodies (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SUCLG1 8802 P53597
SUCLG1 114597 P13086
SUCLG1 56451 Q9WUM5
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Top Succinate-CoA Ligase, alpha Subunit Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,816.00
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Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,816.00
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Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,816.00
Details

SUCLG1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for Succinate-CoA Ligase, alpha Subunit (SUCLG1) Interaction Partners

Human Succinate-CoA Ligase, alpha Subunit (SUCLG1) interaction partners

  1. First Chinese report of succinyl-CoA ligase (show SUCLG2 Proteins) deficiency caused by novel SUCLG1 mutations; five novel pathogenic mutations in SUCLG1 were identified

  2. 3 novel mutations have been identified in patients with the mitochondrial DNA depletion syndrome (c.1048G>A and c.1049G>T in SUCLA2 (show SUCLA2 Proteins) and c.531+4A>T in SUCLG1).

  3. Our results suggest that SUCLG1 mutations that lead to complete absence of SUCLG1 protein are responsible for a very severe disorder with antenatal manifestations, whereas a SUCLA2 (show SUCLA2 Proteins)-like phenotype is found in patients with residual SUCLG1 protein.

  4. This report enlarges the phenotypic spectrum of SUCLG1 mutations and confirms that a characteristic metabolic profile (presence of MMA (show MMD Proteins) and C4-DC carnitine in urines) and basal ganglia MRI (show C7ORF49 Proteins) lesions are the hallmarks of SCS (show TWIST1 Proteins) defects.

  5. A novel mutation in the SUCLG1 gene was found in two newborns having lethal lactic acidosis, multi-organ failure and congenital malformations including interrupted aortic arch.

Pig (Porcine) Succinate-CoA Ligase, alpha Subunit (SUCLG1) interaction partners

  1. Structure of GTP-specific succinyl-CoA synthetase subunits in complex with CoA has been resolved.

  2. succinyl-CoA (show OXCT1 Proteins) synthetase is able to protect GTP (show AK3 Proteins) from hydrolysis when the active-site histidine residue is not in position to be phosphorylated

Mouse (Murine) Succinate-CoA Ligase, alpha Subunit (SUCLG1) interaction partners

  1. ADP and GDP succinyl-CoA (show OXCT1 Proteins) synthetases have different expression patterns and specificity

Succinate-CoA Ligase, alpha Subunit (SUCLG1) Protein Profile

Protein Summary

This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion.

Gene names and symbols associated with SUCLG1

  • succinate-CoA ligase, alpha subunit (SUCLG1)
  • succinate-CoA ligase, alpha subunit (suclg1)
  • succinate-CoA ligase, alpha subunit (Suclg1)
  • succinate-CoA ligase, GDP-forming, alpha subunit (suclg1)
  • succinate-CoA ligase, GDP-forming, alpha subunit (Suclg1)
  • 1500000I01Rik protein
  • GALPHA protein
  • MTDPS9 protein
  • SCS protein
  • Sucla1 protein
  • zgc:92738 protein
  • zgc:103729 protein

Protein level used designations for SUCLG1

succinate-CoA ligase, GDP-forming, alpha subunit , succinate-CoA ligase, GDP-forming alpha subunit , SCS-alpha , succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial , succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial , succinyl-CoA synthetase subunit alpha , succinyl-CoA synthetase alpha subunit , SUCLGa

GENE ID SPECIES
470417 Pan troglodytes
475775 Canis lupus familiaris
494796 Xenopus laevis
594977 Xenopus (Silurana) tropicalis
8802 Homo sapiens
399539 Sus scrofa
114597 Rattus norvegicus
509983 Bos taurus
436850 Danio rerio
56451 Mus musculus
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