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Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2) ELISA Kits

Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. Additionally we are shipping SUCLA2 Antibodies (17) and SUCLA2 Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse SUCLA2 SUCLA2 20916 Q9Z2I9
Anti-Human SUCLA2 SUCLA2 8803 Q9P2R7
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More ELISA Kits for SUCLA2 Interaction Partners

Mouse (Murine) Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2) interaction partners

  1. Sucla2(SAbetageo) homozygotes exhibited recessive lethality, with most mutants dying late in gestation (e18.5). Mutant placenta and embryonic (e17.5) brain, heart and muscle showed varying degrees of mitochondrial DNA depletion.

  2. ADP and GDP succinyl-CoA (show OXCT1 ELISA Kits) synthetases have different expression patterns and specificity

Human Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2) interaction partners

  1. Sucla2 is related to the developmental stages of mouse spermatogenesis. Knockdown of Sucla2 decreases the viability of mouse spermatocytes by inducing apoptosis via decreased mitochondrial function of the cells.

  2. Long survival, to age 20 years or older, was reported in 12% of SUCLA2 and in 10% of SUCLG1 (show SUCLG1 ELISA Kits) patients.

  3. XDH (show XDH ELISA Kits) and SUCLA2 genes associated with thiopurine-induced leukopenia can act in a complex interactive manner in patients with Crohn's disease.

  4. The absence of SUCLA2 and SUCLG2 (show SUCLG2 ELISA Kits) in human glia is in compliance with the presence of alternative pathways occurring in these cells, namely the GABA shunt and ketone body metabolism

  5. SUCLA2 mutations should be analyzed in patients with slowly progressive encephalomyopathy, even in the absence of methylmalonic aciduria or mitochondrial DNA depletion.

  6. This study demonstrated that SUCLA2 is expressed exclusively in neurons in the human cerebral cortex.

  7. Identification of a novel mutation in SUCLA2 in two cousins affected with encephalomyopathy, is reported.

  8. A novel homozygous mutation in SUCLA2 gene has been associated with severe mitochondrial encephalomyopathies in two Italian siblings.

  9. 3 novel mutations have been identified in patients with the mitochondrial DNA depletion syndrome (c.1048G>A and c.1049G>T in SUCLA2 and c.531+4A>T in SUCLG1 (show SUCLG1 ELISA Kits)).

  10. X-linked sideroblastic anemia due to carboxyl-terminal ALAS2 (show ALAS2 ELISA Kits) mutations that cause loss of binding to the beta-subunit (show POLG ELISA Kits) of succinyl-CoA (show OXCT1 ELISA Kits) synthetase (SUCLA2).

SUCLA2 Antigen Profile

Antigen Summary

Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6.

Gene names and symbols associated with SUCLA2

  • succinate-Coenzyme A ligase, ADP-forming, beta subunit (Sucla2) antibody
  • succinate-CoA ligase, ADP-forming, beta subunit (SUCLA2) antibody
  • 4930547K18Rik antibody
  • A-BETA antibody
  • MTDPS5 antibody
  • SCS antibody
  • SCS-betaA antibody

Protein level used designations for SUCLA2

ATP-specific succinyl-CoA synthetase subunit beta , SCS-betaA , succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial , succinyl-CoA synthetase beta-A chain , ATP-specific succinyl-CoA synthetase, beta subunit , mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta , renal carcinoma antigen NY-REN-39 , ATP-specific succinyl-CoA synthetase beta , Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial

20916 Mus musculus
8803 Homo sapiens
511090 Bos taurus
485448 Canis lupus familiaris
399540 Sus scrofa
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