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SI encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. Additionally we are shipping Sucrase-Isomaltase (Alpha-Glucosidase) Kits (7) and Sucrase-Isomaltase (Alpha-Glucosidase) Antibodies (6) and many more products for this protein.
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Core2 O-glycan structure is essential for expression of SI and DDP (show TIMM8A Proteins)-IV during intestinal cell differentiation.
These suggest that induction of SI gene by the diet rich in carbohydrate is associated with acetylation of histone H3 (show HIST3H3 Proteins) and H4 as well as binding of HNF-1 (show HNF1A Proteins) and Cdx-2 (show CDX2 Proteins) on SI gene.
These results suggest that sucrase-isomaltase transcription might be unchanged or lower in maturity-onset diabetes of the young (MODY (show HNF4A Proteins)) type 3, but greater in MODY5 (show HNF1B Proteins).
phenylalanine cluster is required for shielding a folding determinant in the extracellular domain of SI; substitution of a Q by a P at residue 1098 of sucrase disrupts this determinant and elicits retention of SI(Q1098P) in ER and cis (show CISH Proteins)-Golgi
hepatocyte nuclear factor (HNF)-1alpha (show HNF1A Proteins) and HNF-1beta (show HNF1B Proteins) would contribute to constitutive expression of the SI gene in the differentiated state in Caco-2 cells
glucose regulation of sucrase-isomaltase gene expression was attenuated in HNF-1alphaT539fsdelC cells, but was well maintained in empty vector & HNF-1betaR177X cells.Results suggest that HNF-1alpha (show HNF1A Proteins) participates in glucose regulation of SI gene expression.
This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.
, sucrase isomaltase, structural
, oligosaccharide alpha-1,6-glucosidase