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Sulfiredoxin 1 Proteins (SRX1)

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Additionally we are shipping Sulfiredoxin 1 Antibodies (31) and Sulfiredoxin 1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SRX1 140809 Q9BYN0
Rat SRX1 SRX1 296271  
SRX1 76650 Q9D975
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Top Sulfiredoxin 1 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

SRX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Sulfiredoxin 1 (SRX1) Interaction Partners

Human Sulfiredoxin 1 (SRX1) interaction partners

  1. Study shows that Srx plays a critical oncogenic role to promote cell invasion and metastasis, which is at least partially due to its stimulation of the MAPK (show MAPK1 Proteins) pathway through EGFR (show EGFR Proteins) deacetylation.

  2. This review will summarize the molecular basis of differences in the affinity of Srx for individual Prx (show PRDX6 Proteins) and the role of individual component of the Srx-Prx (show PRDX6 Proteins) system in tumor progression and metastasis.

  3. Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-beta (show PPARD Proteins).

  4. NRF2 (show GABPA Proteins) and SRXN1 genetic polymorphisms are associated with breast cancer risk and survival

  5. SRX forms a complex with S100A4 (show S100A4 Proteins) (and has stronger affinity for S-glutathionylated S100A4 (show S100A4 Proteins)), regulates its activity, and mediates redox regulation of the interaction of S100A4 (show S100A4 Proteins) with nonmuscle myosin heavy chain II-A (show MYH9 Proteins).

  6. Srx functions as a novel component to maintain the balance between H2O2 production and elimination

  7. Real-time PCR validated that up-regulation of sulphiredoxin 1 homolog (SRXN1), hemeoxygenase 1 (HMOX1), and breast carcinoma amplified sequence 3 (BCAS3) were consistently modulated.

  8. Srx-Prx IV (show PRDX4 Proteins) axis is critical for lung cancer maintenance and metastasis, suggesting that targeting the Srx-Prx IV (show PRDX4 Proteins) axis may provide unique effective strategies for cancer prevention and treatment.

  9. sulfiredoxin 1 is associatd with the pathogenesis of human pulmonary fibrosis.

  10. Studies present the 2.1 A crystal structure of human Srx in complex with PrxI (show PRDX1 Proteins), ATP, and Mg(2 (show MUC7 Proteins)+).

Mouse (Murine) Sulfiredoxin 1 (SRX1) interaction partners

  1. sulfiredoxin is degraded by Lon (show LONP1 Proteins) in a manner dependent on PrxIII (show PRDX3 Proteins) hyperoxidation state.

  2. Srx is one of the critical components that contribute to mouse skin tumorigenesis in vivo.

  3. data provide in vivo evidence that loss of Srx renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis, suggesting that Srx has a critical oncogenic role in cancer development

  4. The concerted action of PrxIII (show PRDX3 Proteins) and Srx is important for protection against pyrazole-induced oxidative stress arising from the convergent induction of CYP2E1 (show CYP2E1 Proteins)-derived and ER stress-derived ROS (show ROS1 Proteins) in mitochondria.

  5. Srx functions as a novel component to maintain the balance between H2O2 production and elimination

  6. NO-mediated Srx up-regulation is mediated by the transcription factor nuclear factor erythroid 2-related factor (Nrf2 (show NFE2L2 Proteins)) and the NO/Srx pathway inhibits generation of reactive oxygen species.

  7. LPS (show TLR4 Proteins)-mediated Srx induction is dependent on both AP-1 (show JUN Proteins) and Nrf2 (show NFE2L2 Proteins), which is regulated by Nox2 (show CYBB Proteins)-derived reactive oxygen species.

  8. Synaptic activity upregulated the thioredoxin (show TXN Proteins)-peroxiredoxin reactivating gene sulfiredoxin.

Sulfiredoxin 1 (SRX1) Protein Profile

Protein Summary

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.

Gene names and symbols associated with Sulfiredoxin 1 Proteins (SRX1)

  • sulfiredoxin 1 (SRXN1)
  • sulfiredoxin 1 homolog (S. cerevisiae) (srxn1)
  • sulfiredoxin 1 (Srxn1)
  • sulfiredoxin 1 homolog (S. cerevisiae) (Srxn1)
  • 1700127B04Rik protein
  • Ab2-390 protein
  • AI854065 protein
  • AW488194 protein
  • C20orf139 protein
  • Npn3 protein
  • Srx protein
  • Srx1 protein
  • TX01 protein

Protein level used designations for Sulfiredoxin 1 Proteins (SRX1)

sulfiredoxin 1 , sulfiredoxin 1 homolog , sulfiredoxin-1 , sulfiredoxin-1-like , sulfiredoxin 1 homolog (S. cerevisiae) , neoplastic progression 3 , neoplastic progression protein 3

GENE ID SPECIES
469853 Pan troglodytes
714997 Macaca mulatta
100331561 Danio rerio
140809 Homo sapiens
100858692 Gallus gallus
531606 Bos taurus
296271 Rattus norvegicus
76650 Mus musculus
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