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May be involved in pre-mRNA splicing. Additionally we are shipping and many more products for this protein.
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Human Polyclonal SKIV2L2 Primary Antibody for ICC, IF - ABIN151119
Nag, Steitz: Tri-snRNP-associated proteins interact with subunits of the TRAMP and nuclear exosome complexes, linking RNA decay and pre-mRNA splicing. in RNA biology 2012
Show all 2 Pubmed References
The competition between hMTR4 and ALYREF (show THOC4 Antibodies) determines exosome recruitment and functions in creating balanced nuclear RNA pools for degradation and export.
The described is the mRNA degradation poly(A) tail exosome targeting (PAXT) connection, which comprises the ZFC3H1 Zn-knuckle protein as a central link between MTR4 and the nuclear poly(A)-binding protein PABPN1 (show PABPN1 Antibodies).
We analyzed the interactions of the human TRAMP (show DPT Antibodies)-like proteins, PAPD5 (show PAPD5 Antibodies), ZCCHC7, and MTR4, with the nuclear exosome. PAPD5 (show PAPD5 Antibodies) and ZCCHC7 exhibited mutual interactions in presence of the exosome catalytic subunit RRP6 (show EXOSC10 Antibodies), whereas MTR4 was dispensable for their assembly
results suggest that WDR74 is a novel regulatory protein of the MTR4-exsosome complex whose interaction is regulated by NVL2 (show HPCAL4 Antibodies) and is involved in ribosome biogenesis
Nuclear VCP (show NVL Antibodies)/p97 (show vcp Antibodies)-like protein 2 might regulate the association/dissociation reaction of DOB1 with pre-ribosomal particles by acting as a molecular chaperone (show HSP90AA1 Antibodies).
Skiv2l2 knockdown cells accumulated replication-dependent histone mRNAs, among other RNAs, that could impede mitotic progression and indirectly trigger differentiation.
Study reports that the noncoding RNA processing activity of RNA exosome, a 3'-5' RNA exonuclease (show EXO1 Antibodies), controls sense and antisense strand DNA mutagenesis, and prevents an increased asymmetric mutagenesis burden using a mechanism that relies on the unexpected DNA/RNA hybrid unwinding activities of the Mtr4 and senataxin (show SETX Antibodies) RNA helicases.
Results identify novel role for Mtr4 in targeting the 5' leader sequences of microRNAs for degradation.
SKIV2L2 is an RNA-binding protein localized to the nucleus in the round spermatids of mice
May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA.
superkiller viralicidic activity 2-like 2
, superkiller viralicidic activity 2-like 2 (S. cerevisiae)
, Superkiller viralicidic activity 2-like 2
, superkiller viralicidic activity 2-like 2-like
, ATP-dependent helicase SKIV2L2
, functional spliceosome-associated protein 118