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Superoxide Dismutase 1, Soluble Proteins (SOD1)

The protein encoded by SOD1 binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. Additionally we are shipping Superoxide Dismutase 1, Soluble Antibodies (513) and Superoxide Dismutase 1, Soluble Kits (72) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse SOD1 SOD1 16005 P70389
Rat SOD1 SOD1 79438 P35859
Human SOD1 SOD1 6647 P00441
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Top Superoxide Dismutase 1, Soluble Proteins at antibodies-online.com

Showing 10 out of 110 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 7 to 9 Days
$364.64
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human GST tag Superoxide Dismutase 1, Soluble (SOD1) (AA 2-154), (full length) protein (GST tag) 1 mg Log in to see 56 to 66 Days
$1,842.50
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 11 Days
$300.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Human His tag Human SOD1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%. 100 μg Log in to see 2 to 3 Days
$217.80
Details

SOD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Rat (Rattus) ,

Human , , ,
,

Top referenced Superoxide Dismutase 1, Soluble Proteins

  1. Human SOD1 Protein expressed in Escherichia coli (E. coli) - ABIN2004728 : Kostrzewa, Damian, Müller: Superoxide dismutase 1: identification of a novel mutation in a case of familial amyotrophic lateral sclerosis. in Human genetics 1996 (PubMed)
    Show all 4 references for ABIN2004728

  2. Human SOD1 Protein expressed in Escherichia coli (E. coli) - ABIN667079 : Banci, Bertini, Boca, Girotto, Martinelli, Valentine, Vieru: SOD1 and amyotrophic lateral sclerosis: mutations and oligomerization. in PLoS ONE 2008 (PubMed)
    Show all 3 references for ABIN667079

More Proteins for Superoxide Dismutase 1, Soluble (SOD1) Interaction Partners

Silk Worm Superoxide Dismutase 1, Soluble (SOD1) interaction partners

Mouse (Murine) Superoxide Dismutase 1, Soluble (SOD1) interaction partners

  1. the damage and satellite cell state of the gastrocnemius muscle in SOD1 knockout mice, was investigated.

  2. Events occurring locally in the skeletal muscle of SOD1 mutant mice contribute to the impairment of CaV1.1 function in ALS muscle independently of innervation status.

  3. G85R-SOD1:YFP inclusion pathology quickly spreads to discrete neurons in the brainstem and midbrain that are synaptically connected to spinal neurons

  4. SOD1 aggregates interact with the cell surface triggering activation of Rac1 and subsequent membrane ruffling permitting aggregate uptake via stimulated macropinocytosis

  5. provides evidence for a novel interaction of alpha-synuclein and SOD1 that might be relevant for neurodegenerative diseases

  6. age-related increases were mitigated by caloric restriction but not super oxide dismutase 1 overexpression

  7. postmitotic expression SOD1G93A mutant gene promotes a FAPS phenotype in C2C12 cells, by upregulating HDAC4 (show HDAC5 Proteins) protein and preventing the BAF60C (show SMARCD3 Proteins)-SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complex myogenic commitment

  8. The oxidative stress of diabetes mellitus impairs Wnt (show WNT2 Proteins) signaling and causes cardiac outlet defects that are rescued by SOD1 overexpression

  9. This study demonistrated that proprioceptive nerve endings in muscles revealed early and significant alterations at Ia/II proprioceptive nerve endings in muscle spindles and occur alongside those at alpha-motor axons in SOD1(G93A) mice.

  10. Mutant SOD1 Increases APP Expression and Phosphorylation in Cellular and Animal Models of ALS

Caenorhabditis elegans (C. elegans) Superoxide Dismutase 1, Soluble (SOD1) interaction partners

  1. the C. elegans intracellular CuZn-SODs (wSOD-1 and wSOD-5) are not dependent on the copper chaperone CCS (show CCS Proteins) for activation

  2. although several long-lived mutants of Caenorhabditis elegans have increased SOD levels, this phenomenon does not correlate with life span or growth rate.

  3. SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold.

  4. the ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans

  5. this suggests that the activity of SOD-1, which so far has been thought to act mainly in cytoplasm, helps to control the detoxification of *O2- also in the mitochondria.

Fruit Fly (Drosophila melanogaster) Superoxide Dismutase 1, Soluble (SOD1) interaction partners

  1. The functional SOD1 and SOD2 (show SOD2 Proteins) genes knockout and their overexpression in neurons and glial tissue increase the sensitivity of Drosophila melanogaster to oxidative stress conditions.

  2. Expression of zinc-deficient human superoxide dismutase (show SOD2 Proteins) in Drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction.

  3. curcumin increases mean lifespan of Drosophila via regulating gene expression of the key enzyme SOD and reducing accumulation of MDA and lipid peroxidation.

  4. The activity of carbohydrate metabolizing enzymes, lipid and triglyceride concentration, and steady state NADPH:NADP(+) in SOD1-null and control transgenic rescue flies, was analysed.

  5. Overexpression of Cu,ZnSOD and MnSOD (show SOD2 Proteins) in transgenic Drosophila.

  6. Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity.

  7. SOD1 and SOD2 (show SOD2 Proteins) provide independent protection to compartment-specific protein iron-sulfur clusters against attack by superoxide generated under oxidative stress

  8. A 1140 base pair region, composed of the single sod1 intron along with exon 2, was found to be essential for permitting spatial and temporal expression patterns that approximate normal endogenous expression.

  9. Cu/Zn superoxide dismutase has a role in preventing spontaneous DNA damage

  10. Instability of superoxide dismutase 1 of Drosophila in mutants deficient for its cognate copper chaperone

Human Superoxide Dismutase 1, Soluble (SOD1) interaction partners

  1. Data show that antioxidant enzymes SOD2 (show SOD2 Proteins) and GPX1 (show GPX1 Proteins) expression and GPX1 (show GPX1 Proteins) and SOD1 activity were significantly higher in patients at diagnosis of bladder cancer (BC) in comparison to controls.

  2. Study showed that endothelial cells from human umbilical vein have a reduced activity and gene expression of the "classic" antioxidant enzymes (Cu,Zn-superoxide dismutase, catalase (show CAT Proteins), and Se-containing glutathione peroxidase (show GPX1 Proteins)). At the same time, a high expression level of peroxiredoxin genes was identified in the same endothelial cells

  3. a structural model for protofibril capping of SOD1 filaments by alphaB-crystallin (show CRYAB Proteins)

  4. The effects of oleuropein (OL) on hydrogen peroxide-induced oxidative stress in L02 cells showed that SOD1, GPx1 (show GPX1 Proteins), and catalase (show CAT Proteins) levels were all increased, and suggested that OL is a potent antioxidant and may be therapeutically useful in liver disease prevention.

  5. The toxicity of the misfolded wild-type SOD1 is involved in the pathogenesis of sporadic Amyotrophic lateral sclerosis. [review]

  6. The purpose of the study was to evaluate the plasma level of superoxide dismutase (SOD), catalase (show CAT Proteins) (CAT), and glutathione peroxidase (GPX (show GPX1 Proteins)) and the association between polymorphic variants in genes encoding for GPx1 (show GPX1 Proteins), SOD, CAT and the risk of distal symmetric polyneuropathy in type 2 diabetes mellitus patients.

  7. This study identified the L84F mutation in SOD1 in a amyotrophic lateral sclerosis family from North India

  8. Study found expression of several mutated forms of SOD1 in the NSC-34 motor neuronal cells induces the formation of cytosolic and sometimes nuclear aggregates containing the SUMO-1 (show SUMO1 Proteins) protein and showed that the formation of these aggregates can be modulated by action on the K75 (show KRT75 Proteins) SUMOylation site

  9. the effects of oxidative modification on SOD1 monomer and homodimer stability

  10. The expression of hSOD1 in the liver of Sod1(-/-) mice significantly improved the lifespan of Sod1(-/-) mice; however, the lifespan of the Sod1(-/-)/hSOD1(alb (show ALB Proteins)) mice was still significantly shorter than wild type mice.

Pig (Porcine) Superoxide Dismutase 1, Soluble (SOD1) interaction partners

  1. CuZnSOD mRNA is a broad-spectrum expression gene, which was detected in brain, heart, spleen, liver, kidney, lung, large intestine, small intestine, spinal cord, muscle, backfat, and stomach

Cow (Bovine) Superoxide Dismutase 1, Soluble (SOD1) interaction partners

  1. SOD catalyzes reversal of autoxidation manifesting as its inhibition. SOD saves catechols from autoxidation and extends their bioavailability

  2. antioxidative enzymatic mechanisms in bovine placental tissues are represented by superoxide dismutase 1 and glutathione peroxidase (show GPX1 Proteins), which show the changes in their expression during improper placental release

  3. Results sugget thet Copper/Zinc superoxide dismutase (SOD1) may play a role in controlling intraluteal prostaglandin F2alph and reactive oxygen species action during functional and structural luteolysis.

  4. ALOX5AP (show ALOX5AP Proteins), CPNE3 (show CPNE3 Proteins), IL1R2 (show IL1R2 Proteins), IL6 (show IL6 Proteins), TLR2, TLR4 (show TLR4 Proteins), and THY1 (show THY1 Proteins) were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.

  5. Acute elevation of SOD may represent a response of luteal endothelial cells to protect themselves against oxidative stress induced (show SQSTM1 Proteins) by PGF (show PGF Proteins) during functional luteolysis.

  6. At room temperature (25.0 degrees C) and higher, the addition of high concentrations of polymer is found to significantly enhance the affinity of SOD for catalase (show CAT Proteins).

  7. Capillary electrophoresis and mass spectrometry to study the different structures of bovine SOD-1. In both cases, an average molecular mass corresponding to the apo (show C9orf3 Proteins)-monomer SOD-1 was calculated.

  8. flexibility of the metal sites involved in present a single-crystal X-ray diffraction study of Cu,Zn superoxide dismutase in space group P212121 at 0.57 GPa (show GYPA Proteins). The crystal structure (hpSOD) was determined and refined at 2 A degrees resolution.

  9. expression profile in follicles: oocytes (SOD1 throughout ooplasm & nucleoplasm); cumulus cells (no SOD1 detected); granulosa cells (expressed SOD1); follicular fluid (small follicles show increased amounts of SOD1 in comparison with large follicles)

  10. Bovine erythrocyte Cu,Zn-superoxide dismutase (BESOD) is a dimeric enzyme composed of identical subunits associated through unusually strong non-covalent interactions.

Rabbit Superoxide Dismutase 1, Soluble (SOD1) interaction partners

  1. amyloid and oxidative stress-related disease proteins like SOD 1 is increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.

Zebrafish Superoxide Dismutase 1, Soluble (SOD1) interaction partners

  1. The earliest event in the pathophysiology of amyotrohic lateral sclerosis in the mutant sod1 zebrafish model involves neuronal stress in inhibitory interneurons, resulting from mutant Sod1 expression.

  2. A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Proteins), sp1 (show SP1 Proteins) and sod1 in zebrafish.

  3. depresses cathepsin L (show CTSL1 Proteins) activity stimulated by free radicals and prevents otic complications associated with bone erosion

  4. Copper/zinc superoxide dismutase was cloned from the zebrafish ( Danio rerio). Evidence is presented that SOD protects against paraquat toxicity in fish.

  5. Glia maturation factor-null cells ahow a concurrent decrease in CuZnSOD astrocytes.

Superoxide Dismutase 1, Soluble (SOD1) Protein Profile

Protein Summary

The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.

Gene names and symbols associated with SOD1

  • superoxide dismutase 1, soluble (sod1)
  • Superoxide dismutase [Cu-Zn] (SOD1)
  • Cu/Zn superoxide dismutase (A245R)
  • Cu/Zn superoxide dismutase (SOD2.2)
  • Cu/Zn superoxide dismutase (sod1)
  • superoxide dismutase 1, soluble (SOD1)
  • Cu/Zn superoxide dismutase (SOD)
  • insulin-like growth factor binding protein, acid labile subunit (Igfals)
  • Protein SOD-1 (sod-1)
  • Superoxide dismutase (Sod)
  • superoxide dismutase [Cu-Zn]-like (LOC101451855)
  • superoxide dismutase 1, soluble (Sod1)
  • superoxide dismutase 1, soluble (sod1-b)
  • Albs protein
  • als protein
  • als1 protein
  • B430204E11Rik protein
  • CG11793 protein
  • cSod protein
  • Cu protein
  • Cu-Zn SOD protein
  • CU/ZN-SOD protein
  • Cu/ZnSOD protein
  • Cu/Zn sod protein
  • Cu/Zn superoxide dismutase protein
  • CuSOD protein
  • cuzn protein
  • CuZn-SOD protein
  • CuZn-SOD1 protein
  • CuZnSOD protein
  • CuZn SOD protein
  • Cu[2+]/Zn[2+]SOD protein
  • DKFZP469M1833 protein
  • Dmel\\CG11793 protein
  • dSOD1 protein
  • G protein
  • homodimer protein
  • hSod1 protein
  • Ipo-1 protein
  • Ipo1 protein
  • ipoa protein
  • l(3)68Af' protein
  • l(3)108 protein
  • l(3)G protein
  • LOC692639 protein
  • mKIAA4111 protein
  • Mn SOD protein
  • sod protein
  • Sod-1 protein
  • Sod1 protein
  • sod1-a protein
  • SOD1L1 protein
  • SODC protein
  • To protein
  • To-1 protein
  • XSODB protein
  • Zn-SOD protein
  • ZnSod protein
  • Zn Sod protein
  • ZSOD protein

Protein level used designations for SOD1

superoxide dismutase [Cu-Zn] , Cu/Zn superoxide dismutase , superoxide dismutase 1 soluble , superoxide dismutase , Cu/Zn SOD , insulin-like growth factor-binding protein complex acid labile subunit , insulin-like growth factor binding protein complex acid-labile subunit , insulin-like growth factor-binding protein complex acid labile chain , CG11793-PA , CG11793-PD , Cu, Zn superoxide dismutase , Cu-Zn superoxide dismutase , Cu/Zn-Superoxide dismutase , CuZn superoxide dismutase , CuZn-superoxide dismutase , CuZn-superoxide dismutase (SOD)1 , CuZnSOD , Cu[2+] Zn[2+] superoxide dismutase , Cu[2+]Zn[2+] superoxide dismutase , Mn superoxide dismutase , Sod-PA , Sod-PD , complementation group G , copper and zinc SOD , copper-zinc superoxide , copper-zinc superoxide dismutase , cytoplasmic Cu/ZnSOD , dismutase , super oxide dismutase , superoxidase dismutase , superoxide dismutase 1 , superoxide dismutatase , superoxide-dismutase , superoxido dismutase , tetrazolium oxidase , tetrazolium oxidase-1 , SOD, soluble , indophenoloxidase A , superoxide dismutase, cystolic , Cu(2+)-Zn2+ superoxide dismutase , superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) , Cu-Zn-superoxide dismutase , Cu,Zn-superoxide dismutase , sod(Cu/Zn) , Cu,Zn superoxide dismutase , superoxide dismutase [Cu-Zn] B

GENE ID SPECIES
100381040 Xenopus laevis
100499991 Glycine max
918416 Paramecium bursaria Chlorella virus 1
4836692 Scheffersomyces stipitis CBS 6054
100136454 Salmo salar
100172349 Pongo abelii
692639 Bombyx mori
16005 Mus musculus
79438 Rattus norvegicus
174141 Caenorhabditis elegans
39251 Drosophila melanogaster
101451855 Ceratitis capitata
6647 Homo sapiens
20655 Mus musculus
24786 Rattus norvegicus
100033855 Equus caballus
100135622 Cavia porcellus
403559 Canis lupus familiaris
397036 Sus scrofa
281495 Bos taurus
101115136 Ovis aries
100009313 Oryctolagus cuniculus
395938 Gallus gallus
100270717 Ovis aries
449637 Pan troglodytes
100861196 Capra hircus
574096 Macaca mulatta
30553 Danio rerio
394274 Xenopus laevis
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