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The protein encoded by ST13 is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. Additionally we are shipping Suppression of Tumorigenicity 13 (Colon Carcinoma) (Hsp70 Interacting Protein) Proteins (11) and many more products for this protein.
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Human Polyclonal ST13 Primary Antibody for EIA, WB - ABIN358737
Rajapandi, Greene, Eisenberg: The molecular chaperones Hsp90 and Hsc70 are both necessary and sufficient to activate hormone binding by glucocorticoid receptor. in The Journal of biological chemistry 2000
Show all 4 references for ABIN358737
Human Monoclonal ST13 Primary Antibody for EIA, IF - ABIN1109145
Zhou, Lucas, Chan, Issaq, Petricoin, Liotta, Veenstra, Conrads: An investigation into the human serum "interactome". in Electrophoresis 2004
Show all 2 references for ABIN1109145
Human Monoclonal ST13 Primary Antibody for EIA, IHC (p) - ABIN356232
Nelson, Prapapanich, Carrigan, Roberts, Riggs, Smith: The heat shock protein 70 cochaperone hip enhances functional maturation of glucocorticoid receptor. in Molecular endocrinology (Baltimore, Md.) 2004
Show all 2 references for ABIN356232
A novel susceptibility gene, ST13, coding for a cochaperone of the glucocorticoid receptor (show NR3C1 Antibodies), is associated with exacerbations in asthmatic children and young adults despite their ICS (show DNAI1 Antibodies) use.
St13 is a proliferation regulator that inhibits tumor growth in colorectal neoplasms and may affect cell migration.
Akt (show AKT1 Antibodies) phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase.
A single amino acid substitution (L211S) resulted in a loss of Hip function. This mutation also appears to disrupt the interaction of Hip with Hsp70 (show HSP70 Antibodies) in vitro
Hip has been identified as a novel substrate of GRK5 (show GRK5 Antibodies) in vitro and in cells, and phosphorylation of Hip by GRK5 (show GRK5 Antibodies) plays a role in modulating CXCR4 (show CXCR4 Antibodies) internalization
These results strongly indicate ST13 mediated by adenovirus triggers colorectal cell apoptosis via ASK1 (show MAP3K5 Antibodies)-JNK (show MAPK8 Antibodies) signaling cascade
S-nitrosoglutathione corrects DeltaF508 CFTR (show CFTR Antibodies) trafficking by inhibiting Hop (show STIP1 Antibodies) expression
The expression levels of ST13 cannot serve as a biomarker for early stages of PD.
Hip functions to promote the efficiency of glucocorticoid receptor (show NR3C1 Antibodies) maturation in cells
The expression of ST13 decreases in colorectal cancer tissue compared with that in adjacent normal tissue. ST13 is mostly expressed in colorectal epithelia and adenocarcinoma cells.
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene.
, Hsp70 interacting protein
, hsc70-interacting protein
, protein ST13 homolog
, suppression of tumorigenicity 13 (colon carcinoma) Hsp70-interacting protein
, Hsp70-interacting protein
, aging-associated protein 2
, heat shock 70kD protein binding protein
, progesterone receptor-associated p48 protein
, putative tumor suppressor ST13
, renal carcinoma antigen NY-REN-33
, suppression of tumorigenicity 13 protein