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Suppressor of Ty 4 Homolog 1 (S. Cerevisiae) Proteins (SUPT4H1)

SUPT4H1 encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. Additionally we are shipping Suppressor of Ty 4 Homolog 1 (S. Cerevisiae) Antibodies (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SUPT4H1 6827 P63272
Rat SUPT4H1 SUPT4H1 287608  
Mouse SUPT4H1 SUPT4H1 20922 P63271
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Top Suppressor of Ty 4 Homolog 1 (S. Cerevisiae) Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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Yeast Yeast His tag   1 mg Log in to see 56 to 66 Days
$2,181.67
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Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$2,190.83
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Yeast Candida albicans His tag   1 mg Log in to see 56 to 66 Days
$2,212.83
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Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,225.67
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Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,225.67
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Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,225.67
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Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,227.50
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Yeast REACT_Red bread mold His tag   1 mg Log in to see 56 to 66 Days
$2,236.67
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SUPT4H1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Suppressor of Ty 4 Homolog 1 (S. Cerevisiae) (SUPT4H1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Suppressor of Ty 4 Homolog 1 (S. Cerevisiae) (SUPT4H1) interaction partners

  1. analysis of the interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor (show RDBP Proteins)), and the Drosophila RNA polymerase II transcription elongation complex

Human Suppressor of Ty 4 Homolog 1 (S. Cerevisiae) (SUPT4H1) interaction partners

  1. Knockdown of SUPT4H1, the human Spt4 ortholog, similarly decreased production of sense and antisense RNA foci, as well as dipeptide repeat proteins, in patient cells.

  2. crystal structure of hSpt4 in complex with the dimerization region of hSpt5 (show SUPT5H Proteins)

  3. Upon induction of NF-kappaB (show NFKB1 Proteins), a subset of target genes is regulated differentially by either P-TEFb (show CCNT1 Proteins) or DSIF (show SUPT5H Proteins).[P-TEFb (show CCNT1 Proteins), DSIF (show SUPT5H Proteins)]

  4. These findings reveal a dynamic regulation of DSIF (show SUPT5H Proteins) involving either E-box or NF-kappaB (show NFKB1 Proteins) depending on the physiological circumstances.

  5. Spt4 was purified and characterized.

  6. These results suggest that one of the functions of Spt5 is to suppress senescence and apoptosis, and that this function is exerted through its association with Spt4 and Pol II.

  7. he Paf1 (show PEX2 Proteins) complex (Paf1C) and Tat-SF1, two factors implicated previously in elongation control, collaborate with DSIF (show SUPT5H Proteins) to facilitate efficient elongation

Mouse (Murine) Suppressor of Ty 4 Homolog 1 (S. Cerevisiae) (SUPT4H1) interaction partners

  1. reduction of SUPT4H in mouse brains is associated with decreased HTT (show HTT Proteins) protein aggregation, and in R6/2 mice, also with prolonged lifespan and delay of the motor impairment that normally develops in these animals.

  2. our findings indicate that Spt4 and Spt5 (show SUPT5H Proteins) have essential functions in the DNA repair phase of immunoglobulin class switch recombination.

  3. These findings indicate that Supt4h is differentially required for expression of the mutant Htt (show HTT Proteins) allele in mouse striatal neurons.

Suppressor of Ty 4 Homolog 1 (S. Cerevisiae) (SUPT4H1) Protein Profile

Protein Summary

This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with SUPT4H1

  • CG12372 gene product from transcript CG12372-RA (spt4)
  • Protein SPT-4 (spt-4)
  • suppressor of Ty 4 homolog 1 (supt4h1)
  • suppressor of Ty 4 homolog 1 (S. cerevisiae) (SUPT4H1)
  • suppressor of Ty 4 homolog 1 (S. cerevisiae) (Supt4h1)
  • suppressor of Ty 4A (Supt4a)
  • Zn-finger protein (SPT4)
  • 142904_at protein
  • AL022777 protein
  • CG12372 protein
  • dDSIF protein
  • Dmel\\CG12372 protein
  • DSIF protein
  • dspt4 protein
  • l(2)k05316 protein
  • Spt4 protein
  • SPT4H protein
  • Supt4h protein
  • Supt4h1 protein
  • Supt4h1a protein
  • Supt4h2 protein

Protein level used designations for SUPT4H1

CG12372-PA , DSIF , spt4-PA , DRB sensitivity-inducing factor small subunit , DSIF small subunit , transcription elongation factor SPT4 , DRB sensitivity-inducing factor 14 kDa subunit , DSIF p14 , small hSpt4 subunit , suppressor of Ty 4 homolog 1 , suppressor of Ty 4 homolog 2 , DRB sensitivity-inducing factor small subunit 1 , DSIF small subunit 1 , transcription elongation factor SPT4 1 , transcription elongation factor SPT4-A , hypothetical protein

GENE ID SPECIES
36387 Drosophila melanogaster
175172 Caenorhabditis elegans
734253 Xenopus laevis
6827 Homo sapiens
616425 Bos taurus
287608 Rattus norvegicus
100190855 Pongo abelii
20922 Mus musculus
3636395 Candida albicans SC5314
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