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SUPT4H1 encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. Additionally we are shipping Suppressor of Ty 4 Homolog 1 (S. Cerevisiae) Proteins (14) and many more products for this protein.
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analysis of the interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor (show RDBP Antibodies)), and the Drosophila RNA polymerase II transcription elongation complex
Chimeric transcript resulting from the fusion of RNF43 (show RNF43 Antibodies) and SUPT4H1 was found to occur frequently in primary colorectal carcinoma.
Knockdown of SUPT4H1, the human Spt4 ortholog, similarly decreased production of sense and antisense RNA foci, as well as dipeptide repeat proteins, in patient cells.
crystal structure of hSpt4 in complex with the dimerization region of hSpt5 (show SUPT5H Antibodies)
Upon induction of NF-kappaB (show NFKB1 Antibodies), a subset of target genes is regulated differentially by either P-TEFb (show CCNT1 Antibodies) or DSIF (show SUPT5H Antibodies).[P-TEFb (show CCNT1 Antibodies), DSIF (show SUPT5H Antibodies)]
These findings reveal a dynamic regulation of DSIF (show SUPT5H Antibodies) involving either E-box or NF-kappaB (show NFKB1 Antibodies) depending on the physiological circumstances.
Spt4 was purified and characterized.
These results suggest that one of the functions of Spt5 is to suppress senescence and apoptosis, and that this function is exerted through its association with Spt4 and Pol II.
he Paf1 (show PEX2 Antibodies) complex (Paf1C) and Tat-SF1 (show HTATSF1 Antibodies), two factors implicated previously in elongation control, collaborate with DSIF (show SUPT5H Antibodies) to facilitate efficient elongation
reduction of SUPT4H in mouse brains is associated with decreased HTT (show HTT Antibodies) protein aggregation, and in R6/2 mice, also with prolonged lifespan and delay of the motor impairment that normally develops in these animals.
our findings indicate that Spt4 and Spt5 (show SUPT5H Antibodies) have essential functions in the DNA repair phase of immunoglobulin class switch recombination.
These findings indicate that Supt4h is differentially required for expression of the mutant Htt (show HTT Antibodies) allele in mouse striatal neurons.
This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene.
, DRB sensitivity-inducing factor small subunit
, DSIF small subunit
, transcription elongation factor SPT4
, DRB sensitivity-inducing factor 14 kDa subunit
, DSIF p14
, small hSpt4 subunit
, suppressor of Ty 4 homolog 1
, suppressor of Ty 4 homolog 2
, DRB sensitivity-inducing factor small subunit 1
, DSIF small subunit 1
, transcription elongation factor SPT4 1
, transcription elongation factor SPT4-A
, hypothetical protein