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Suppressor of Variegation 3-9 Homolog 2 (Drosophila) Proteins (SUV39H2)

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Additionally we are shipping SUV39H2 Antibodies (110) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SUV39H2 79723 Q9H5I1
SUV39H2 64707 Q9EQQ0
Rat SUV39H2 SUV39H2 364785  
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Top SUV39H2 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$3,125.83
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,129.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,138.67
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,138.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 50 μg Log in to see 1 to 2 Days
$455.00
Details

SUV39H2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2) Interaction Partners

Human Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2) interaction partners

  1. Our results reveal the regulatory mechanism of LSD1 (show KDM1A Proteins) protein through its lysine methylation by SUV39H2 in human cancer cells

  2. We also demonstrate that the N324K mutant in the SET domain of SUV39H2 that has been shown to cause an inherited nasal skin disease in Labrador Retrievers renders SUV39H2 inactive

  3. Expression of JHDM2A (show KDM3A Proteins) was significantly increased but HDAC2 (show HDAC2 Proteins), HDAC7 (show HDAC7 Proteins), and SUV39H2 were significantly down-regulated in Systemic Sclerosis B cells relative to controls

  4. genetic association studies in a Finnish population with type I diabetes: The minor T allele of exonic SNP rs17353856 in SUV39H2 is associated with diabetic retinopathy (in a larger meta-analysis); thus an genetic variation may be protective.

  5. findings suggest that Suv39H1 (show SUV39H1 Proteins) and Suv39H2 are key hypoxia-induced methyltransferases; their decline in fetal lung during late gestation is critical for epigenetic changes resulting in the developmental induction of SP-A

  6. a novel SUV39H2 polymorphism may have a role in lung cancer susceptibility for smokers

  7. The SUV39H2 gene is found in tetrapods (e.g., human, mouse and frog) but not in zebrafish, suggesting that this gene is generated by a tetrapod lineage-specific gene duplication event.

Pig (Porcine) Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2) interaction partners

  1. Knockdown of SUV39H1 (show SUV39H1 Proteins) and SUV39H2 in embryonic stem-like cells and embryonic fibroblasts increases telomere length.

Mouse (Murine) Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2) interaction partners

  1. Repeat-associated, Suv39h (show SUV39H1 Proteins)-dependent H3K9me3 displays a dynamic distribution that differs in the epigenome of pluripotent versus more committed cells.

  2. ESET (show SETDB1 Proteins) histone methyltransferase can form a large, multi-protein complex(es) with mSin3A/B co-repressors and HDAC1 (show HDAC1 Proteins)/2 that participates in multiple pathways of transcriptional repression.

  3. Taken together, the results indicate epigenetic regulation of telomere length in mammals by Suv39h1 (show SUV39H1 Proteins) and Suv39h2.

SUV39H2 Protein Profile

Protein Summary

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes (By similarity).

Gene names and symbols associated with SUV39H2

  • suppressor of variegation 3-9 homolog 2 (Drosophila) (SUV39H2)
  • suppressor of variegation 3-9 homolog 2 (suv39h2)
  • similar to Histone-lysine N-methyltransferase, H3 lysine-9 specific 2 (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) (SUV39H2)
  • suppressor of variegation 3-9 homolog 2 (Drosophila) (Suv39h2)
  • 4930507K23Rik protein
  • AA536750 protein
  • D030054H19Rik protein
  • D2Ertd544e protein
  • KMT1B protein
  • SUV39H2 protein

Protein level used designations for SUV39H2

suppressor of variegation 3-9 homolog 2 (Drosophila) , histone-lysine N-methyltransferase SUV39H2 , su(var)3-9 homolog 2 , histone-lysine N-methyltransferase SUV39H2-like , H3-K9-HMTase 2 , histone H3-K9 methyltransferase 2 , lysine N-methyltransferase 1B , Suv39h histone methyltransferase

GENE ID SPECIES
466014 Pan troglodytes
549262 Xenopus (Silurana) tropicalis
697378 Macaca mulatta
698451 Macaca mulatta
100037174 Xenopus laevis
100401513 Callithrix jacchus
100436926 Pongo abelii
100469547 Ailuropoda melanoleuca
100591032 Nomascus leucogenys
79723 Homo sapiens
477995 Canis lupus familiaris
664651 Sus scrofa
536936 Bos taurus
64707 Mus musculus
364785 Rattus norvegicus
426314 Gallus gallus
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