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Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Additionally we are shipping SUV39H2 Antibodies (108) and many more products for this protein.
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Our results reveal the regulatory mechanism of LSD1 (show KDM1A Proteins) protein through its lysine methylation by SUV39H2 in human cancer cells
We also demonstrate that the N324K mutant in the SET domain of SUV39H2 that has been shown to cause an inherited nasal skin disease in Labrador Retrievers renders SUV39H2 inactive
Expression of JHDM2A (show KDM3A Proteins) was significantly increased but HDAC2 (show HDAC2 Proteins), HDAC7 (show HDAC7 Proteins), and SUV39H2 were significantly down-regulated in Systemic Sclerosis B cells relative to controls
genetic association studies in a Finnish population with type I diabetes: The minor T allele of exonic SNP rs17353856 in SUV39H2 is associated with diabetic retinopathy (in a larger meta-analysis); thus an genetic variation may be protective.
findings suggest that Suv39H1 (show SUV39H1 Proteins) and Suv39H2 are key hypoxia-induced methyltransferases; their decline in fetal lung during late gestation is critical for epigenetic changes resulting in the developmental induction of SP-A
a novel SUV39H2 polymorphism may have a role in lung cancer susceptibility for smokers
The SUV39H2 gene is found in tetrapods (e.g., human, mouse and frog) but not in zebrafish, suggesting that this gene is generated by a tetrapod lineage-specific gene duplication event.
Knockdown of SUV39H1 (show SUV39H1 Proteins) and SUV39H2 in embryonic stem-like cells and embryonic fibroblasts increases telomere length.
Repeat-associated, Suv39h (show SUV39H1 Proteins)-dependent H3K9me3 displays a dynamic distribution that differs in the epigenome of pluripotent versus more committed cells.
ESET (show SETDB1 Proteins) histone methyltransferase can form a large, multi-protein complex(es) with mSin3A/B co-repressors and HDAC1 (show HDAC1 Proteins)/2 that participates in multiple pathways of transcriptional repression.
Taken together, the results indicate epigenetic regulation of telomere length in mammals by Suv39h1 (show SUV39H1 Proteins) and Suv39h2.
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes (By similarity).
suppressor of variegation 3-9 homolog 2 (Drosophila)
, histone-lysine N-methyltransferase SUV39H2
, su(var)3-9 homolog 2
, histone-lysine N-methyltransferase SUV39H2-like
, H3-K9-HMTase 2
, histone H3-K9 methyltransferase 2
, lysine N-methyltransferase 1B
, Suv39h histone methyltransferase