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SUV420H1 encodes a protein that contains a SET domain. Additionally we are shipping Suppressor of Variegation 4-20 Homolog 1 (Drosophila) Antibodies (50) and many more products for this protein.
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Altogether, these results reveal Suv4-20h-mediated histone H4K20 tri (show VANGL2 Proteins)-methylation as a critical determinant in the selection of active replication initiation sites in heterochromatin regions of mammalian genomes.
overexpression of SUV420H1 may result in activation of the ERK (show EPHB2 Proteins) signaling pathway
Strong statistical evidence for a causal role of SUV420H1 in autism.
This study suggests a novel role of FRG1 (show FRG1 Proteins) as epigenetic regulator of muscle differentiation and indicates that Suv4-20h1 has a gene-specific function in myogenesis.
The crystal structure of SUV420H1 was used to characterize substrate selectivity and product specificity.
SUV420H1 and SUV420H2 (show SUV420H2 Proteins) isoforms have different in their cellular localization and effects on myogenic differentiation
dissect the GRIP1 (show NCOA2 Proteins):Suv4-20h1 interaction in vitro and in vivo and examine its potential involvement in hormone-dependent transcriptional regulation by GR
Suv4-20h1/h2 are mostly absent in mouse embryos before implantation, underscoring a rapid decrease of H4K20me3 from the two-cell stage onward
Suv4-20h1, an H4K20 dimethyltransferase, controls Skeletal muscle stem cell quiescence by promoting formation of facultative heterochromatin.
Data suggest that Suv4-20h1/Suv4-20h2 (show SUV420H2 Proteins) activity is required for fidelity of chromosome distribution during meiosis in oocyte; Suv4-20h1/Suv4-20h2 (show SUV420H2 Proteins) appear to control histone 4 methylation, centromere structure, and oocyte maturation/oogenesis.
murine Suv4-20h1/h2 double-knockout embryonic stem (DKO ES) cells exhibit increased Oct4 (show POU5F1 Proteins) protein levels before and during EB formation, and reveal a compromised and biased capacity for in vitro differentiation, when compared to normal ES cells
This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Two alternatively spliced transcript variants have been found for this gene.
suppressor of variegation 4-20 homolog 1 (Drosophila)
, histone-lysine N-methyltransferase SUV420H1
, su(var)4-20 homolog 1
, suppressor of variegation 4-20 protein-like 1
, histone-lysine N-methyltransferase SUV420H1-like
, histone-lysine N-methyltransferase SUV420H1-A
, su(var)4-20 homolog 1-A
, suppressor of variegation 4-20 homolog 1-A
, suv4-20 h1
, lysine N-methyltransferase 5B