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anti-Suppressor of Zeste 12 Homolog (Drosophila) (SUZ12) Antibodies

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse SUZ12 SUZ12 52615 Q80U70
Anti-Human SUZ12 SUZ12 23512 Q15022
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More Antibodies against Suppressor of Zeste 12 Homolog (Drosophila) Interaction Partners

Xenopus laevis Suppressor of Zeste 12 Homolog (Drosophila) (SUZ12) interaction partners

Mouse (Murine) Suppressor of Zeste 12 Homolog (Drosophila) (SUZ12) interaction partners

  1. Although Suz12 was required for lymphoid development, deletion in individual blood cell lineages revealed that it was dispensable for the development of granulocytic, monocytic, and megakaryocytic cells.

  2. Suz12-dependent recruitment of Tet1 (show TET1 Antibodies) contributes to epigenetic plasticity throughout cell differentiation.

  3. PRC2 is a tumor suppressor in Emicro-myc (show MYC Antibodies) lymphomagenesis, because disease onset was accelerated by heterozygosity for Suz12 or by short hairpin RNA-mediated knockdown of Suz12 or Ezh2 (show EZH2 Antibodies).

  4. PRC2 supports aberrant self-renewal in a mouse model of MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies);Nras (show NRAS Antibodies)(G12D) acute myeloid leukemia (show BCL11A Antibodies).

  5. The distinct expression profile of the identified Suz12 repressed genes in combination with the proliferation genes hold promise as biomarkers for progression of chronic Hepatitis B V infection to Hepatocellular Carcinoma.

  6. polycomb (show CBX2 Antibodies) proteins BMI1 (show BMI1 Antibodies) and SUZ12 are required for cell transformation induced by organic arsenic exposure

  7. Data indicate that binding of EZH2 (show EZH2 Antibodies), SUZ12 and EED (show EED Antibodies), the 3 subunits of Plybomb repressive complex 2 (PRC2), is required for PRC2 full activity, and late during viral infection, a significant increase in PRC2 protein association with chromatin.

  8. identify polycomb-like 2 (show MTF2 Antibodies) and Polycomb (show CBX2 Antibodies) Repressive Complex 2 transcriptional targets and draft regulatory networks.[Polycomb (show CBX2 Antibodies) Repressive Complex 2 and polycomb-like 2 (show MTF2 Antibodies)]

  9. Data show that RARgamma is required for deposition of H2A.Z (show H2AFZ Antibodies) and Suz12 at RA target genes, and that in embryonic stem cells both RARgamma and Suz12 exist in a multi-protein complex in the absence of ligand.

  10. Quantitative mass spectrometry was used to investigate the effects of Suz12 deficiency on H3.2 and H3.3 from mouse embryonic stem cells.

Human Suppressor of Zeste 12 Homolog (Drosophila) (SUZ12) interaction partners

  1. Activation of EZH2 (show EZH2 Antibodies) and SUZ12 Regulated by E2F1 (show E2F1 Antibodies) Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer

  2. Data show that RAS protein activation was the initiating oncogenic event, with polycomb (show CBX2 Antibodies) repressive complex 2 (PRC2) subunits impairment being a secondary event.

  3. SUZ12 is a key molecule in the regulation of monoallelic expression of IGF2.

  4. Overexpression of Suz12 was associated with lung adenocarcinoma.

  5. this study described that miR (show MLXIP Antibodies)-489 expression level was significantly reduced in lung cancer samples (n = 115) and cell lines. Abnormal expression of miR (show MLXIP Antibodies)-489 regulated the cells invasion by binding SUZ12 3'-UTR (show UTS2R Antibodies) in vitro.

  6. Upregulation of SUZ12 was found to play a key role in gastric cancer cell proliferation and metastasis through the regulation of EMT (show ITK Antibodies) and KLF2 (show KLF2 Antibodies) expression

  7. downregulation of SUZ12 and ZNF198 (show ZMYM2 Antibodies) leads to epigenetic reprogramming of infected hepatocytes. Because both Plk1 (show PLK1 Antibodies) and HOTAIR are elevated in many human cancers, we propose that their combined effects are involved in epigenetic reprogramming

  8. Conclude that the expression of SUZ12 is increased along with the degree of infiltration and metastasis of gastric carcinoma.

  9. Data show that overall enhancer of zeste 2 (EZH2 (show EZH2 Antibodies)), embryonic ectoderm development (EED (show EED Antibodies)) and suppressor of zeste 12 homolog (SUZ12) expression in the colorectal cancer (CRC (show CALR Antibodies)) tissues was significantly increased than in the non-cancerous tissue.

  10. Somatic mutations of SUZ12 have a central role in malignant transformation of peripheral nerve sheath tumors.

Suppressor of Zeste 12 Homolog (Drosophila) (SUZ12) Antigen Profile

Protein Summary

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.

Gene names and symbols associated with SUZ12

  • SUZ12 polycomb repressive complex 2 subunit (suz12) antibody
  • suppressor of zeste 12 homolog (Drosophila) (SUZ12) antibody
  • suppressor of zeste 12 homolog (Drosophila) (LOC100228788) antibody
  • suppressor of zeste 12 (suz12) antibody
  • suppressor of zeste 12 homolog (Drosophila) (Suz12) antibody
  • SUZ12 polycomb repressive complex 2 subunit (SUZ12) antibody
  • 2610028O16Rik antibody
  • AI195385 antibody
  • AU016842 antibody
  • AW536442 antibody
  • CHET9 antibody
  • D11Ertd530e antibody
  • JJAZ1 antibody
  • mKIAA0160 antibody
  • SUZ12 antibody
  • Xsuz12 antibody

Protein level used designations for SUZ12

Suppressor of zeste 12 protein homolog , polycomb protein suz12 , suppressor of zeste 12 homolog , suppressor of zeste 12 homolog (Drosophila) , joined to JAZF1 , polycomb protein SUZ12 , polycomb protein Suz12 , suppressor of zeste 12 protein homolog , chET 9 protein , chromatin precipitated E2F target 9 protein , joined to JAZF1 protein

GENE ID SPECIES
779745 Xenopus (Silurana) tropicalis
748393 Pan troglodytes
100080410 Ornithorhynchus anatinus
100228788 Taeniopygia guttata
100547545 Meleagris gallopavo
100607575 Nomascus leucogenys
100329217 Xenopus laevis
100294712 Sus scrofa
538774 Bos taurus
52615 Mus musculus
417406 Gallus gallus
491158 Canis lupus familiaris
23512 Homo sapiens
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