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This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma.
Although Suz12 was required for lymphoid development, deletion in individual blood cell lineages revealed that it was dispensable for the development of granulocytic, monocytic, and megakaryocytic cells.
Suz12-dependent recruitment of Tet1 contributes to epigenetic plasticity throughout cell differentiation.
PRC2 is a tumor suppressor in Emicro-myc (show MYC ELISA Kits) lymphomagenesis, because disease onset was accelerated by heterozygosity for Suz12 or by short hairpin RNA-mediated knockdown of Suz12 or Ezh2 (show EZH2 ELISA Kits).
PRC2 supports aberrant self-renewal in a mouse model of MLL (show MLL ELISA Kits)-AF9 (show MLLT3 ELISA Kits);Nras (show NRAS ELISA Kits)(G12D) acute myeloid leukemia (show BCL11A ELISA Kits).
The distinct expression profile of the identified Suz12 repressed genes in combination with the proliferation genes hold promise as biomarkers for progression of chronic Hepatitis B V infection to Hepatocellular Carcinoma.
polycomb (show CBX2 ELISA Kits) proteins BMI1 (show BMI1 ELISA Kits) and SUZ12 are required for cell transformation induced by organic arsenic exposure
Data indicate that binding of EZH2 (show EZH2 ELISA Kits), SUZ12 and EED (show EED ELISA Kits), the 3 subunits of Plybomb repressive complex 2 (PRC2), is required for PRC2 full activity, and late during viral infection, a significant increase in PRC2 protein association with chromatin.
identify polycomb-like 2 and Polycomb Repressive Complex 2 transcriptional targets and draft regulatory networks.[Polycomb Repressive Complex 2 and polycomb-like 2]
Data show that RARgamma is required for deposition of H2A.Z (show H2AFZ ELISA Kits) and Suz12 at RA target genes, and that in embryonic stem cells both RARgamma and Suz12 exist in a multi-protein complex in the absence of ligand.
Quantitative mass spectrometry was used to investigate the effects of Suz12 deficiency on H3.2 and H3.3 from mouse embryonic stem cells.
Activation of EZH2 (show EZH2 ELISA Kits) and SUZ12 Regulated by E2F1 (show E2F1 ELISA Kits) Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer
Data show that RAS protein activation was the initiating oncogenic event, with polycomb (show CBX2 ELISA Kits) repressive complex 2 (PRC2) subunits impairment being a secondary event.
SUZ12 is a key molecule in the regulation of monoallelic expression of IGF2.
Overexpression of Suz12 was associated with lung adenocarcinoma.
this study described that miR (show MLXIP ELISA Kits)-489 expression level was significantly reduced in lung cancer samples (n = 115) and cell lines. Abnormal expression of miR (show MLXIP ELISA Kits)-489 regulated the cells invasion by binding SUZ12 3'-UTR (show UTS2R ELISA Kits) in vitro.
Upregulation of SUZ12 was found to play a key role in gastric cancer cell proliferation and metastasis through the regulation of EMT (show ITK ELISA Kits) and KLF2 (show KLF2 ELISA Kits) expression
downregulation of SUZ12 and ZNF198 (show ZMYM2 ELISA Kits) leads to epigenetic reprogramming of infected hepatocytes. Because both Plk1 (show PLK1 ELISA Kits) and HOTAIR are elevated in many human cancers, we propose that their combined effects are involved in epigenetic reprogramming
Conclude that the expression of SUZ12 is increased along with the degree of infiltration and metastasis of gastric carcinoma.
Data show that overall enhancer of zeste 2 (EZH2 (show EZH2 ELISA Kits)), embryonic ectoderm development (EED (show EED ELISA Kits)) and suppressor of zeste 12 homolog (SUZ12) expression in the colorectal cancer (CRC (show CALR ELISA Kits)) tissues was significantly increased than in the non-cancerous tissue.
Somatic mutations of SUZ12 have a central role in malignant transformation of peripheral nerve sheath tumors.
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.
Suppressor of zeste 12 protein homolog
, polycomb protein suz12
, suppressor of zeste 12 homolog
, suppressor of zeste 12 homolog (Drosophila)
, joined to JAZF1
, polycomb protein SUZ12
, polycomb protein Suz12
, suppressor of zeste 12 protein homolog
, chET 9 protein
, chromatin precipitated E2F target 9 protein
, joined to JAZF1 protein