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This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma.
Although Suz12 was required for lymphoid development, deletion in individual blood cell lineages revealed that it was dispensable for the development of granulocytic, monocytic, and megakaryocytic cells.
Suz12-dependent recruitment of Tet1 (show TET1 Proteins) contributes to epigenetic plasticity throughout cell differentiation.
PRC2 is a tumor suppressor in Emicro-myc (show MYC Proteins) lymphomagenesis, because disease onset was accelerated by heterozygosity for Suz12 or by short hairpin RNA-mediated knockdown of Suz12 or Ezh2 (show EZH2 Proteins).
PRC2 supports aberrant self-renewal in a mouse model of MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins);Nras (show NRAS Proteins)(G12D) acute myeloid leukemia (show BCL11A Proteins).
The distinct expression profile of the identified Suz12 repressed genes in combination with the proliferation genes hold promise as biomarkers for progression of chronic Hepatitis B V infection to Hepatocellular Carcinoma.
polycomb (show CBX2 Proteins) proteins BMI1 (show BMI1 Proteins) and SUZ12 are required for cell transformation induced by organic arsenic exposure
Data indicate that binding of EZH2 (show EZH2 Proteins), SUZ12 and EED (show EED Proteins), the 3 subunits of Plybomb repressive complex 2 (PRC2), is required for PRC2 full activity, and late during viral infection, a significant increase in PRC2 protein association with chromatin.
identify polycomb-like 2 (show MTF2 Proteins) and Polycomb (show CBX2 Proteins) Repressive Complex 2 transcriptional targets and draft regulatory networks.[Polycomb (show CBX2 Proteins) Repressive Complex 2 and polycomb-like 2 (show MTF2 Proteins)]
Data show that RARgamma is required for deposition of H2A.Z (show H2AFZ Proteins) and Suz12 at RA target genes, and that in embryonic stem cells both RARgamma and Suz12 exist in a multi-protein complex in the absence of ligand.
Quantitative mass spectrometry was used to investigate the effects of Suz12 deficiency on H3.2 and H3.3 from mouse embryonic stem cells.
Activation of EZH2 (show EZH2 Proteins) and SUZ12 Regulated by E2F1 (show E2F1 Proteins) Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer
Data show that RAS protein activation was the initiating oncogenic event, with polycomb (show CBX2 Proteins) repressive complex 2 (PRC2) subunits impairment being a secondary event.
SUZ12 is a key molecule in the regulation of monoallelic expression of IGF2.
Overexpression of Suz12 was associated with lung adenocarcinoma.
this study described that miR-489 expression level was significantly reduced in lung cancer samples (n = 115) and cell lines. Abnormal expression of miR-489 regulated the cells invasion by binding SUZ12 3'-UTR in vitro.
Upregulation of SUZ12 was found to play a key role in gastric cancer cell proliferation and metastasis through the regulation of EMT (show ITK Proteins) and KLF2 (show KLF2 Proteins) expression
downregulation of SUZ12 and ZNF198 leads to epigenetic reprogramming of infected hepatocytes. Because both Plk1 and HOTAIR are elevated in many human cancers, we propose that their combined effects are involved in epigenetic reprogramming
Conclude that the expression of SUZ12 is increased along with the degree of infiltration and metastasis of gastric carcinoma.
Data show that overall enhancer of zeste 2 (EZH2 (show EZH2 Proteins)), embryonic ectoderm development (EED (show EED Proteins)) and suppressor of zeste 12 homolog (SUZ12) expression in the colorectal cancer (CRC (show CALR Proteins)) tissues was significantly increased than in the non-cancerous tissue.
Somatic mutations of SUZ12 have a central role in malignant transformation of peripheral nerve sheath tumors.
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.
Suppressor of zeste 12 protein homolog
, polycomb protein suz12
, suppressor of zeste 12 homolog
, suppressor of zeste 12 homolog (Drosophila)
, joined to JAZF1
, polycomb protein SUZ12
, polycomb protein Suz12
, suppressor of zeste 12 protein homolog
, chET 9 protein
, chromatin precipitated E2F target 9 protein
, joined to JAZF1 protein