Suppressor of Zeste 12 Homolog (Drosophila) Proteins (SUZ12)

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma.

list all proteins Gene Name GeneID UniProt
Mouse SUZ12 SUZ12 52615 Q80U70
Human SUZ12 SUZ12 23512 Q15022
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More Proteins for Suppressor of Zeste 12 Homolog (Drosophila) (SUZ12) Interaction Partners

Xenopus laevis Suppressor of Zeste 12 Homolog (Drosophila) (SUZ12) interaction partners

Mouse (Murine) Suppressor of Zeste 12 Homolog (Drosophila) (SUZ12) interaction partners

  1. Biochemical as well as functional experiments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 (show EZH2 Proteins) to Suz12 and reduce PRC2 chromatin engagement.

  2. lncRNA OL1 interacts with Suz12-PRC2 complex to orchestrate the oligodendrocyte differentiation program.

  3. in the skin epithelium, EED (show EED Proteins), Suz12, and Ezh1 (show EZH1 Proteins)/2 function largely as subunits of the PRC2 complex and have roles in skin development

  4. Although Suz12 was required for lymphoid development, deletion in individual blood cell lineages revealed that it was dispensable for the development of granulocytic, monocytic, and megakaryocytic cells.

  5. Suz12-dependent recruitment of Tet1 (show TET1 Proteins) contributes to epigenetic plasticity throughout cell differentiation.

  6. PRC2 is a tumor suppressor in Emicro-myc (show MYC Proteins) lymphomagenesis, because disease onset was accelerated by heterozygosity for Suz12 or by short hairpin RNA-mediated knockdown of Suz12 or Ezh2 (show EZH2 Proteins).

  7. PRC2 supports aberrant self-renewal in a mouse model of MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins);Nras (show NRAS Proteins)(G12D) acute myeloid leukemia (show BCL11A Proteins).

  8. The distinct expression profile of the identified Suz12 repressed genes in combination with the proliferation genes hold promise as biomarkers for progression of chronic Hepatitis B V infection to Hepatocellular Carcinoma.

  9. polycomb (show CBX2 Proteins) proteins BMI1 (show BMI1 Proteins) and SUZ12 are required for cell transformation induced by organic arsenic exposure

  10. Data indicate that binding of EZH2 (show EZH2 Proteins), SUZ12 and EED (show EED Proteins), the 3 subunits of Plybomb repressive complex 2 (PRC2), is required for PRC2 full activity, and late during viral infection, a significant increase in PRC2 protein association with chromatin.

Human Suppressor of Zeste 12 Homolog (Drosophila) (SUZ12) interaction partners

  1. PRE-PIK3C2B (show PIK3C2B Proteins) interacts directly with YY1 (show YY1 Proteins) in vitro and recruits PRC2 complex in vivo. The localization of PcG proteins including YY1 (show YY1 Proteins) to PRE-PIK3C2B (show PIK3C2B Proteins) in HEK (show EPHA3 Proteins) cells is decreased on knock-down of either YY1 (show YY1 Proteins) or SUZ12.

  2. EZH1 (show EZH1 Proteins), SUZ12 and UXT (show UXT Proteins) work synergistically to regulate pathway activation in the nucleus.

  3. Mutation in the SUZ12 gene is associated with malignant peripheral nerve sheath tumors.

  4. Overexpression of miR (show MLXIP Proteins)-105 inhibited cell proliferation, tumorigenesis, migration, invasion, and drug sensitivity, whereas overexpression of suppressor of Zeste 12 homolog antagonized the tumor-suppressive functions of miR (show MLXIP Proteins)-105.

  5. Mutations of SUZ12 and EED (show EED Proteins) are reported to have tumor suppressive functions. (Review)

  6. The difference in the SUZ12 and CBX8 (show CBX8 Proteins) genes expression were significantly divergent between tumors and their marginal tissues.

  7. Activation of EZH2 (show EZH2 Proteins) and SUZ12 Regulated by E2F1 (show E2F1 Proteins) Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer

  8. Data show that RAS protein activation was the initiating oncogenic event, with polycomb (show CBX2 Proteins) repressive complex 2 (PRC2) subunits impairment being a secondary event.

  9. SUZ12 is a key molecule in the regulation of monoallelic expression of IGF2.

  10. Overexpression of Suz12 was associated with lung adenocarcinoma.

Suppressor of Zeste 12 Homolog (Drosophila) (SUZ12) Protein Profile

Protein Summary

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.

Gene names and symbols associated with SUZ12

  • SUZ12 polycomb repressive complex 2 subunit (suz12)
  • suppressor of zeste 12 homolog (Drosophila) (SUZ12)
  • suppressor of zeste 12 homolog (Drosophila) (LOC100228788)
  • suppressor of zeste 12 (suz12)
  • suppressor of zeste 12 homolog (Drosophila) (Suz12)
  • SUZ12 polycomb repressive complex 2 subunit (SUZ12)
  • 2610028O16Rik protein
  • AI195385 protein
  • AU016842 protein
  • AW536442 protein
  • CHET9 protein
  • D11Ertd530e protein
  • JJAZ1 protein
  • mKIAA0160 protein
  • SUZ12 protein
  • Xsuz12 protein

Protein level used designations for SUZ12

Suppressor of zeste 12 protein homolog , polycomb protein suz12 , suppressor of zeste 12 homolog , suppressor of zeste 12 homolog (Drosophila) , joined to JAZF1 , polycomb protein SUZ12 , polycomb protein Suz12 , suppressor of zeste 12 protein homolog , chET 9 protein , chromatin precipitated E2F target 9 protein , joined to JAZF1 protein

GENE ID SPECIES
779745 Xenopus (Silurana) tropicalis
748393 Pan troglodytes
100080410 Ornithorhynchus anatinus
100228788 Taeniopygia guttata
100547545 Meleagris gallopavo
100607575 Nomascus leucogenys
100329217 Xenopus laevis
100294712 Sus scrofa
538774 Bos taurus
52615 Mus musculus
417406 Gallus gallus
491158 Canis lupus familiaris
23512 Homo sapiens
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