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Surfactant Associated Protein C (SFTPC) ELISA Kits

SFTPC encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Additionally we are shipping SFTPC Antibodies (10) and SFTPC Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse SFTPC SFTPC 20389  
SFTPC 6440 P11686
SFTPC 50683 P11685
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Showing 2 out of 4 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 0.112 ng/mL 0.313-20 ng/mL 96 Tests Log in to see 9 to 16 Days
Rat 0.135 ng/mL 0.313-20 ng/mL 96 Tests Log in to see 9 to 16 Days

More ELISA Kits for SFTPC Interaction Partners

Mouse (Murine) Surfactant Associated Protein C (SFTPC) interaction partners

  1. Data suggests that different SP-C mutations have unique consequences for interstitial lung diseases. Mutations here resulted in aberrant proSP-c products

  2. In vivo deficiency of SP-C leads to inflammation, increased cytokine production by type II cells, and persistent inflammation after repetitive LPS (show TLR4 ELISA Kits) stimulation.

  3. Transgenic restoration of SP-C reduces inflammation and improves viral clearance in the lungs of SP-C deficient mice.

  4. The SPC H2B-GFP allele allowed the FACS-based enrichment and gene expression profiling of AT2 cells.

  5. misfolded surfactant protein C has a role in endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells

  6. Cytoprotective-selective activated protein C (show PROC ELISA Kits) attenuates Pseudomonas aeruginosa-induced lung injury in mice

  7. The differential expression of mRNA by both airway level and lung region was determined for surfactant protein C.

  8. To target type II alveolar epithelial cells with this model, we generated transgenic mice that express DTR (show HBEGF ELISA Kits) off of the type II cell-specific surfactant protein C (SPC) promoter.

  9. Nedd4-2-mediated ubiquitination regulates lumenal relocation of SP-C, leading to processing and, ultimately, secretion of SP-C.

  10. pulmonary surfactant protein C binds with CD14 (show CD14 ELISA Kits) and lipopolysaccharide

Human Surfactant Associated Protein C (SFTPC) interaction partners

  1. Rare mutations in surfactant-associated genes contribute to neonatal respiratory distress syndrome. The frequency of mutations in these genes in the Chinese population is unknown. We resequenced all exons of the surfactant protein-C (SFTPC) and we did not find any rare mutations in SFTPC

  2. In interstitial lung disease, abnormal proSP-C was seen in small and dense lamellar bodies in type II alveolar epithelial cells. A549 cells expressing proSP-C(L55F) had abnormal organelles. It partly colocalized in CD63 (show CD63 ELISA Kits)-positive cytoplasmic vesicles .

  3. We sequenced SFTPC and analyzed morphology, ultrastructure and SP expression in lung tissue when available. We identified eight subjects who were heterozygous for SP-C mutations.

  4. analysis of clinical patterns in patients with SFTPC mutations

  5. support a chaperone function of the BRICHOS domain, possibly together with the linker region, during pro-SP-C biosynthesis in the endoplasmic reticulum

  6. cleavage of BRICHOS in a loop region that is cleaved during proSP-C biosynthesis results in increased capacity to delay Abeta (show APP ELISA Kits)(42) fibril formation.

  7. Structural modeling of transmembrane (BRICHOS) domains of SFTPC precursor and BRI2/ITM2B (integral membrane protein 2B (show ITM2B ELISA Kits)) identifies conserved region structurally complementary to beta-sheet-/amyloid-prone regions in BRICHOS domain-containing proteins.

  8. (surfactant protein C), a specific functional marker of human type II alveolar epithelial cells, was detected in differentiated cells by RT-PCR (reverse transcription-PCR) analysis after day 15.

  9. Several genetic abnormalities have been associated with familial pulmonary fibrosis. The present study examined the genes coding for surfactant protein-C, ATPbinding cassette protein A3 and telomerase, and found no abnormalities.

  10. Mutation increases endoplasmic reticulum stress and induces apoptotic cell death compared with wild-type SP-C in alveolar type II cells, supporting the significance of this mutation in the pathogenesis of pulmonary fibrosis.

SFTPC Antigen Profile

Antigen Summary

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.

Gene names and symbols associated with SFTPC

  • surfactant associated protein C (Sftpc) antibody
  • surfactant protein C (SFTPC) antibody
  • surfactant protein C (Sftpc) antibody
  • BRICD6 antibody
  • pro-SpC antibody
  • PSP-C antibody
  • Sftp-2 antibody
  • SFTP2 antibody
  • SMDP2 antibody
  • SP-C antibody
  • SP5 antibody
  • SPC antibody

Protein level used designations for SFTPC

pulmonary surfactant-associated protein C , pulmonary surfactant-associated proteolipid SPL(Val) , BRICHOS domain containing 6 , SP5 , pulmonary surfactant apoprotein-2 SP-C , Surfactant pulmonary-associated protein C , Surfactant, pulmonary-associated protein C , surfactant associated protein C

20389 Mus musculus
6440 Homo sapiens
50683 Rattus norvegicus
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