Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
SFTPC encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Additionally we are shipping Surfactant Protein C Antibodies (120) and Surfactant Protein C Proteins (9) and many more products for this protein.
Showing 10 out of 47 products:
Human Surfactant Protein C ELISA Kit for Sandwich ELISA - ABIN365768
Uhl, Vierkotten, Wagner, Burgstaller, Costa, Koch, Lindner, Meiners, Eickelberg, Königshoff: Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures. in The European respiratory journal 2015
Show all 2 Pubmed References
Mouse (Murine) Surfactant Protein C ELISA Kit for Sandwich ELISA - ABIN424973
Zhang, Zhao, Yuan, Wu, Jiang, Zhao, Luo, Xue: Autophagy regulates hyperoxia-induced intracellular accumulation of surfactant protein C in alveolar type II cells. in Molecular and cellular biochemistry 2015
an intricate link between caveolin-1 (show CAV1 ELISA Kits) and Src kinase (show CSK ELISA Kits)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C expression through p53 (show TP53 ELISA Kits) and uPA (show PLAU ELISA Kits) system-mediated cross-talk, is reported.
Data suggests that different SP-C mutations have unique consequences for interstitial lung diseases. Mutations here resulted in aberrant proSP-c products
In vivo deficiency of SP-C leads to inflammation, increased cytokine production by type II cells, and persistent inflammation after repetitive LPS (show TLR4 ELISA Kits) stimulation.
Transgenic restoration of SP-C reduces inflammation and improves viral clearance in the lungs of SP-C deficient mice.
The SPC H2B-GFP allele allowed the FACS-based enrichment and gene expression profiling of AT2 cells.
misfolded surfactant protein C has a role in endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells
Cytoprotective-selective activated protein C (show PROC ELISA Kits) attenuates Pseudomonas aeruginosa-induced lung injury in mice
The differential expression of mRNA by both airway level and lung region was determined for surfactant protein C.
To target type II alveolar epithelial cells with this model, we generated transgenic mice that express DTR (show HBEGF ELISA Kits) off of the type II cell-specific surfactant protein C (SPC) promoter.
Nedd4-2-mediated ubiquitination regulates lumenal relocation of SP-C, leading to processing and, ultimately, secretion of SP-C.
c.435G>C variant in the SFTPC gene associated with fatal neonatal respiratory distress syndrome. The c.435G>C mutation is deleterious not because of its amino acid substitution but because of its subsequent splicing defect and should be referred to as r.325_435del and p.Leu109_Gln145del.
an intricate link between caveolin-1 (show CAV1 ELISA Kits) and Src kinase (show CSK ELISA Kits)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C expression through p53 (show TP53 ELISA Kits) and uPA (show PRAP1 ELISA Kits) system-mediated cross-talk, is reported.
Rare mutations in surfactant-associated genes contribute to neonatal respiratory distress syndrome. The frequency of mutations in these genes in the Chinese population is unknown. We resequenced all exons of the surfactant protein-C (SFTPC) and we did not find any rare mutations in SFTPC
In interstitial lung disease, abnormal proSP-C was seen in small and dense lamellar bodies in type II alveolar epithelial cells. A549 cells expressing proSP-C(L55F) had abnormal organelles. It partly colocalized in CD63 (show CD63 ELISA Kits)-positive cytoplasmic vesicles .
We sequenced SFTPC and analyzed morphology, ultrastructure and SP expression in lung tissue when available. We identified eight subjects who were heterozygous for SP-C mutations.
analysis of clinical patterns in patients with SFTPC mutations
support a chaperone function of the BRICHOS domain, possibly together with the linker region, during pro-SP-C biosynthesis in the endoplasmic reticulum
cleavage of BRICHOS in a loop region that is cleaved during proSP-C biosynthesis results in increased capacity to delay Abeta (show APP ELISA Kits)(42) fibril formation.
Structural modeling of transmembrane (BRICHOS) domains of SFTPC precursor and BRI2/ITM2B (integral membrane protein 2B (show ITM2B ELISA Kits)) identifies conserved region structurally complementary to beta-sheet-/amyloid-prone regions in BRICHOS domain-containing proteins.
(surfactant protein C), a specific functional marker of human type II alveolar epithelial cells, was detected in differentiated cells by RT-PCR (reverse transcription-PCR) analysis after day 15.
The hydrophobic surfactant proteins SP-B and SP-C induce formation of bicontinuous inverse cubic phases.
a potential role for SP-C in generating small surfactant structures that may participate in cholesterol mobilization and pulmonary surfactant homeostasis at the alveolar interfaces
Data indicate that surfactant protein C (SP-C) structure does not seem altered by palmitoylation or the lipid environment.
Data suggest that transient exposure of surfactant to polymers like hyaluronan (HA) could be a promising strategy for the production of more efficient therapeutic surfactants SP-A (show SFTPA1 ELISA Kits), SP-B and SP-C preparations.
SP-B and SP-C proteins promote the formation of proteolipid channels in which lipid molecules are functionally involved.
Palmitoylation is key for the functional cooperation of SP-C with SP-B that enables cholesterol-containing surfactant films to reach very low tensions under compression.
Surfactant protein SP-B promoted film formation and reextension to lower surface tensions than SP-C.
finds evidence of an interaction between cholesterol-enriched phases and SP-C, and confirms that physiological concentrations of cholesterol do not have any detrimental effect on lung surfactant with a proper lipid and protein composition
study the effects of the interaction of SP-C with Dipalmitoleoylphosphatidylethanolamine on the adsorption and interfacial disintegration of phospholipid lamellar and non-lamellar phases and on the phase coexistence in insoluble DPoPE monomolecular films
This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.
surfactant protein C
, surfactant, pulmonary-associated protein C
, pulmonary surfactant-associated protein C
, pulmonary surfactant-associated proteolipid SPL(Val)
, BRICHOS domain containing 6
, pulmonary surfactant apoprotein-2 SP-C
, Surfactant pulmonary-associated protein C
, Surfactant, pulmonary-associated protein C
, surfactant associated protein C
, type I SP-C
, type II SP-C