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anti-Survival of Motor Neuron 1, Telomeric (SMN1) Antibodies

SMN1 is part of a 500 kb inverted duplication on chromosome 5q13. Additionally we are shipping SMN1 Kits (31) and SMN1 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMN1 20589  
SMN1 6606 Q16637
SMN1 64301 O35876
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Top anti-SMN1 Antibodies at antibodies-online.com

Showing 10 out of 104 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-SMN1 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 2 to 6 Days
$359.70
Details
Mouse Mouse Un-conjugated ICC, FACS, IF, IHC (p), IP, ELISA, WB Western blot showing Anti-SMN (gemin1) on HeLa cell extracts 50 μL Log in to see 5 to 6 Days
$402.29
Details
Human Mouse Un-conjugated FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of HepG2 cells using SMN1 mouse mAb (green) and negative control (purple) . 100 μL Log in to see 3 to 4 Days
$430.10
Details
Human Mouse Un-conjugated ICC, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Immunofluorescence analysis of HepG2 cells using SMN1 mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. 100 μL Log in to see 3 to 4 Days
$430.10
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 2 to 6 Days
$385.00
Details
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 21 to 31 Days
$237.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SMN1 AntibodyTitration: 1.0 µg/mL  Positive Control: Fetal Heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB SMN1 Antibody (C-term)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SMN1 antibody detected the SMN1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, WB WB Image Sample (30 ug of whole cell lysate) A: Hela 12% SDS PAGE antibody diluted at 1:1000 ICC/IF Image Immunofluorescence analysis of methanol-fixed HeLa, using SMN1, antibody at 1:200 dilution. 100 μL Log in to see 2 to 3 Days
$358.60
Details

SMN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SMN1 Antibodies

  1. Mouse (Murine) Monoclonal SMN1 Primary Antibody for ICC, FACS - ABIN108567 : Liu, Dreyfuss: A novel nuclear structure containing the survival of motor neurons protein. in The EMBO journal 1996 (PubMed)
    Show all 2 references for ABIN108567

  2. Human Polyclonal SMN1 Primary Antibody for IHC, ELISA - ABIN1585252 : Smith, Kuliszewski, Liao, Rudenko, Stewart, Leong-Poi: Sustained improvement in perfusion and flow reserve after temporally separated delivery of vascular endothelial growth factor and angiopoietin-1 plasmid deoxyribonucleic acid. in Journal of the American College of Cardiology 2012 (PubMed)

  3. Dog (Canine) Polyclonal SMN1 Primary Antibody for WB - ABIN2778671 : Hirano, Angelini, Montagna, Hays, Tanji, Mitsumoto, Gordon, Naini, DiMauro, Rowland: Amyotrophic lateral sclerosis with ragged-red fibers. in Archives of neurology 2008 (PubMed)

  4. Human Monoclonal SMN1 Primary Antibody for ICC, IHC - ABIN969408 : Hendrickson, Donohoe, Akmaev, Sugarman, Labrousse, Boguslavskiy, Flynn, Rohlfs, Walker, Allitto, Sears, Scholl: Differences in SMN1 allele frequencies among ethnic groups within North America. in Journal of medical genetics 2009 (PubMed)

  5. Human Monoclonal SMN1 Primary Antibody for IHC, ELISA - ABIN1585251 : Zhu, Guo, Yao, Yan, Xue, Hao, Zhou, Zhu, Qin, Lu: Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis: role of the AKT signaling pathway. in Oncogene 2014 (PubMed)

More Antibodies against SMN1 Interaction Partners

Cow (Bovine) Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. Data show that the coding sequence of survival of motor neuron 2 (SMN2) differs from that of survival motor neuron 1 (SMN1) by a single nucleotide (c.840C>T) at codon 280 in exon 7.

  2. SMN (show SNRPN Antibodies) protein functions in cytoplasmic Sm-core assembly and in the recruitment of the snRNA cap hypermethylase

Mouse (Murine) Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. muscle does not appear to require high levels of SMN (show STMN1 Antibodies) above what is produced by two copies of SMN2

  2. Findings demonstrate that high expression of SMN (show STMN1 Antibodies) in the motor neuron is both necessary and sufficient for proper function of the motor unit. In addition, SMN (show STMN1 Antibodies) high expression in neurons and glia has a major impact on survival.

  3. This study identifies pathways related to the function of Smn (show STMN1 Antibodies) and associated with differential motor unit vulnerability, thus presenting a number of exciting targets for future therapeutic development.

  4. Smn (show STMN1 Antibodies) complex deficiency caused constipation, delayed gastric emptying, slow intestinal transit and reduced colonic motility.

  5. Primary cell culture and two different SMA model mice to demonstrate that reduced levels of Smn (show STMN1 Antibodies) lead to a profound disruption in the expression of myogenic genes.

  6. Results suggest that SMN (show STMN1 Antibodies) plays a role in the maintenance of pluripotent embryonic stem cells and neuronal differentiation in mice.

  7. AAV9-mediated SMN (show STMN1 Antibodies) gene therapy elicits cure for spinal muscular atrophy.

  8. Data show that changes in U12 introns-dependent splicing become apparent after prolonged/extensive survival motor neuron proteins SMN (show STMN1 Antibodies) depletion.

  9. This work both reveals a new autoregulatory pathway governing SMN (show STMN1 Antibodies) expression, and identifies a new mechanism through which SMN (show STMN1 Antibodies) can modulate specific mRNA expression via Gemin5 (show GEMIN5 Antibodies).

  10. SMN (show STMN1 Antibodies) is involved in the axonal translocation of hnRNP R (show HNRNPR Antibodies) and hnRNP R (show HNRNPR Antibodies)-bound RNA/protein complexes.

Human Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. The results of this study show that, the plasmid containing UTR (show UTS2R Antibodies) elements causes to twice more SMN (show STMN1 Antibodies) gene expression in transfected cells.

  2. Data show that the coding sequence of survival of motor neuron 2 (SMN2) differs from that of survival motor neuron 1 (SMN1) by a single nucleotide (c.840C>T) at codon 280 in exon 7.

  3. The Cajal bodies fail to recruit SMN (show STMN1 Antibodies) and spliceosomal snRNPs, but contain the proteasome activator PA28, a molecular marker associated with the cellular stress response.

  4. PLS3 (show PLS3 Antibodies) is a genuine spinal muscular atrophy protective modifier in SMN1-deleted individuals

  5. Measurements of SMN (show STMN1 Antibodies) and PLS3 (show PLS3 Antibodies) transcript and protein levels in induced pluripotent stem cell-derived motor neurons show limited value as Spinal muscular atrophy biomarkers.

  6. The diverse a-SMN (show STMN1 Antibodies) vs FL-SMN (show STMN1 Antibodies) C-terminus may dictate different protein interactions and complex formation explaining the different localization and role in the neuronal compartment, and the lower expression and stability of a-SMN (show STMN1 Antibodies).

  7. SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control transcriptional termination

  8. Among 43 identified patients with spinal muscular atrophy, 37 (86.0%) showed homozygous deletion of SMN1 exon 7.

  9. Study detected 3 small mutations in 4 patients without homozygous deletion of the SMN1 gene, suggested that about 4% of spinal muscular atrophy patients have subtle mutations and might be considered in laboratory examination

  10. SMN1 Gene Point Mutations in Type I-IV Proximal Spinal Muscular Atrophy Patients with a Single Copy of SMN1

Pig (Porcine) Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. first cloning and identification of the swine SMN1 gene and show that there is significant sequence homology between swine and human SMN (show SNRPN Antibodies) throughout the coding region

SMN1 Antigen Profile

Protein Summary

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy\; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Two transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with SMN1

  • survival of motor neuron 1, telomeric (SMN1) antibody
  • immunoglobulin mu binding protein 2 (Ighmbp2) antibody
  • survival motor neuron 1 (Smn1) antibody
  • survival of motor neuron 1, telomeric (Smn1) antibody
  • survival of motor neuron 1, telomeric-like (LOC100348318) antibody
  • AEP antibody
  • AI849087 antibody
  • BCD541 antibody
  • Catf1 antibody
  • GEMIN1 antibody
  • nmd antibody
  • RIPE3b1 antibody
  • sma antibody
  • SMA1 antibody
  • SMA2 antibody
  • SMA3 antibody
  • SMA4 antibody
  • SMA@ antibody
  • Smbp-2 antibody
  • Smbp2 antibody
  • Smn antibody
  • SMN2 antibody
  • SMNT antibody
  • Smubp2 antibody
  • T-BCD541 antibody
  • TDRD16A antibody

Protein level used designations for SMN1

survival of motor neuron 2, centromeric , survival motor neuron protein , ATP-dependent helicase IGHMBP2 , DNA-binding protein SMUBP-2 , antifreeze enhancer-binding protein , cardiac transcription factor 1 , immunoglobulin S mu binding protein 2 , immunoglobulin mu-binding protein 2 , neuromuscular degeneration , p110 subunit , survival of motor neuron protein , component of gems 1 , gemin-1 , survival motor neuron 1 protein , tudor domain containing 16A , survival motor neuron 1

GENE ID SPECIES
461829 Pan troglodytes
677703 Macaca mulatta
100171813 Pongo abelii
100308165 Bos taurus
20589 Mus musculus
20595 Mus musculus
6606 Homo sapiens
100170853 Sus scrofa
64301 Rattus norvegicus
100713418 Cavia porcellus
281492 Bos taurus
101110178 Ovis aries
100348318 Oryctolagus cuniculus
Selected quality suppliers for anti-SMN1 (SMN1) Antibodies
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