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anti-Survival of Motor Neuron 2, Centromeric (SMN2) Antibodies

SMN2 is part of a 500 kb inverted duplication on chromosome 5q13. Additionally we are shipping Survival of Motor Neuron 2, Centromeric Kits (3) and Survival of Motor Neuron 2, Centromeric Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMN2 6607 Q16637
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Top anti-Survival of Motor Neuron 2, Centromeric Antibodies at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SMN2 AntibodyTitration: 1.0 µg/mL  Positive Control: Jurkat Whole Cell  SMN2 is supported by BioGPS gene expression data to be expressed in Jurkat 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IP Immunoprecipitation of SMN2 transfected lysate using anti-SMN2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with SMN2 purified MaxPab mouse polyclonal antibody (B01P) . 100 μL Log in to see 9 Days
$418.57
Details
Human Mouse Un-conjugated IF, WB SMN2 MaxPab polyclonal antibody. Western Blot analysis of SMN2 expression in human kidney. Western Blot analysis of SMN2 expression in transfected 293T cell line by SMN2 MaxPab polyclonal antibody.Lane 1: SMN2 transfected lysate(31.02 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37.55 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 14 Days
$369.79
Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged SMN2 is approximately 1ng/ml as a capture antibody. Western Blot analysis of SMN2 expression in transfected 293T cell line by SMN2 monoclonal antibody (M02), clone 1A3-2B9.Lane 1: SMN2 transfected lysate (Predicted MW: 31.8 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB SMN2 monoclonal antibody (M01), clone 2B11-2A9 Western Blot analysis of SMN2 expression in IMR-32 . SMN2 monoclonal antibody (M01), clone 2B11-2A9. Western Blot analysis of SMN2 expression in human colon. 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated ELISA, WB SMN2 polyclonal antibody (A01). Western Blot analysis of SMN2 expression in human ovarian cancer. Western Blot detection against Immunogen (57.13 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Mouse Un-conjugated WB Western Blot analysis of SMN2 expression in transfected 293T cell line by SMN2 MaxPab polyclonal antibody.Lane 1: SMN2 transfected lysate(32.34 KDa).Lane 2: Non-transfected lysate. 50 μg Log in to see 9 Days
$430.00
Details

SMN2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human ,
,
,

More Antibodies against Survival of Motor Neuron 2, Centromeric Interaction Partners

Human Survival of Motor Neuron 2, Centromeric (SMN2) interaction partners

  1. Thus, we can conclude that SMN2 (show SMN1 Antibodies) methylation may regulate the SMA (show SMN1 Antibodies) disease phenotype by modulating its transcription.

  2. This study demonstrated that Deficiency of the Survival of SMN2 (show SMN1 Antibodies) Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons

  3. Inverse correlation was observed between SMN2 (show SMN1 Antibodies), SERF1A and NAIP (show NAIP Antibodies) copy number polymorphism and spinal muscular atrophy type.

  4. Loss of SMN2 (show SMN1 Antibodies) expression is associated with Spinal muscular atrophy.

  5. Depletion of two of the most potent inhibitors of SMP2 (show LPIN3 Antibodies) exon 7 inclusion, SRSF2 (show SRSF2 Antibodies) or SRSF3 (show SRSF3 Antibodies), in cell lines derived from SMA (show SMN1 Antibodies) patients, increased SMN2 (show SMN1 Antibodies) exon 7 inclusion and SMN (show STMN1 Antibodies) protein level.

  6. Smn (show STMN1 Antibodies) complex deficiency caused constipation, delayed gastric emptying, slow intestinal transit and reduced colonic motility.

  7. results indicate that high expression level of Tra2-beta1 is responsible for increased SMN2 (show SMN1 Antibodies) exon 7 inclusion in the testis of SMA (show SMN1 Antibodies) mice.

  8. Missense point mutations in the C-terminal domain of SMN2 leads to loss of small nuclear ribonucleoprotein assembly.

  9. In the Serbian patients with spinal muscular atrophy, a higher SMN2 (show SMN1 Antibodies) gene copy number correlated with less severe disease phenotype.

  10. The copy numbers and gene structures of SMN2 (show SMN1 Antibodies) genes were different in Chinese spinal muscular atrophy patients and healthy controls.

Survival of Motor Neuron 2, Centromeric (SMN2) Antigen Profile

Protein Summary

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. This gene may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with SMN2

  • survival of motor neuron 2, centromeric (SMN2) antibody
  • survival of motor neuron 1, telomeric (SMN1) antibody
  • BCD541 antibody
  • C-BCD541 antibody
  • GEMIN1 antibody
  • SMN2 antibody
  • SMNC antibody
  • TDRD16B antibody

Protein level used designations for SMN2

component of gems 1 , gemin-1 , survival motor neuron protein , tudor domain containing 16B , survival of motor neuron 2, centromeric

GENE ID SPECIES
6607 Homo sapiens
461829 Pan troglodytes
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