Symplekin Proteins (SYMPK)

SYMPK encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. Additionally we are shipping Symplekin Antibodies (52) and Symplekin Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SYMPK 8189 Q92797
Rat SYMPK SYMPK 292683  
SYMPK 68188  
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Top Symplekin Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days

SYMPK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

More Proteins for Symplekin (SYMPK) Interaction Partners

Fruit Fly (Drosophila melanogaster) Symplekin (SYMPK) interaction partners

  1. Authors propose a model in which the core cleavage complex formation is mediated by CPSF73 (show CPSF3 Proteins), CPSF100 (show CPSF2 Proteins), and Symplekin C-termini, and the N-terminal region of Symplekin facilitates cotranscriptional 3' end processing of histone mRNAs.

  2. This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 (show CPSF3 Proteins) and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions.

  3. Together, these data support the conclusion that the Symplekin HEAT domain serves as a scaffold for protein-protein interactions essential to the mRNA maturation process.

Arabidopsis thaliana Symplekin (SYMPK) interaction partners

Human Symplekin (SYMPK) interaction partners

  1. Data indicate rs56848936 in the gene symplekin protein (SYMPK) at 19q13.3, associated with colon cancer risk.

  2. CPSF2 (show CPSF2 Proteins) and SYMPK, are RBFOX2 (show RBM9 Proteins) cofactors for both inclusion and exclusion of internal exons.

  3. Symplekin interacts and co-localizes with both MOZ and MLL (show MLL Proteins) in immature hematopoietic cells. Its inhibition leads to a decrease of the HOXA9 (show HOXA9 Proteins) protein level but not of Hoxa9 (show HOXA9 Proteins) mRNA.

  4. Symplekin expression regulates the assembly of tight junctions, thus helps to maintain the integrity of the epithelial monolayer and cellular polarity.

  5. crystal structure at 2.4 A resolution of the amino-terminal domain (residues 30-340) of human symplekin in a ternary complex with the Pol II carboxy-terminal domain (CTD) Ser (show SIGLEC1 Proteins) 5 phosphatase Ssu72 (show SSU72 Proteins) and a CTD Ser (show SIGLEC1 Proteins) 5 phosphopeptide

  6. Symplekin supports faithful mitosis by contributing to the formation of a bipolar spindle apparatus. Depletion of symplekin attenuates microtubule polymerization as well as expression of the critical microtubule polymerization protein CKAP5 (TOGp).

  7. Data show that claudin-2 (show CLDN2 Proteins) expression was reduced following symplekin down-regulation, and siRNA-mediated claudin-2 (show CLDN2 Proteins) down-regulation increased the transepithelial resistance and decreased cyclin D1 (show CCND1 Proteins) expression and ZONAB (show CSDA Proteins) nuclear localization.

  8. symplekin has a role in HSF1 (show HSF1 Proteins) modulation of Hsp70 (show HSP70 Proteins) mRNA polyadenylation

  9. The decreased expression of symplekin may be an early step in the transformation of hepatocytes, whereas alteration of the expression of adherens junctions and desmosomes may indicate more serious changes.

  10. The symplekin/ZONAB (show CSDA Proteins) complex inhibits intestinal cell differentiation by the repression of AML1/Runx1 (show RUNX1 Proteins).

Xenopus laevis Symplekin (SYMPK) interaction partners

  1. Here, we identify a new factor essential for polyadenylation, namely, symplekin, a CPEB and CPSF (show CPSF2 Proteins) binding protein that serves as a scaffold upon which regulatory factors are assembled

Symplekin (SYMPK) Protein Profile

Protein Summary

This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.

Gene names and symbols associated with Symplekin Proteins (SYMPK)

  • Symplekin (Sym)
  • symplekin (sympk)
  • symplekin (SYMPK)
  • Symplekin/Pta1-like protein (ESP4)
  • symplekin tight junction protein domain-containing protein (AT1G27595)
  • symplekin (AaeL_AAEL002437)
  • symplekin (CpipJ_CPIJ011126)
  • Symplekin (Bm1_50390)
  • symplekin (NAEGRDRAFT_80124)
  • symplekin (LOAG_00841)
  • symplekin (LOC100348044)
  • symplekin (Sympk)
  • 1500016F02Rik protein
  • 4632415H16Rik protein
  • AA125406 protein
  • AI449890 protein
  • CG2097 protein
  • DKFZp468C0711 protein
  • Dmel\\CG2097 protein
  • dSymp protein
  • Hfn3g protein
  • MGC75595 protein
  • SPK protein
  • SYM protein
  • SYMPK protein
  • T10O8.110 protein
  • T10O8_110 protein
  • T22C5.3 protein

Protein level used designations for Symplekin Proteins (SYMPK)

CG2097-PA , Sym-PA , symplekin , Symplekin , symplekin-like , hepatocyte nuclear factor 3 gamma

40709 Drosophila melanogaster
394872 Xenopus (Silurana) tropicalis
456142 Pan troglodytes
476431 Canis lupus familiaris
552752 Apis mellifera
831597 Arabidopsis thaliana
839651 Arabidopsis thaliana
5580150 Aedes aegypti
6043768 Culex quinquefasciatus
6104963 Brugia malayi
8853240 Naegleria gruberi strain NEG-M
9938210 Loa loa
100010885 Monodelphis domestica
100070949 Equus caballus
100174376 Pongo abelii
100179022 Ciona intestinalis
100348044 Oryctolagus cuniculus
100412467 Callithrix jacchus
100474335 Ailuropoda melanoleuca
100512609 Sus scrofa
8189 Homo sapiens
292683 Rattus norvegicus
100337373 Bos taurus
68188 Mus musculus
379378 Xenopus laevis
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