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SYN1 is a member of the synapsin gene family. Additionally we are shipping Synapsin I Antibodies (292) and Synapsin I Kits (24) and many more products for this protein.
Showing 9 out of 10 products:
Patterns of the immunoreactivity with antibodies to SNAP-25 (show SNAP25 Proteins), synapsin-I and synaptophysin (show SYP Proteins) are completely appropriate to those of adult's OB on the 38-40 weeks of the prenatal development.
The implementation of the AlphaScreen pSYN1 assay and future development of additional primary neuronal HTS (show APCDD1 Proteins) assays provides an attractive approach for discovery of novel classes of therapeutic candidates for a variety of CNS disorders.
these findings suggest PRICKLE1 (show PRICKLE1 Proteins) mutations contribute to ASD (show ARSD Proteins) by disrupting the interaction with SYN1 and regulation of synaptic vesicles.
Data indicate that in patients carrying the W356x mutation the function of synapsin I is markedly impaired, and support the value of Syn1(-/-) mice as an experimental model mimicking the human pathology.
Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity.
The histone modification marks were significantly increased in major depression and this effect was correlated with significant increases in SYN1b gene expression.
A conserved region of human and mouse SYN1 promoters contains cis (show CISH Proteins)-sites for the transcriptional activator Sp1 (show PSG1 Proteins) in close proximity to REST binding motifs.
The allelic frequencies of SYN1 are associated with Korean female schizophrenia.
SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function.
the nucleocytoplasmic shuttling of dysbindin-1 (show DTNBP1 Proteins) regulates synapsin I expression and thus may be involved in the pathogenesis of schizophrenia.
Synapsin I is localized and produced at mature axon terminals and at immature growth cones.
HSV-1-infected neurons also exhibite significantly reduced expression of the presynaptic proteins synapsin-1 and synaptophysin. These effects depended on GSK-3 activation and intraneuronal accumulation of Ab
Functions of synapsins in corticothalamic facilitation: important roles of synapsin I
SynI mRNA and protein levels are down-regulated in the hippocampus of naive and Morris water maze-treated En2 (show EN2 Proteins)-/- mice.
these findings suggest PRICKLE1 (show PRICKLE1 Proteins) mutations contribute to ASD (show GUSB Proteins) by disrupting the interaction with SYN1 and regulation of synaptic vesicles.
during chronic modification of neuronal activity and is an essential downstream effector for the Cdk5 (show CDK5 Proteins)-mediated homeostatic scaling.
O-GlcNAcylation of Thr (show TRH Proteins)-87 interferes with folding of the ALPS motif, providing a means for regulating the association of synapsin I with SVs (show FGFR2 Proteins) as a mechanism contributing to synapsin I localization and RPSV generation.
This study demonstrated a seizure-inducing potential of regular handling in both Syn1KO and Syn2KO mice during a period between P21 and 4 1/2 months of age.
These results raise the possibility that Ser (show SIGLEC1 Proteins)(603) on synapsin I is alternatively phosphorylated by p21 (show CDKN1A Proteins)-activated kinases, not only by CaMKII (show CAMK2G Proteins), in neuronal cells in response to some stimulants.
Synapsin-Rab3 (show RAB3A Proteins) interaction may participate in the regulation of synaptic vesicle trafficking within the nerve terminals.
Interacts with rab3 (show RAB3A Proteins) protein; this interaction is likely to play a major role in the modulation of neurotransmitter release.
This study reports molecular cloning and characterization of the coding sequence of the porcine ortholog of syn (show SYNM Proteins) I, including identification and verification at the protein level of an alanine-encoding insert.
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
, synapsin 1
, brain protein 4.1