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SYN2 is a member of the synapsin gene family. Additionally we are shipping Synapsin II Proteins (4) and Synapsin II Kits (1) and many more products for this protein.
Showing 10 out of 34 products:
Rat (Rattus) Polyclonal SYN2 Primary Antibody for IHC, WB - ABIN350889
Jaffrey, Benfenati, Snowman, Czernik, Snyder: Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 2 references for ABIN350889
Human Polyclonal SYN2 Primary Antibody for ICC, IP - ABIN1742208
Chen, Yu, Huang, Yu, Zhu, Lam, Lam, Zhou: Prenatal transfer of polybrominated diphenyl ethers (PBDEs) results in developmental neurotoxicity in zebrafish larvae. in Environmental science & technology 2012
Show all 2 references for ABIN1742208
Rat (Rattus) Polyclonal SYN2 Primary Antibody for IHC, WB - ABIN350890
Suedhof, Lottspeich, Greengard, Mehl, Jahn: A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions. in Science (New York, N.Y.) 1987
Show all 2 references for ABIN350890
Human Monoclonal SYN2 Primary Antibody for ICC, WB - ABIN1742207
Acuna, Liu, Südhof: How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs. in Neuron 2016
Mouse (Murine) Polyclonal SYN2 Primary Antibody for IP, WB - ABIN266022
Jovasevic, Corcoran, Leaderbrand, Yamawaki, Guedea, Chen, Shepherd, Radulovic: GABAergic mechanisms regulated by miR-33 encode state-dependent fear. in Nature neuroscience 2015
These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2, in mood disorders and improve our understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype.
Both GABRA6 (show GABRA6 Antibodies) and Synapsin II polymorphisms are important risk factors for the development of idiopathic generalized epilepsy in a South Indian population.
Results identify SYN2 as a novel predisposing gene for autism spectrum disorders (ASD (show ARSD Antibodies)) and strengthen the hypothesis that a disturbance of synaptic homeostasis underlies ASD (show ARSD Antibodies).
Synapsin II is involved in the molecular pathway of lithium treatment in bipolar disorder
SYN2 rs3773364 A>G polymorphism is not a risk factor for susceptibility to epilepsy in this case-control study and meta-analysis.
Results from our study indicate the involvement of SYN2 gene polymorphism in conferring risk to epilepsy; however, the genetic variant does not seem to modulate drug-response in epilepsy pharmacotherapy.
This study suggests a positive association between synapsin II and schizophrenia, implying that synapsin II is involved in the etiology of schizophrenia.
synapsin II variants are associated with susceptibility to schizophrenia.
Syn2 is likely to be involved in the etiology or pathogenesis of schizophrenia.
A case-control study with synapsin II was conducted in 506 bipolar disorder patients and 507 healthy individuals from the Han Chinese population. No association was found in this study.
Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 (show FFAR3 Antibodies) linking to Gbetagamma-PLCbeta3-ERK1/2 (show MAPK1/3 Antibodies)-synapsin 2
Deletion of synapsin II, a presynaptic protein contributing to epilepsy predisposition in humans, leads to a loss of tonic inhibition in mouse hippocampal slices due to a dramatic decrease in presynaptic asynchronous GABA release.
In synapsin II(-) hippocampal neurons an overexcitable phenotype was observed.
This study demonstrated a seizure-inducing potential of regular handling in both Syn1KO and Syn2KO mice during a period between P21 (show D4S234E Antibodies) and 4 1/2 months of age.
Behavioral and neurophysiological features of Syn-2 (show STX2 Antibodies) knockout mice are characterized by observation of the development and progress of seizures from postnatal day 20 to 180.
The histone modification marks were significantly increased in bipolar disorder and major depression and this effect was correlated with significant increases in syn2 gene expression.
Syn (show SYP Antibodies) II promotes gamma-aminobutyric acid asynchronous release in a Ca(2 (show CA2 Antibodies)+)-dependent manner.
Analysis of cultured neurons from wild-type and Syn (show SYP Antibodies) I,II,III-deficient triple knock-out (TKO (show MRPS12 Antibodies)) mice shows that synaptic vesicles are severely dispersed in the absence of Syns.
We conclude that neither synapsin I (show SYN1 Antibodies) nor synapsin II are directly involved in the regulation of glucose-stimulated insulin (show INS Antibodies) secretion and Ca(2 (show CA2 Antibodies))-dependent exocytosis in mouse pancreatic beta-cells.
Synapsin I (show SYN1 Antibodies) and II affect distinct excitatory glutamatergic synapses in the hippocampus, synapsin-dependent modulations of synaptic function may use distinct presynaptic response patterns to induce different classes of presynaptic plasticity.[Review]
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. The TIMP4 gene is located within an intron of this gene and is transcribed in the opposite direction. Mutations in this gene may be associated with abnormal presynaptic function and schizophrenia. Alternative splicing of this gene results in two transcripts.
, synapsin IIa
, synapsin 2