You are viewing an incomplete version of our website. Please click to reload the website as full version.

Synaptic Ras GTPase Activating Protein 1 Proteins (SYNGAP1)

The protein encoded by SYNGAP1 is a major component of the postsynaptic density (PSD), a group of proteins found associated with NMDA receptors at synapses. Additionally we are shipping SYNGAP1 Antibodies (57) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SYNGAP1 SYNGAP1 192117  
SYNGAP1 8831 Q96PV0
SYNGAP1 240057 F6SEU4
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top SYNGAP1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SYNGAP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) Interaction Partners

Human Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) interaction partners

  1. De novo, heterozygous, loss-of-function mutations in SYNGAP1 cause a syndromic form of intellectual disability.

  2. This is the first description of a special electroencephalogram phenomenon (normalization with eye opening) in association with SYNGAP1 mutations.

  3. Syngap transgenic mice exhibited alterations in long-term depression and dendritic spine morphology.

  4. Phosphorylation of synaptic GTPase-activating protein (show RASA1 Proteins) (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5 (show CDK5 Proteins)) alters the ratio of its GAP activity toward Ras and Rap (show LRPAP1 Proteins) GTPases.

  5. Reduced cognition in mutant Syngap1 transgenic mice is caused by isolated damage to developing forebrain neurons.

  6. De novo CHD2 and SYNGAP1 mutations are new causes of epileptic encephalopathies, accounting for 1.2% and 1% of cases, respectively.

  7. De novo missense mutations, p.R579X, and possibly all the other truncating mutations in SYNGAP1 result in a loss of its function, causing intellectual disability, autism, and a specific form of epilepsy.

  8. SYNGAP1 is a brain-specific protein (show TPPP3 Proteins) that interacts with key components of the proteins involved in experience-dependent changes in glutamate (show GRIN1 Proteins) synapses involved in learning.

  9. We provide evidence that truncating mutations in SYNGAP1 are common in nonsyndromic intellectual disability and can be also associated with autism.

  10. The C2 domain of SynGAP is essential for stimulation of the Rap (show LRPAP1 Proteins) GTPase (show RACGAP1 Proteins) reaction.

Mouse (Murine) Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) interaction partners

  1. Study found that Syngap1 mutations associated with developmental brain disorders disrupt a critical period of neuronal growth, maturation, and dynamics of dendritic structures known to influence de novo assembly of developing cortical circuits

  2. Phosphorylation of synaptic GTPase-activating protein (show RASA1 Proteins) (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5 (show CDK5 Proteins)) alters the ratio of its GAP activity toward Ras and Rap (show LRPAP1 Proteins) GTPases.

  3. inactivation of a single copy of syngap1 induced widespread early functional maturation of excitatory connections in the mouse neocortex

  4. These data demonstrate that SynGAP protein acts as a critical developmental repressor of neural excitability that promotes the development of life-long cognitive abilities.

  5. This study demonstrated the functional significance of SynGAP1 signaling in the adult brain by capturing several changes that are dependent on NMDAR (show GRIN1 Proteins) and hippocampal integrity.

  6. Overexpression of SynGAP alpha1 versus alpha2 C-termini-containing proteins in hippocampal neurons has opposing effects on synaptic strength, decreasing and increasing miniature excitatory synaptic currents amplitude/frequency, respectively.

  7. SynGAP is an important regulator of the release of the neuropeptide calcitonin gene-related peptide (show CALCA Proteins) from primary sensory neurons and can modulate capsaicin-induced hypernociception.

  8. Data show that deletion of SynGAP is associated with notable behavioral as well as morphological phenotypes indicative of hippocampal dysfunction.

  9. The GAP activity of synGAP and its association with PSD-95 (show DLG4 Proteins) are important for normal regulation of spine and synapse formation in hippocampal neurons.

  10. SynGAP expression peaked at times of synaptogenesis and developmental plasticity and SynGAP showed a more spatially restricted pattern as illustrated by its restriction to forebrain

SYNGAP1 Protein Profile

Protein Summary

The protein encoded by this gene is a major component of the postsynaptic density (PSD), a group of proteins found associated with NMDA receptors at synapses. The encoded protein is phosphorylated by calmodulin-dependent protein kinase II and dephosphorylated by NMDA receptor activation. Defects in this gene are a cause of mental retardation autosomal dominant type 5 (MRD5).

Gene names and symbols associated with SYNGAP1

  • synaptic Ras GTPase activating protein 1 (SYNGAP1)
  • synaptic Ras GTPase activating protein 1 (LOC100352163)
  • synaptic Ras GTPase activating protein 1 (syngap1)
  • synaptic Ras GTPase activating protein 1 (Syngap1)
  • synaptic Ras GTPase activating protein 1 homolog (rat) (Syngap1)
  • Gm1963 protein
  • MRD5 protein
  • RASA1 protein
  • RASA5 protein
  • SYNGAP protein
  • SYNGAP1 protein

Protein level used designations for SYNGAP1

synaptic Ras GTPase activating protein 1 , neuronal RasGAP , p135 SynGAP , ras GTPase-activating protein SynGAP , ras/Rap GTPase-activating protein SynGAP , synaptic Ras GTPase-activating protein 1 , synaptic Ras-GAP 1 , Ras GTPase-activating protein SynGAP , synaptic Ras GTPase activating protein 1 homolog , synaptic Ras GTPase activating protein, 135kDa

GENE ID SPECIES
717858 Macaca mulatta
746276 Pan troglodytes
100147004 Equus caballus
100352163 Oryctolagus cuniculus
100558580 Anolis carolinensis
192117 Rattus norvegicus
8831 Homo sapiens
481742 Canis lupus familiaris
100525524 Sus scrofa
790307 Bos taurus
240057 Mus musculus
Selected quality suppliers for SYNGAP1 Proteins (SYNGAP1)
Did you look for something else?