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a synaptic vesicle protein; conserved between vertebrates and invertebrates. Additionally we are shipping SV2C Antibodies (37) and and many more products for this protein.
N-linked glycosylation of SV2C is required for binding and uptake of botulinum neurotoxin A.
Studies indicate that botulinum neurotoxins (BoNTs) in complex with its protein receptor, synaptic vesicle glycoprotein 2 (SV2 (show SV2A ELISA Kits)) family member C represented a major advance for the detailed molecular understanding of BoNT-host cell receptor interactions.
A genetic variant in SV2C predicted clinically relevant bevacizumab-induced hypertension in two independent, randomised phase III trials.
In classical mesial temporal sclerosis 1A, the expression of SV2 (show SV2A ELISA Kits) isoforms is altered with a selective increase of SV2C in sprouting mossy fibres.
The fact that multiple SNPs in SV2C may impact response to atypical antipsychotics suggests that further evaluation of SNPs in this gene
high-resolution crystal structure of the BoNT/A receptor-binding domain in complex with the SV2C luminal domain
Results showed that SV2C, a poorly functionally characterized protein is strongly involved in normal operation of the basal ganglia network and could be also involved in system adaptation in basal ganglia pathological conditions.
SV2C protein was expressed in a small subset of brain regions including the olfactory bulb, olfactory tubercle, nucleus accumbens, caudate-putamen, ventral pallidum, globus pallidus, substantia nigra and the ventral tegmental area.
findings show that botulinum neurotoxin (BoNT/A) enters neurons by binding to the synaptic vesicle protein SV2 (show SV2A ELISA Kits) (isoforms A, B, and C);SV2 (show SV2A ELISA Kits) acts as the protein receptor for BoNT/A
Botulinum neurotoxin A also interacts with a synaptic vesicle protein, the synaptic vesicle glycoprotein 2C (SV2C), but not with the homologous proteins SV2A (show SV2A ELISA Kits) and SV2B (show SV2B ELISA Kits).
a synaptic vesicle protein; conserved between vertebrates and invertebrates
synaptic vesicle glycoprotein 2C
, synaptic vesicle protein 2C