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Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Additionally we are shipping SYCE1 Antibodies (10) and many more products for this protein.
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A mutation in SYCE1 is associated with non-obstructive azoospermia.
Given the known function of the SYCE1 gene, we suggest that the nonsense mutation identified accounts for the primary ovarian insufficiency phenotype.
Genes involved in essential steps in chromosome synapsis and recombination during meiosis, such as synaptonemal complex central element 1 (SYCE1), have been shown to cause POI in animal models.
The localisation of Syce1 and Cesc1 (Syce2 (show SYCE2 Proteins)) to the central element depends on recruitment by Sycp1 (show SYCP1 Proteins).
Mutation in the Syce1 results in disruption of synapsis.
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).
synaptonemal complex central element protein 1
, cancer/testis antigen 76
, telomeric protein