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Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Additionally we are shipping SYCP1 Antibodies (77) and SYCP1 Proteins (3) and many more products for this protein.
Data from male/female transgenic zebrafish suggest proximal promoter fragment coupled to first exon/first intron of sycp1 gene contains information required for cell-specific expression of sycp1 in spermatocytes/spermatids and early primary oocytes.
Golli-BG21 enhanced SCP1/GIP phosphatase activity, whereas PKCalpha (show PKCa ELISA Kits)-phosphorylated BG21 inhibited its activity, suggesting a potential role of BG21 as a molecular switch ("quick-brake mechanism") on SCP1/GIP.
PLK1, but not PLK2-4, phosphorylates central element proteins SYCP1 and TEX12.
SYCP1 and SYCP3 (show SYCP3 ELISA Kits) act at the centromeres to promote the establishment and/or maintenance of centromere pairing and, by doing so, improve the segregation fidelity of mammalian meiotic chromosomes.
Findings suggest that SCP1 (show CRISP1 ELISA Kits) may inhibit the osteoblastic differentiation induced by the BMP-Smad (show SMAD1 ELISA Kits) axis via Runx2 (show RUNX2 ELISA Kits) by suppressing downstream effector(s).
SYCP1 has a coordinating role, and ensures formation of crossovers
The localisation of Syce1 (show SYCE1 ELISA Kits) and Cesc1 (Syce2 (show SYCE2 ELISA Kits)) to the central element depends on recruitment by Sycp1.
Crystal structure of C-terminal coiled-coil domain of SYCP1 reveals non-canonical anti-parallel dimeric structure of transverse filament at the synaptonemal complex.
crystal structure of the middle part of the human synaptonemal complex protein 1 coiled-coil domain
SYCP1, cTAGE1, and GTSF1 are expressed in cutaneous T-cell lymphoma, but not in normal skin or benign inflammatory dermatoses.
Cancer-Testis Antigen SCP-1 mRNA is expressed in some nasopharyngeal carcinoma.
an epitope derived from the cancer testis antigen HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4 (show CD4 ELISA Kits)+ T cells
Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
synaptonemal complex protein 1
, synaptonemal complex protein 1-like
, NLI-interacting factor 3
, carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
, golli-interacting protein
, nuclear LIM interactor-interacting factor 3
, small C-terminal domain phosphatase 1
, small CTD phosphatase 1
, cancer/testis antigen 8
, A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes
, Meiotic chromosome synaptic protein