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SYCP3 encodes an essential structural component of the synaptonemal complex. Additionally we are shipping SYCP3 Antibodies (83) and SYCP3 Kits (3) and many more products for this protein.
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Immunohistochemical observations revealed that Sycp3 is specifically localized in spermatocytes in typical nuclear patterns at each meiotic stage.
SYCP1 (show SYCP1 Proteins) and SYCP3 act at the centromeres to promote the establishment and/or maintenance of centromere pairing and, by doing so, improve the segregation fidelity of mammalian meiotic chromosomes.
Unlike other vertebrates, rat and mouse SYCP3 exists in 2 isoforms; the short isoform is conserved in vertebrates and the longer isoform, appeared 15 million years ago in a common ancestor of rat and mouse and after separation from the hamster branch.
X-linked lymphocyte-regulated protein pM1 (XMR), XLR, and SCP3 render tumor cells resistant to antitumor immunity
absence of synaptonemal complex protein 3 (SCP3) promotes aneuploidy in murine oocytes by inducing defective meiotic chromosome segregation
In Scp3-deficient (knockout) mice, spermatogenesis and testicular degeneration are augmented when E2F1 (show E2F1 Proteins) is also deficient.
Rad21 (show RAD21 Proteins), and the superimposed SCP3 and SCP2 (show CRISP3 Proteins), are involved in the monopolar attachment of sister kinetochores during meiosis I
SYCP2 and SYCP3 proteins function in the specificity of chromatin attachment to the chromosome core
SYCP3 has a temporally restricted role in maintaining, but not establishing, cohesin-core organization during prophase I.
The SYCP3 is expressed in germ cell-like cells. The nuclear distribution of SYCP3 in the germ cell-like cells is highly abnormal and not associated with the chromosomes of these cells.
DNA double-stranded breaks are inefficiently repaired in Sycp3(-)(/)(-) oocytes, thereby generating a temporal spectrum of recombination errors. T
SYCP3 binding and assembly on meiotic chromosomes leads to their organisation into compact structures compatible with recombination and crossover formation
The T657C polymorphism of the SYCP3 gene is possibly associated with recurrent pregnancy loss of unknown cause in human.
SCP3 (show CTDSPL Proteins) plays an important role in the progression of cervical cancer
SYCP3 mutations are not associated with the genetic susceptibility for meiotic arrest in infertile male patients with nonobstructive azoospermia in the Turkish population
screening for genetic variants in AURKB (show AURKB Proteins) and SYCP3 among these patients with reproductive problems using Sanger sequencing. Only one apparently non-pathogenic deletion was found in SYCP3.
Positive synaptonemal complex protein 3 expression is a portent of poor outcome and may be a potential biomarker in the early stages of the non-small cell lung cancer for survival.
mutations in SYCP3 do not contribute significantly to risk for recurrent miscarriage through maternal meiotic nondisjunction.
Expression of SYCP3 inhibits the homologous recombination (HR) pathway mediated by RAD51 (show RAD51 Proteins).
The 657T>C mutation of SYCP3 may not be associated with recurrent miscarriage caused by aneuploidy.
mutation analysis of SYCP3, DNMT3L (show TRDMT1 Proteins) and MSH4 (show MSH4 Proteins) in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages; heterozygous change, detected in a conserved functional domain of the SYCP3 gene, was absent in >200 controls
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein.
, diacylglycerol cholinephosphotransferase 1
, synaptonemal complex protein 3
, synaptonemal complex protein 3-like
, Meiotic chromosome core protein
, Synaptonemal complex protein COR1