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Has an actin-binding and actin-bundling activity (By similarity).. Additionally we are shipping Synaptopodin 2 Kits (8) and and many more products for this protein.
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Human Polyclonal SYNPO2 Primary Antibody for EIA, WB - ABIN783775
Schroeter, Beall, Heid, Chalovich: In vitro characterization of native mammalian smooth-muscle protein synaptopodin 2. in Bioscience reports 2008
Show all 2 references for ABIN783775
Data suggest that fesselin stabilizes myosin filaments and tethers myosin to actin; the rate of dissociation of myosin filaments (but not heavy meromyosin) from actin is greatly reduced by fesselin.
High Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration.
Promoter hypermethylation and down regulation of SYNPO2 has significance in the prognosis of melanoma patients.
myopodin is epigenetically modified in colon cancer
the N-terminus of myopodin binds integrin-linked kinase (ILK (show ILK Antibodies)) both in vivo and in vitro
myopodin functions as a tumor suppressor gene to limit the growth and to inhibit the metastasis of cancer cells
Imp13 (show IPO13 Antibodies) functions in myopodin import and the regulation of this event is critical for normal and abnormal cellular differentiation.
The myopodin new isoform (Myo2), in addition to the two predicted isoforms (Myo1 (show DNAH8 Antibodies) and Myo3), are transcribed in various mammalian tumor cell lines.
The subcellular localization of myopodin is involved in its suppressor or activator function in tumorigenesis.
The identification of myopodin as a direct target of PKA, CaMKII (show CAMK2G Antibodies), and calcineurin (show PPP3CA Antibodies) defines a novel intracellular signaling pathway whereby changes in Z-disc dynamics may translate into compartmentalized signal transduction in the heart.
Has an actin-binding and actin-bundling activity (By similarity).
, Synaptopodin 2-like
, genethonin 2