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May play a role in vesicle trafficking (By similarity). Additionally we are shipping Synaptotagmin Like Protein 1 Antibodies (32) and many more products for this protein.
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results reveal that MEIS1 (show MEIS1 Proteins), through induction of SYTL1, promotes leukemogenesis and supports leukemic cell homing and engraftment, facilitating interactions between leukemic cells and bone marrow stroma.
High Expression of secretory leukocyte protease inhibitor (show SLPI Proteins) is associated with metastasis in colorectal cancer.
SLPI (show SLPI Proteins) regulation and activity is altered in the nasal mucosa of smokers.
Cdk2 (show CDK2 Proteins) also binds the N-terminal domain of Fbw7 (show FBXW7 Proteins)-gamma as well as SLP-1.
during exocytosis, actin depolymerization commences near the secretory organelle, not the plasma membrane, and secretory granules use a JFC1- and GMIP-dependent molecular mechanism to traverse cortical actin.
transcriptional activation of JFC1 by the TNFalpha (show TNF Proteins)/NF-kappaB (show NFKB1 Proteins) pathway is significant in prostate carcinoma cell lines
evidence that JFC1 differentially regulates the secretion of PSAP and PSA, and that Rab27a and PI3K play a central role in the exocytosis of prostate-specific markers
Levels of mRNA and immunostaining of the antiproteases elafin (show PI3 Proteins) and SLPI (show SLPI Proteins) were enhanced strongly in inflamed versus noninflamed UC. Elafin (show PI3 Proteins) and SLPI (show SLPI Proteins) may be added to the list of defensin (show DEF Proteins)-like peptides with diminished induction in CD versus UC.
These results suggest that both Slp1 and Slp2-a (show SYTL2 Proteins) may form part of a docking complex, capturing secretory lysosomes at the immunological synapse.
Slp1 inhibits dense granule secretion in platelets and that Rap1GAP2 (show RAP1GAP2 Proteins) modulates secretion by binding to Slp1.
Granuphilin (show SYTL4 Proteins) and exophilin7, differentially regulate the exocytosis of either stably or minimally docked granules, respectively.
Expression of Rab27B (show RAB27B Proteins)-binding proteinm Sytl1 (show SYT1 Proteins) in pancreatic acinar cells and its involvement in amylase (show AMY Proteins) secretion are reported.
Jfc1/synaptotagmin-like protein 1 (Slp1) contains an N-terminal Slp (show SEPT9 Proteins) homology domain (SHD (show SHD Proteins)) (PMID: 11327731). The SHD (show SHD Proteins) of Slp1/Jfc1 specifically and directly binds the GTP (show AK3 Proteins)-bound form of Rab27A (show RAB27A Proteins) (J. Biol. Chem. 277, (2002) 9212-9218; PMID: 11773082).
May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).
NADPH oxidase-related, C2 domain-containing protein
, synaptotagmin-like protein 1