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SYT7 is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Additionally we are shipping Synaptotagmin VII Antibodies (74) and Synaptotagmin VII Proteins (5) and many more products for this protein.
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the results suggest that the two C2 domains of Syt7 bind independently to planar membranes, in contrast to reported interdomain cooperativity in Syt1 (show SYT1 ELISA Kits)
The membrane dissociation of SYT7 C2A domain but not SYT1 C2A domain is slowed by Na(2)SO(4) and trehalose, solutes that enhance the hydrophobic effect.
identified the conserved alternative splicing events in the spacer domain of Syt VII; also shown that Syt (show SS18 ELISA Kits) VIIa-GFP is mainly localized in the perinuclear region and tips of neurites (dense-core vesicles), and not in the plasma membrane
Data (including data from studies in knockout mice) suggest that loss of both Syt1 (show SYT1 ELISA Kits)/Syt7 decreases capacity of readily-releasable pool (RRP (show RRBP1 ELISA Kits)) of Ca2 (show CA2 ELISA Kits)+ in synaptic vesicles without altering rate of priming into RRP (show RRBP1 ELISA Kits); Syt1 (show SYT1 ELISA Kits)/Syt7 functions appear redundant.
synaptotagmin 7 (Syt7) is a calcium sensor that is required for facilitation at several central synapses
Use of neurons from double-knock-out (SNAP-25 (show SNAP25 ELISA Kits), synaptotagmin-7) mice in combination with viral transduction showed that SNAP-23 (show SNAP23 ELISA Kits)-driven release is triggered by endogenous synaptotagmin-7
Complex of syt 7 and calmodulin serves as a key regulator of synaptic vesicle replenishment in presynaptic nerve terminals.
synaptotagmin-7 is directly activated by GLP-1 (show GCG ELISA Kits) signaling and may serve as a drug target for boosting insulin (show INS ELISA Kits) secretion.
knock-out of synaptotagmin-7 selectively impaired delayed asynchronous neurotransmitter release but not synchronous release. In contrast, the readily releasable vesicles after depletion recover normally in knock-out mice.
Ca(2 (show CA2 ELISA Kits)+)-triggered release at a synapse is due to synaptotagmins, with synaptotagmin-7 mediating a slower form of Ca(2 (show CA2 ELISA Kits)+)-triggered release that is normally occluded by faster synaptotagmin-1 (show SYT1 ELISA Kits)-induced release but becomes manifest upon synaptotagmin-1 (show SYT1 ELISA Kits) deletion
Results demonstrate that synaptotagmin-7 functions as a positive regulator of GLP-1 (show GCG ELISA Kits) secretion in intestinal L-cells and GLUTag cells, consistent with its proposed role as a calcium sensor in GLP-1 (show GCG ELISA Kits) secretion.
Somatodendritic dopamine release requires synaptotagmin 4 (show SYT4 ELISA Kits) and 7 and the participation of voltage-gated calcium channels.
In synaptotagmin-7 KO mice defective insulin (show INS ELISA Kits) secretion and reduced insulin (show INS ELISA Kits) sensitivity were not sufficient to cause hyperglycaemia in the absence of enhanced glucagon (show GCG ELISA Kits) secretion
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, synaptotagmin VII
, synaptotagmin 7
, prostate cancer-associated protein 7