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SYT11 is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Additionally we are shipping Synaptotagmin XI Proteins (6) and many more products for this protein.
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The genetic variations of VAMP2 (show VAMP2 Antibodies), Synaptotagmin XI might be indication of the relationship between these genes and idiopathic generalized epilepsy
parkin (show PARK2 Antibodies) interacts with and ubiquitinates synaptotagmin XI
Lack of disease-causing mutations in a detailed analysis of a large sample of familial and sporadic Parkinson's disease patients argues against a major role of mutations in the synaptotagmin XI gene in PD.
Excessive expression of Syt11 can be associated with schizophrenia.
Syt (show SS18 Antibodies) XI is directly degraded by the zinc metalloprotease (show ADAMTS7 Antibodies) GP63 (show LMLN Antibodies) and excluded from Leishmania parasitophorous vacuoles by the promastigotes surface glycolipid lipophosphoglycan.
Syt11 may provide a link between gene regulation by microRNAs and membrane traffic.
Syt (show SS18 Antibodies) XI is expressed in murine macrophages, localized in recycling endosomes, lysosomes, and recruited to phagosomes; Syt (show SS18 Antibodies) XI is a regulator of cytokine secretion, particle uptake, and macrophage microbicidal activity.
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature.
, synaptotagmin 12
, synaptotagmin 11