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Synaptotagmin-Like 4 Proteins (SYTL4)

SYTL4 encodes a member of the synaptotagmin like protein family. Additionally we are shipping SYTL4 Antibodies (30) and SYTL4 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SYTL4 94121 Q96C24
SYTL4 27359 Q9R0Q1
SYTL4 140594 Q8VHQ7
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Top SYTL4 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,952.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

SYTL4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

Rat (Rattus)

More Proteins for Synaptotagmin-Like 4 (SYTL4) Interaction Partners

Human Synaptotagmin-Like 4 (SYTL4) interaction partners

  1. GLUT5 required an interaction cascade of Rab11 (show RAB11A Proteins), Myo5B, Slp4a, Munc18-2 (show STXBP2 Proteins), and Vamp7 (show VAMP7 Proteins) with Stx3 (show STX3 Proteins).

  2. Phosphatidylinositol 4,5-bisphosphate binds to the concave surface of granuphilin-C2A domain. The key residues involved in the binding were validated by mutation analysis.

  3. the mechanisms of granuphilin plasma membrane targeting and release

  4. Recruitment of STXBP1 (show STXBP1 Proteins) by the Rab27A (show RAB27A Proteins) effector SYTL4 promotes Weibel-Palade body exocytosis.

  5. Slp4 (show S1PR4 Proteins) and Rab8 (show RAB8A Proteins) are expressed and interact in human platelets, and might be involved in dense granule release.

  6. in insulin (show INS Proteins)-producing cells adequate levels of mir (show MLXIP Proteins)-9 are mandatory for maintaining appropriate Granuphilin levels and optimal secretory capacity

  7. Synaptotagmin-like protein 4 (Slp4)/granuphilin-a contains an N-terminal Slp (show SEPT9 Proteins) homology domain (SHD (show SHD Proteins)) (PMID: 11327731). The SHD (show SHD Proteins) of Slp4 (show S1PR4 Proteins) specifically and directly binds the GTP (show AK3 Proteins)-bound form of Rab3A (show RAB3A Proteins), Rab8 (show RAB8A Proteins), and Rab27A (show RAB27A Proteins).

Mouse (Murine) Synaptotagmin-Like 4 (SYTL4) interaction partners

  1. Granuphilin and exophilin7, differentially regulate the exocytosis of either stably or minimally docked granules, respectively.

  2. granuphilin binds to syntaxin-2 (show STX2 Proteins) and syntaxin-3 (show STX3 Proteins) as well as syntaxin-1a (show STX1A Proteins), it likely mediates granule docking through interactions with those multiple syntaxins on the plasma membrane.

  3. granuphilin promotes the plasma membrane targeting of insulin (show INS Proteins) granules via interaction with syntaxin 1a (show STX1A Proteins)

  4. It is shown that the granuphilin promoter is a target of SREBP-1c (show SREBF1 Proteins), a transcription factor that controls fatty acid synthesis, and MafA (show MAFA Proteins), a beta (show SUCLA2 Proteins) cell differentiation factor

  5. Synaptotagmin-like protein 4 (Slp4)/granuphilin-a contains an N-terminal Slp (show SEPT9 Proteins) homology domain (SHD (show SHD Proteins)) (PMID: 11327731). The SHD (show SHD Proteins) of Slp4 specifically and directly binds the GTP (show AK3 Proteins)-bound form of Rab3A (show RAB3A Proteins), Rab8 (show RAB8A Proteins), and Rab27A (show RAB27A Proteins).

SYTL4 Protein Profile

Protein Summary

This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein.

Gene names and symbols associated with Synaptotagmin-Like 4 Proteins (SYTL4)

  • synaptotagmin-like 4 (granuphilin-a) (SYTL4)
  • synaptotagmin-like 4 (sytl4)
  • synaptotagmin-like 4 (SYTL4)
  • synaptotagmin-like 4 (Sytl4)
  • Gph protein
  • Slp4 protein

Protein level used designations for Synaptotagmin-Like 4 Proteins (SYTL4)

synaptotagmin-like 4 (granuphilin-a) , synaptotagmin-like 4 , exophilin-2 , granuphilin-a , synaptotagmin-like protein 4 , granuphilin , granuphilin-b , granuphilin b

GENE ID SPECIES
422260 Gallus gallus
446280 Xenopus laevis
100023319 Monodelphis domestica
100057306 Equus caballus
100155912 Sus scrofa
100539153 Meleagris gallopavo
100589791 Nomascus leucogenys
94121 Homo sapiens
27359 Mus musculus
140594 Rattus norvegicus
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