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Syndecan 1 Proteins (SDC1)

The protein encoded by SDC1 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. Additionally we are shipping Syndecan 1 Antibodies (366) and Syndecan 1 Kits (62) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SDC1 6382 P18827
SDC1 20969 P18828
SDC1 25216 P26260
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Top Syndecan 1 Proteins at

Showing 10 out of 41 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag Human Syndecan-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%. 100 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
Yeast Rat His tag Syndecan 1 (SDC1) (AA 23-257) protein (His tag) 500 μg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Human Cells Rat Fc Tag 100 μg Log in to see 16 Days

SDC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
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Mouse (Murine) , ,
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Rat (Rattus) , ,
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Top referenced Syndecan 1 Proteins

  1. Human SDC1 Protein expressed in Escherichia coli (E. coli) - ABIN1098237 : Rawstron: Immunophenotyping of plasma cells. in Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2008 (PubMed)
    Show all 2 references for ABIN1098237

  2. Human SDC1 Protein expressed in HEK-293 Cells - ABIN2180684 : Bhatt, Erdjument-Bromage, Tempst, Craik, Moasser: Adhesion signaling by a novel mitotic substrate of src kinases. in Oncogene 2005 (PubMed)
    Show all 2 references for ABIN2180684

  3. Human SDC1 Protein expressed in Human Cells - ABIN2004277 : Zou, Chen, Zong, Ye, Tang, Meng, An, Zhang, Yang: Immunotherapy based on bispecific T-cell engager with hIgG1 Fc sequence as a new therapeutic strategy in multiple myeloma. in Cancer science 2015 (PubMed)

More Proteins for Syndecan 1 (SDC1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Syndecan 1 (SDC1) interaction partners

  1. all detectable Sdc found at the NMJ is provided by the muscle, strongly suggesting a post-synaptic role for Sdc. both the cytoplasmic and extracellular domains of Sdc are required to promote synapse growth or to rescue Sdc loss of function.

  2. We conclude that Sdc cell autonomously regulates Slit/Robo2 signalling in tracheal cells to guarantee ordered directional migration and branch fusion.

  3. In this study, we provide evidence that Dlp (show DMD Proteins) and Sdc have both overlapping and distinct functions in axon guidance and in defining accurate patterns of axonal fasciculation within the lateral CNS neuropil

  4. Syndecan acting as a co-receptor for Slit in the Drosophila heart.

  5. Syndecan (Sdc) is critical for the fidelity of Slit repellent signaling at the midline of the Drosophila CNS.

  6. The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR (show PTPRF Proteins) receptor tyrosine phosphatase (show PTPRU Proteins).

  7. Dlp (show DMD Proteins), which lacks chondroitin sulfate (CS)modifications, participates in the transfer of Slit from its site of expression to the target cells, where CS-modified Sdc concentrates and presents the ligand.

Human Syndecan 1 (SDC1) interaction partners

  1. epithelial cytoplasmic expression of maspin (show SERPINB5 Proteins) and CD138 may have a significant role in tumorigenesis in ovarian high-grade serous carcinomas and clear cell carcinomas; these markers may regulate tumor cell proliferation, and their significant correlation to each other may suggest that CD138 probably induces maspin (show SERPINB5 Proteins) expression to protect tumor growth factors from being lysed by proteolytic enzymes

  2. High syndecan level is associated with sepsis.

  3. Systemic sclerosis (SSc (show CYP11A1 Proteins)) patients with elevated serum syndecan-1 levels had higher prevalence of telangiectasia, elevated right ventricular systolic pressure and decreased diffuse capacity of the lung for carbon monoxide than those with normal levels. Therefore, soluble syndecan-1 may be related to the development of proliferative vasculopathy in SSc (show CYP11A1 Proteins) patients.

  4. in colorectal adenomas, the heparanase-1 (show HPSE Proteins) does not participate in syndecan-1 degradation; the heparanase-2 does not stimulate syndecan-1 degradation by the action of heparanase-1 (show HPSE Proteins), and the heparanase-2 may be involved in the modulation of the heparanase-1 (show HPSE Proteins) activity.

  5. Targeting Syndecan-1, a molecule implicated in the process of vasculogenic mimicry, enhances the therapeutic efficacy of the L19 (show RPL19 Proteins)-IL2 (show IL2 Proteins) immunocytokine in human melanoma xenografts.

  6. The new markers were able to identify a clonal CD138-negative population as minimal residual disease in the bone marrow and peripheral blood of MM patients.

  7. miR (show MLXIP Proteins)-145 suppresses syndecan-1 and, by this mechanism, up-regulates stem cell factors and induces cell senescence and differentiation.

  8. The results suggest that Sdc1 may modulate fibronectin (show FN1 Proteins) fibrillogenesis and/or alter cell morphology during ECM (show MMRN1 Proteins) production through alphavbeta3 integrin, thereby mediating ECM (show MMRN1 Proteins) fiber alignment.

  9. Syndecan-1 on epithelial tumor cells promotes MIF (show AMH Proteins) binding and MIF (show AMH Proteins)-mediated cell migration. This may represent a relevant mechanism through which MIF (show AMH Proteins) enhances tumor cell motility and metastasis.

  10. SULF1 (show SULF1 Proteins) levels are lower in pleural malignancies compared to benign conditions and inversely correlate with the amounts of syndecan-1, suggesting important roles for syndecan-1 and SULF1 (show SULF1 Proteins) in malignant mesothelioma.

Mouse (Murine) Syndecan 1 (SDC1) interaction partners

  1. This study indicates that, while syndecan-1 is important for providing a barrier to acute S. aureus infection in PD, it does not affect peritoneal fibrosis and angiogenesis.

  2. Data suggest a potential mechanism of diabetic enteropathy, which is depending remarkably on syndecan-1 (Sdc1) and -beta-D-glucuronidase (show GUSB Proteins) heparanase (HPSE (show HPSE Proteins)).

  3. Study showed the expression, distribution and function of syndecan-1 in primary sensory neurons after nerve injury

  4. A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 (show ADAM17 Proteins) and promotes lung epithelial tumor cell migration and lung metastasis formation.

  5. The PPARgamma (show PPARG Proteins) agonist rosiglitazone rescues Sdc1-/- intradermal adipose tissue, placing PPARgamma (show PPARG Proteins) downstream of Sdc1 in triggering adipocyte differentiation

  6. Specific structural motifs in syndecan-1 HS promote Staphylococcus aureus corneal infection by inhibiting neutrophil CRAMP.

  7. Syndecan-1 is expressed in the parietal peritoneum microvasculature but does not regulate leukocyte recruitment and is not necessary for the presentation of the chemokine (show CCL1 Proteins) MIP-2 (show CXCL2 Proteins) in this tissue.

  8. These results demonstrate that defective motility in Sdc-1(-/-) macrophages promotes a persistent inflammatory state with relevance to the pathogenesis of atherosclerosis.

  9. Sdc1 affects arteriogenesis in response to hindlimb ischemia and is required in the local tissue environment for normal arteriogenesis.

  10. Syndecan-1 promotes vascular smooth muscle cell differentiation and quiescence.

Cow (Bovine) Syndecan 1 (SDC1) interaction partners

  1. Heparan sulfate is involved in both centralized and decentralized glycocalyx-mediated mechanotransduction, with GPC1 (show GPC1 Proteins) acting as a centralized agent and SDC1 functioning in decentralized mechanotransmission. GPC1 (show GPC1 Proteins) mediates NOS3 (show NOS3 Proteins) activation.

Syndecan 1 (SDC1) Protein Profile

Protein Summary

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.

Gene names and symbols associated with Syndecan 1 Proteins (SDC1)

  • Syndecan (Sdc)
  • syndecan 1 (sdc1)
  • syndecan 1 (SDC1)
  • syndecan 1 (Sdc1)
  • syndecan 1-like (LOC100338470)
  • AA408134 protein
  • AA409076 protein
  • CD138 protein
  • CG10497 protein
  • CT27296 protein
  • Dmel\\CG10497 protein
  • dSdc protein
  • Dsyn protein
  • HSPG protein
  • l(2)10608 protein
  • SDC protein
  • SDC1 protein
  • Sstn protein
  • syd protein
  • syn protein
  • syn-1 protein
  • Syn1 protein
  • Synd protein
  • Synd1 protein
  • SYNDECA protein
  • Syndecan protein
  • Syndecan-1 protein
  • syndecan1 protein
  • xSyn1 protein
  • XSyndecan-1 protein

Protein level used designations for Syndecan 1 Proteins (SDC1)

CG10497-PA , CG10497-PB , CG10497-PC , CG10497-PD , CG10497-PE , CG10497-PF , CG10497-PG , Sdc-PA , Sdc-PB , Sdc-PC , Sdc-PD , Sdc-PE , Sdc-PF , Sdc-PG , dSyndecan , syndecan , syndecan 1 , CD138 antigen , heparan sulfate proteoglycan fibroblast growth factor receptor , syndecan proteoglycan 1 , syndecan-1 , synstatin , SYND1

37447 Drosophila melanogaster
100038138 Xenopus (Silurana) tropicalis
459052 Pan troglodytes
482986 Canis lupus familiaris
701544 Macaca mulatta
6382 Homo sapiens
20969 Mus musculus
529759 Bos taurus
25216 Rattus norvegicus
100519770 Sus scrofa
421960 Gallus gallus
101836998 Mesocricetus auratus
100689057 Cricetulus griseus
100338470 Oryctolagus cuniculus
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