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The protein encoded by SDC4 is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. Additionally we are shipping Syndecan 4 Kits (43) and Syndecan 4 Proteins (33) and many more products for this protein.
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Human Polyclonal SDC4 Primary Antibody for EIA, WB - ABIN955029
Bühligen, Himmel, Gebhardt, Simon, Ziegler, Averbeck: Lysophosphatidylcholine-mediated functional inactivation of syndecan-4 results in decreased adhesion and motility of dendritic cells. in Journal of cellular physiology 2010
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We show here that sdc2 (show SDC2 Antibodies),sdc3 (show SDC3 Antibodies) and sdc4 are expressed in the zebrafish embryonic brain during the major period of axon growth. These genes show differing expression patterns in the brain which provides putative insights into their functional specificity.
cell adhesion properties of syndecan-4 are consistent across the vertebrate spectrum and reflect an early acquisition of specialization after syndecan (show SDC1 Antibodies) gene duplication events at the invertebrate/early chordate boundary
Dynamic changes in syndecan-4- and glypican-1 (show GPC1 Antibodies)-positive satellite cells indicate that they are differentially expressed during myogenesis.
The cytoplasmic domain of syndecan-4 is required for cell migration and RhoA (show RHOA Antibodies) activation in skeletal muscle satellite cells.
results suggest that syndecan-4 and its side chains play important roles in regulating FAK (show PTK2 Antibodies) activity, and PKCalpha (show PKCa Antibodies) and beta1-integrin cell membrane localization, but not cell apoptosis and vinculin (show VCL Antibodies)-containing focal adhesion formation in satellite cells
These data suggested that expression of the myogenic regulatory transcription factors are dependent upon expression of glypican-1 (show GPC1 Antibodies) and syndecan-4 during satellite cell proliferation and differentiation, and Pax7 (show PAX7 Antibodies) expression is influenced by glypican-1 (show GPC1 Antibodies).
syndecan-1 (show SDC1 Antibodies), syndecan-4, or glypican-1 (show GPC1 Antibodies) differentially affect the processes of turkey muscle cell proliferation and differentiation, and can regulate these developmental stages in an FGF2 (show FGF2 Antibodies)-independent manner
results suggest that SDC4 alleles affect lipid profile in elderly subjects and may in part mediate the link between LDL-C and longevity.
Synd4 shedding is a molecular pathological alteration in the development and maintenance of inflammation-associated atrial fibrillation.
Syndecan-4 is essential for transmitting the mechanotransduction signals via activation of PKC-alpha and is important for tumor cells spreading, assembly of actin cytoskeleton and cell contractility.
demonstrate that HER2 (show ERBB2 Antibodies) is captured via a site, comprised of amino acids 210-240, in the extracellular domain of human Sdc1 (show SDC1 Antibodies), and EGFR (show EGFR Antibodies) is captured via an extracellular site comprised of amino acids 87-131 in human Sdc4
Dynamic catch of a Thy-1 (show THY1 Antibodies)-integrin alpha5beta1+syndecan-4 trimolecular complex explains extraordinary cancer cell adhesion to the vascular endothelium.
Syndecan-4 polymorphisms were associated with essential hypertension, body mass index, and coronary artery disease prevalence in the Tampere adult population cardiovascular risk study.
No association was found with SDC4 and breast cancer.
Data indicate that depletion of syndecan 4 (S4) in umbilical vein endothelial cells (HUVECs) using shRNA inhibited flow-induced alignment in vitro, which was rescued by re-expression of S4.
define a role for TG2 (show TGM2 Antibodies) activity at the surface of human macrophages in multiple stages of AC clearance and we propose that TG2 (show TGM2 Antibodies), in association with heparan sulphates may exert its effect on AC clearance via a mechanism involving the crosslinking of CD44 (show CD44 Antibodies)
syndecan 4 is the predominant heparan sulfate proteoglycan in the glomerular endothelial cells glycocalyx
Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice.
SDC4 plays an important role in asthma induction. Disturbed SDC4 signalling leads to an impaired motility and directional migration of antigen-presenting dendritic cells.
Syndecan-4 exerts a dual role in collagen cross-linking, one involving its cytosolic domain and calcineurin (show PPP3CA Antibodies)/nuclear factor of activated T-cells signalling leading to collagen
Locally generated Sdc4 may play a role in regulating TRPC6 (show TRPC6 Antibodies) channels, and may contribute to glomerular pathology.
Sdc4 contributes to the development of collagen induced arthritis by promoting germinal center formation and autoantibody production through its regulation of SDF-1 (show CXCL12 Antibodies)-mediated B cell migration.
binding interaction between syndesmos (show NUDT16L1 Antibodies) and syn4 (show STX4 Antibodies)(cyto) was characterized as a low-affinity interaction (Kd = 62 muM) by surface plasmon resonance and nuclear magnetic resonance
the crucial role of SDC-4 for neuron density, neurite length, and branches.
SDC4 participates in amelogenesis, and FGF10 (show FGF10 Antibodies) may modulate dental epithelial cell behaviors through the regulation of SDC4 expression.
Data show that endothelial cells (ECs) from the thoracic aortas of syndecan 4 (S4-/-) mice were poorly aligned in the direction of the flow.
Sdc4 is required for cell surface targeting of transglutaminase 2 (show TGM2 Antibodies) and the development of kidney fibrosis in chronic kidney disease.
Findings suggest that syndecan-4 may be involved in acquisition of resistance to detachment-induced cell death (anoikis resistance) in endothelial cells, thus contributing to cell transformation.
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22.
, ryudocan core protein
, syndecan 4 like
, heparan sulfate proteoglycan
, syndecan 4 (amphiglycan, ryudocan)
, ryudocan amphiglycan
, syndecan proteoglycan 4
, Ryudocan/syndecan 4