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The protein encoded by SYNM is an intermediate filament (IF) family member. Additionally we are shipping Synemin, Intermediate Filament Protein Antibodies (10) and many more products for this protein.
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alpha-Synemin localizes to the M-band of the sarcomere through interaction with the M10 region of titin (show TTN Proteins)
Immunohistochemistry of synemin in reactive astrocytes and Rosenthal fibers in two patients with Alexander disease. There was an abundance of GFAP (show GFAP Proteins)-positive Rosenthal fibers and widespread reactive gliosis in the white matter and subpial regions.
synemin positively regulates glioblastoma cell proliferation by helping sequester PP2A (show PPP2R4 Proteins) away from Akt (show AKT1 Proteins), thereby favoring Akt (show AKT1 Proteins) activation.
Synemin knock-down did not influence the cytoskeleton expression and organization of human Chang liver cells
SYNM could represent a novel putative breast tumor suppressor gene that is prone to epigenetic silencing. SYNM promoter methylation may become a useful predictive biomarker to stratify breast cancer patients' risk for tumor relapse.
Desmuslin expression is required for the maintenance of vascular smooth muscle phenotype. Decreased desmuslin expression may affect differentiation of VSMCs and ultimately contribute to the development of varicose veins.
The differences in human syncoilin (show Sync Proteins) and beta-synemin mRNA ratios between Duchenne muscular dystrophy (show DMD Proteins) and normal muscles were not statistically significant
The LIM domain protein (show CSRP1 Proteins) zyxin (show ZYX Proteins) was identified as an interaction partner for human synemin.
Genomic organization and single-nucleotide polymorphism map of desmuslin, a novel intermediate filament protein (show DES Proteins) on chromosome 15q26.3.
Expression of the intermediate filament protein (show DES Proteins) synemin in myofibrillar myopathies and other muscle diseases.
Suggest that synemin contributes to linkage between costameres and the contractile apparatus and that the absence of synemin results in decreased fiber size and increased sarcolemmal deformability and susceptibility to injury.
results show that synemin is necessary to maintain membrane integrity and regulates signalling molecules during muscle hypertrophy.
synemin gene encodes proteins belonging to the intermediate filament which confer resistance to mechanical stress and modulate cell shape.
Dmn is expressed in reactive astrocytes in neurotrauma and interacts differentially with Vim (show VIM Proteins) and Gfap (show GFAP Proteins).
Alpha- and beta-synemin transcripts and their encoded proteins colocalize in neurons, especially in the midbrain and pons.
Synemin isoforms during mouse development.
These analyses show that synemin transcript and its encoded protein colocalize in the anterior horn cells and that no differences in synemin expression were found in nerve tissue from C57BL/6 or mdx (show DMD Proteins) mice.
The protein encoded by this gene is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants encoding different isoforms have been described for this gene.
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