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SYVN1 encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. Additionally we are shipping Synovial Apoptosis Inhibitor 1, Synoviolin Antibodies (93) and Synovial Apoptosis Inhibitor 1, Synoviolin Proteins (7) and many more products for this protein.
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The inherently unstable nature of the human SEL1L (show SEL1L ELISA Kits) protein lies in its transmembrane domain, and that association of HRD1 with the SEL1L (show SEL1L ELISA Kits) transmembrane domain restored its stability.
specific silencing of Derlin-2 (show DERL2 ELISA Kits), p97 (show EIF4G2 ELISA Kits) and HRD1 by shRNAs increases steady state levels of proinsulin (show INS ELISA Kits). these ERAD constituents are critically involved in proinsulin (show INS ELISA Kits) degradation and may therefore also play a role in subsequent antigen generation.
Charcot-Marie-Tooth disease-related PMP22 (show PMP22 ELISA Kits) is trapped in the endoplasmic reticulum by calnexin (show CANX ELISA Kits)-dependent retention and Rer1 (show RER1 ELISA Kits)-mediated early Golgi retrieval systems and partly degraded by the Hrd1-mediated endoplasmic reticulum-associated degradation system.
Results show that HRD1 and RFP2 (show TRIM13 ELISA Kits) contributes are required for the disposal of V247M alpha-sarcoglycan (show SGCA ELISA Kits) mutant.
Herp localizes to the endoplasmic reticulum-derived quality control compartment (ERQC) and recruits HRD1, which targets to endoplasmic reticulum associated degradation the substrate presented by the OS-9 lectin at the ERQC.
HRD1 and RMA1 may therefore be negative regulators of disease-associated transporter ABCG5 (show ABCG5 ELISA Kits)/ABCG8 (show ABCG8 ELISA Kits).
identified Hrd1 as a novel E3 ubiquitin ligase responsible for compromised Nrf2 (show GABPA ELISA Kits) response during liver cirrhosis
a new HRD1-associated membrane protein named HERP2 (show HEY1 ELISA Kits), which is homologous to the previously identified HRD1 partner HERP1 (show HEY2 ELISA Kits). Despite sequence homology, HERP2 (show HEY1 ELISA Kits) is constitutively expressed in cells, whereas HERP1 (show HEY2 ELISA Kits) is highly induced by ER stress.
the interactions between P97 (show EIF4G2 ELISA Kits) and these motifs, including VCP (show vcp ELISA Kits)-binding motif (VBM) and VCP (show vcp ELISA Kits)-interacting motif (VIM (show VIM ELISA Kits)). The solution structures of the VBM motif from HRD1 and the VIM (show VIM ELISA Kits) motif from SVIP (show SVIP ELISA Kits) are both comprised mainly of a single alpha-helix.
derlin2 functions with HRD1 in ERAD of certain substrates independent of their glycosylation status.
SYVN1 may play an important role in inhibiting ER stress, chronic inflammation, and vascular overgrowth associated with DR.
Data show that inositol requiring enzyme 1alpha (IRE1alpha (show ERN1 ELISA Kits)), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L (show SEL1L ELISA Kits) proten-Hrd1 protein endoplasmic reticulum (ER)-associated degradation (ERAD) complex.
Hrd1 is an essential component of the adaptive endoplasmic reticulum stress response in cardiac myocytes.
The results highlight a novel function for SYVN1 in the control of body weight and mitochondrial biogenesis through negative regulation of PGC (show PGC ELISA Kits)-1b.
Data indicate that E3 ubiquitin-protein ligase (show UBE2K ELISA Kits) Hrd1 catalyzed ubiquitination and degradation of the transcriptional suppressor B lymphocyte-induced maturation protein 1 (BLIMP1 (show PRDM1 ELISA Kits)) to promote MHC-II antigen expression.
oxidative stress-induced (show SQSTM1 ELISA Kits) HRD1 insolubilization might be involved in a vicious cycle of increased amyloid beta production and amyloid beta-induced oxidative stress in Alzheimer's disease pathogenesis.
results indicate that Hrd1 plays an important role in the maturation of collagen I in renal fibrosis, and that Sec23A (show SEC23A ELISA Kits) pathway is required for ER-to-Golgi procollagen trafficking to promote collagen synthesis
Synoviolin up-regulates amyloid beta production by targeting a negative regulator of gamma-secretase, Rer1 (show RER1 ELISA Kits), for degradation.
HRD1 is colocated with the neural stem cell marker protein nestin (show NES ELISA Kits) and glial fibrillary acidic protein (show GFAP ELISA Kits) in the endoplasmic reticulum membrane of the NSCs of the subventricular zone (SVZ astrocytes) but in the cell nucleus of in the dentate gyrus
these results clearly suggest that both beta-TrCP (show BTRC ELISA Kits)- and Hrd1-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 (show NRF1 ELISA Kits) to maintain cellular homeostasis.
This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms.
E3 ubiquitin-protein ligase synoviolin
, synovial apoptosis inhibitor 1, synoviolin
, HMG-coA reductase degradation 1 homolog
, synoviolin 1
, HRD1 protein