Synovial Sarcoma, X Breakpoint 1 Proteins (SSX1)

The product of SSX1 belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. Additionally we are shipping Synovial Sarcoma, X Breakpoint 1 Antibodies (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SSX1 6756 Q16384
Rat SSX1 SSX1 691903  
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Top Synovial Sarcoma, X Breakpoint 1 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$319.00
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$382.86
Details

SSX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

Top referenced Synovial Sarcoma, X Breakpoint 1 Proteins

  1. Human SSX1 Protein expressed in Wheat germ - ABIN1321448 : Smith, Cronk, Lang, McNeel: Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancer. in Cancer research 2011 (PubMed)

More Proteins for Synovial Sarcoma, X Breakpoint 1 (SSX1) Interaction Partners

Human Synovial Sarcoma, X Breakpoint 1 (SSX1) interaction partners

  1. In patients with Colon cancer, the expression of SSX1 gene was associated with a poor prognosis.

  2. Meta-analysis of human synovial sarcoma patient series identified two tumor-gentoype-phenotype correlations that were not modeled by the mice, namely a scarcity of male hosts and biphasic histologic features among SS18 (show SS18 Proteins)-SSX2 (show SSX2 Proteins) tumors. Re-analysis of human SS18 (show SS18 Proteins)-SSX1 and SS18 (show SS18 Proteins)-SSX2 (show SSX2 Proteins) tumor transcriptomes demonstrated very few consistent differences, but highlighted increased native SSX2 (show SSX2 Proteins) expression in SS18 (show SS18 Proteins)-SSX1 tumors.

  3. Data show that SS18 (show SS18 Proteins)/SSX (show SSX2 Proteins) tightly regulates the elevated expression of the key Wnt (show WNT2 Proteins) target AXIN2 (show AXIN2 Proteins) in primary synovial sarcoma.

  4. a rare variant of the SS18 (show SS18 Proteins)-SSX1 fusion transcript, which could not be identified by routine procedures for genetic diagnosis, was detected. In addition, 8 missense mutations of cancer-related genes were confirmed

  5. SS18 (show SS18 Proteins)-SSX (show SSX2 Proteins)-induced Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling appears to be of crucial biological importance in synovial sarcoma tumorigenesis and progression.

  6. The mRNA levels of SSX1 and SSX4 are associated with multiple myeloma clinical stage

  7. These results suggest that the characteristic speckle localization pattern of SS18 (show SS18 Proteins)-SSX (show SSX2 Proteins) is strongly involved in the tumorigenesis through the SSX (show SSX2 Proteins) moiety of the SS18 (show SS18 Proteins)-SSX (show SSX2 Proteins) fusion protein.

  8. Knockdown of SS18 (show SS18 Proteins)-SSX1 in synovial sarcoma inhibits viability and induces apoptosis.

  9. Study shows that the SS18 (show SS18 Proteins)-SSX1 oncogenic fusion usurps SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins)-like BAF (show BANF1 Proteins) complexes, resulting in activation of Sox2 (show SOX2 Proteins), which drives proliferation.

  10. siRNA targeting of SS18 (show SS18 Proteins)-SSX1 has therapeutic potential for the treatment of synovial sarcoma.

Synovial Sarcoma, X Breakpoint 1 (SSX1) Protein Profile

Protein Summary

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X\\\\;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity.

Gene names and symbols associated with SSX1

  • synovial sarcoma, X breakpoint 1 (SSX1)
  • synovial sarcoma, X breakpoint 1 (Ssx1)
  • CT5.1 protein
  • SSRC protein

Protein level used designations for SSX1

protein SSX1 , cancer/testis antigen 5.1 , cancer/testis antigen family 5, member 1 , sarcoma, synovial, X-chromosome-related 1 , synovial sarcoma, X breakpoint 1

GENE ID SPECIES
6756 Homo sapiens
691903 Rattus norvegicus
736918 Pan troglodytes
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