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The product of SSX1 belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. Additionally we are shipping Synovial Sarcoma, X Breakpoint 1 Antibodies (36) and many more products for this protein.
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Human SSX1 Protein expressed in Wheat germ - ABIN1321448
Smith, Cronk, Lang, McNeel: Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancer. in Cancer research 2011
In patients with Colon cancer, the expression of SSX1 gene was associated with a poor prognosis.
Meta-analysis of human synovial sarcoma patient series identified two tumor-gentoype-phenotype correlations that were not modeled by the mice, namely a scarcity of male hosts and biphasic histologic features among SS18 (show SS18 Proteins)-SSX2 (show SSX2 Proteins) tumors. Re-analysis of human SS18 (show SS18 Proteins)-SSX1 and SS18 (show SS18 Proteins)-SSX2 (show SSX2 Proteins) tumor transcriptomes demonstrated very few consistent differences, but highlighted increased native SSX2 (show SSX2 Proteins) expression in SS18 (show SS18 Proteins)-SSX1 tumors.
Data show that SS18 (show SS18 Proteins)/SSX (show SSX2 Proteins) tightly regulates the elevated expression of the key Wnt (show WNT2 Proteins) target AXIN2 (show AXIN2 Proteins) in primary synovial sarcoma.
a rare variant of the SS18 (show SS18 Proteins)-SSX1 fusion transcript, which could not be identified by routine procedures for genetic diagnosis, was detected. In addition, 8 missense mutations of cancer-related genes were confirmed
SS18 (show SS18 Proteins)-SSX (show SSX2 Proteins)-induced Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling appears to be of crucial biological importance in synovial sarcoma tumorigenesis and progression.
The mRNA levels of SSX1 and SSX4 are associated with multiple myeloma clinical stage
These results suggest that the characteristic speckle localization pattern of SS18 (show SS18 Proteins)-SSX (show SSX2 Proteins) is strongly involved in the tumorigenesis through the SSX (show SSX2 Proteins) moiety of the SS18 (show SS18 Proteins)-SSX (show SSX2 Proteins) fusion protein.
Knockdown of SS18 (show SS18 Proteins)-SSX1 in synovial sarcoma inhibits viability and induces apoptosis.
Study shows that the SS18 (show SS18 Proteins)-SSX1 oncogenic fusion usurps SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins)-like BAF (show BANF1 Proteins) complexes, resulting in activation of Sox2 (show SOX2 Proteins), which drives proliferation.
siRNA targeting of SS18 (show SS18 Proteins)-SSX1 has therapeutic potential for the treatment of synovial sarcoma.
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X\\\\;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity.
, cancer/testis antigen 5.1
, cancer/testis antigen family 5, member 1
, sarcoma, synovial, X-chromosome-related 1
, synovial sarcoma, X breakpoint 1