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SSX2IP encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. Additionally we are shipping SSX2IP Antibodies (46) and SSX2IP Kits (3) and many more products for this protein.
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SSX2IP is required for mitotic centrosome maturation.
This study determined the crystallographic structure of human Afadin in complex with LGN (show GPSM2 Proteins).
Studied afadin in complex with beta-catenin in glomeruli and in cultured mesangial cells. Found expression of afadin at mesangial intercellular junctions was greatly decreased in mesangial proliferative nephritis in rats & patients w/glomerulonephritis.
Knockdown of Wdr8 (show WDR8 Proteins) or hMsd1/SSX2IP displayed very similar mitotic defects, in which spindle microtubules became shortened and misoriented.
SSX2IP-mediated microtubule anchoring is essential for proper centriole assembly and duplication. On SSX2IP knockdown, the centriolar satellites become stuck at the microtubule minus end near the centrosome.
In airway epithelial cells, measles virus spread requires the nectin-4/afadin complex and is based on cytoplasm transfer between columnar cells.
The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone.
results showed that SSX2IP promotes the development and metastasis of hepatocellular carcinoma and contributes to the drug resistance of hepatoma cells
Nuclear protein SS2IP interacts with cancer-related protein SSX2 and the human homologue of a Ras-like GTPase interactor, RABIN3.
data shows that SSX2IP is affected in two ways that relate to the cell cycling of acute myeloid leukaemia cells
The results indicate that ADIP plays an essential role in PDGF (show PDGFA Proteins)-induced cell movement by interacting with afadin and Vav2 and regulating the activation of Rac (show AKT1 Proteins).
This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.
, afadin- and alpha-actinin-binding protein
, synovial sarcoma, X breakpoint 2 interacting protein
, afadin- and alpha-actinin-binding protein-like
, SSX2-interacting protein
, afadin DIL domain-interacting protein
, light-inducible and clock-controlled
, afadin- and alpha-actinin-binding protein ADIP