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The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Additionally we are shipping Synovial Sarcoma Translocation, Chromosome 18 Antibodies (27) and Synovial Sarcoma Translocation, Chromosome 18 Kits (3) and many more products for this protein.
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One-Step reverse transcriptase real time PCR for the detection SYT-SSX (show SSX2 Proteins) transcript is feasible as an aid in confirming the diagnosis of synovial sarcoma.
membrane tethering by E-Syt1 (ER to PM) and by synaptotagmin (secretory vesicles to PM) undergo a similar regulation by plasma membrane lipids and cytosolic Ca(2 (show CA2 Proteins)+).
a rare variant of the SS18-SSX1 (show SSX1 Proteins) fusion transcript, which could not be identified by routine procedures for genetic diagnosis, was detected. In addition, 8 missense mutations of cancer-related genes were confirmed
A dominant negative de novo SYT1 (show SYT1 Proteins) missense variant(I368T)altered the kinetics of synaptic vesicle endocytosis and caused an early onset dyskinetic movement disorder, severe motor delay, and profound cognitive impairment.
Data suggest that calcium-dependent phosphatidylinositol 4,5-diphosphate- (PI(4,5)P2-) binding proteins (such as SYT1 (show SYT1 Proteins), PRKCA (show PKCa Proteins) [protein kinase C alpha (show PKCa Proteins)], and ANXA2 (show ANXA2 Proteins) [annexin A2 (show ANXA2 Proteins)]) interactions with membrane microdomains are tightly regulated. [REVIEW]
Case Report: bronchial biphasic synovial sarcoma with SS18 gene rearrangement.
SS18-SSX (show SSX2 Proteins)-induced Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling appears to be of crucial biological importance in synovial sarcoma tumorigenesis and progression.
Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 (show SYT1 Proteins) and DDR2 (show DDR2 Proteins) rearrangements.
SYT gene split is associated with Synovial sarcoma.
These results suggest that the characteristic speckle localization pattern of SS18-SSX (show SSX2 Proteins) is strongly involved in the tumorigenesis through the SSX (show SSX2 Proteins) moiety of the SS18-SSX (show SSX2 Proteins) fusion protein.
disruption of the Ss18 gene results in a recessive embryonic lethal phenotype, due to placental failure caused by impairment of placental vascularization and/or chorio-allantoic fusion
Syt may contribute to the signaling pathway important for various cellular functions in vivo and in vitro, and we propose that Syt-deficient MEFs would be a powerful means to understand the biological roles of SYT in vitro.
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001
, protein SSXT
, synovial sarcoma translocated to X chromosome protein
, synovial sarcoma, translocated to X chromosome
, synovial sarcoma associated SS18-beta
, synovial sarcoma associated SS18-delta
, synovial sarcoma associated SS18-gamma
, synovial sarcoma-associated Ss18-alpha