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STX11 encodes a member of the syntaxin family. Additionally we are shipping Syntaxin 11 Proteins (6) and many more products for this protein.
Showing 10 out of 52 products:
Human Polyclonal STX11 Primary Antibody for WB - ABIN1881853
Marsh, Satake, Biroschak, Jacobs, Johnson, Jordan, Bleesing, Filipovich, Zhang: STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America. in Pediatric blood & cancer 2010
Show all 3 references for ABIN1881853
Human Polyclonal STX11 Primary Antibody for ICC, IF - ABIN4356683
Yoshida, Tsuzuki, Karube, Takahara, Suguro, Miyoshi, Nishikori, Shimoyama, Tsukasaki, Ohshima, Seto: STX11 functions as a novel tumor suppressor gene in peripheral T-cell lymphomas. in Cancer science 2015
The results suggest that STX11 plays an important role in the pathogenesis of Peripheral T-cell lymphomas and they may contribute to the future development of new drugs for the treatment of Peripheral T-cell lymphomas.
a pivotal role for S-acylation in the function of syntaxin 11 in NK cells
Stx11 functions as a t-SNARE (show NAPA Antibodies) for the final fusion of LG at the IS.
Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1 (show PRF1 Antibodies), RAB27A (show RAB27A Antibodies), and STX11.
These data indicate that human neutrophils express syntaxin 11 and call attention to the possible involvement of neutrophils in familial hemophagocytic lymphohistiocytosis pathology
Platelets deficient in syntaxin-11 from a Familial Hemophagocytic Lymphohistiocytosis type 4 had secretion defect.
Data suggest that syntaxin 11 promotes the fusion of Rab27a (show RAB27A Antibodies)-expressing vesicles with cytotoxic granules and reveal additional complexity in spatial/temporal segregation of subcellular structures involved in granule-mediated cytotoxicity.
No detrimental mutations were identified in STX11 in Chinese children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis.
STX11 should be sequenced in HLH patients even when impaired NK cell degranulation is not found
a novel homozygous deletion (c. 581_584delTGCC; p.Leu194ProfsX2) in the gene-encoding syntaxin 11 (STX11), causing a premature termination codon in hemophagocytic lymphohistiocytosis
required for NK and CD8 (show CD8A Antibodies)+ T cell cytotoxicity and neutrophil degranulation
Blockade of inhibitory receptors on T cells in Stx11-deficient mice converted nonfatal disease course into fatal HLH, identifying T-cell exhaustion as an important factor for determination of disease severity in hemophagocytic lymphohistiocytosis.
Results suggest that by regulating the availability of Vti1b (show VTI1B Antibodies), Stx11 regulates trafficking steps between late endosomes, lysosomes and the cell surface in macrophages.
Stx11 were highly expressed at the end of fetal development but downregulated at 4 and 11 weeks in brain, pancreas, and heart.
This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis.