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Syntaxin Binding Protein 2 (STXBP2) ELISA Kits

STXBP2 encodes a member of the STXBP/unc-18/SEC1 family. Additionally we are shipping STXBP2 Antibodies (42) and STXBP2 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human STXBP2 STXBP2 6813 Q15833
Anti-Mouse STXBP2 STXBP2 20911 Q64324
Anti-Rat STXBP2 STXBP2 81804 Q62753
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More ELISA Kits for STXBP2 Interaction Partners

Human Syntaxin Binding Protein 2 (STXBP2) interaction partners

  1. two novel mutations of STXBP2: c.184A>G and c.577A>C. c.184A>G (p.Asn62Asp) was located within a highly conserved region of the STXBP2 protein and predicted to be deleterious.

  2. red blood cells express Munc18-2 and that erythroid cells from patients with FHL-5 exhibit intrinsic defects caused by STXBP2/Munc18-2 mutations.

  3. Munc18-2(R65Q) and Munc18-2(R65W) retain the ability to interact with and stabilize STX11 (show STX11 ELISA Kits). However, presence of Munc18-2(R65Q/W) in patient-derived lymphocytes and forced expression in control CTLs and NK cells diminishes degranulation and cytotoxicity.

  4. Data show that all but one patient with atypical familial hemophagocytic lymphohistiocytosis carried at least one splice-site mutation in UNC13D (show UNC13D ELISA Kits) or STXBP2.

  5. Munc18-2 binds the N-terminal peptide of Stx11 (show STX11 ELISA Kits) with a ~20-fold higher affinity than Stx3 (show STX3 ELISA Kits), suggesting a potential role in selective binding.

  6. We report that FHL-5 neutrophils have a profound defect in granule mobilization, resulting in inadequate bacterial killing, in particular, of gram-negative Escherichia coli, but not of Staphylococcus aureus.

  7. Mutations in STXBP2 do not only affect cytotoxic T lymphocytes but also cause changes in the intestinal and renal epithelium resulting in severe, osmotic diarrhea and renal proximal tubular dysfunction

  8. Double knockdown of Munc18-1 and Munc18-2 in mast cells eliminates both IgE-dependent and ionomycin-induced degranulation and causes a significant reduction in syntaxin-11 without altering expressions of the other syntaxin isoforms examined.

  9. Novel mutation in STXBP2 prevents IL-2 (show IL2 ELISA Kits)-induced natural killer cell cytotoxicity in familial hemophagocytic lymphohistiocytosis.

  10. We report the largest cohort of patients with FHL5 so far, describe an extended disease spectrum, and demonstrate for the first time a clear genotype-phenotype correlation.

Mouse (Murine) Syntaxin Binding Protein 2 (STXBP2) interaction partners

  1. Munc18b as an essential gene that is a limiting component of the exocytic machinery of epithelial cells and mast cell.

  2. Munc18-1 (show STXBP1 ELISA Kits) and Munc18-2 display distinct subcellular compartmentalization and can coordinate the insulin (show INS ELISA Kits) exocytotic process differently as a consequence of the actual [Ca(2 (show CA2 ELISA Kits)+)](i).

STXBP2 Antigen Profile

Antigen Summary

This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene names and symbols associated with STXBP2

  • syntaxin binding protein 2 (stxbp2) antibody
  • syntaxin binding protein 2 (STXBP2) antibody
  • syntaxin binding protein 2 (Stxbp2) antibody
  • C79054 antibody
  • FHL5 antibody
  • Hunc18b antibody
  • MUNC-18-2 antibody
  • Munc-18b antibody
  • MUNC18-2 antibody
  • Munc18b antibody
  • muSec1 antibody
  • pp10122 antibody
  • Sxtbp2 antibody
  • Sxtp2 antibody
  • Unc18-2 antibody
  • Unc18b antibody
  • zgc:85807 antibody

Protein level used designations for STXBP2

syntaxin-binding protein 2 , protein unc-18 homolog B , unc-18B , munc18-2 , protein unc-18 homolog 2 , syntaxin binding protein Munc18-2 , unc-18 homolog 2 , unc18-2 , Sec1 homolog

GENE ID SPECIES
406578 Danio rerio
515618 Bos taurus
100171766 Pongo abelii
6813 Homo sapiens
20911 Mus musculus
81804 Rattus norvegicus
403880 Canis lupus familiaris
100525152 Sus scrofa
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