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Syntaxin Binding Protein 5 (Tomosyn) (STXBP5) ELISA Kits

Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. Additionally we are shipping STXBP5 Antibodies (4) and STXBP5 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human STXBP5 STXBP5 134957 Q5T5C0
Anti-Mouse STXBP5 STXBP5 78808  
Anti-Rat STXBP5 STXBP5 81022 Q9WU70
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More ELISA Kits for STXBP5 Interaction Partners

Human Syntaxin Binding Protein 5 (Tomosyn) (STXBP5) interaction partners

  1. Genetic variations in STXBP5 and CLEC4M (show CLEC4M ELISA Kits) are associated with VWF (show VWF ELISA Kits) level variation in type 1, but not in type 2 von Willebrand disease.

  2. STXBP5 is required for normal arterial hemostasis, due to its contributions to platelet granule cargo packaging and secretion

  3. STXBP5 inhibits endothelial exocytosis and promotes platelet secretion

  4. Identify 3 loci associated with circulating tPA (show PLAT ELISA Kits) levels, the PLAT (show PLAT ELISA Kits) region, STXBP5, and STX2 (show STX2 ELISA Kits). Functional studies implicate a novel role for STXBP5 and STX2 (show STX2 ELISA Kits) in regulating tPA (show PLAT ELISA Kits) release.

  5. Genetic variation in STXBP5 is associated with bleeding phenotype in female type 1 von Willebrand Disease patients.

  6. Genetic variation in STXBP5 gene is associated with venous thrombosis.

  7. multiple domains outside the R-SNARE (show YKT6 ELISA Kits) of tomosyn are critical to the efficacy of inhibition by tomosyn on exocytotic secretion

  8. Genetic variability in STXBP5 and STX2 (show STX2 ELISA Kits) affects both VWF (show VWF ELISA Kits) concentration and activity in young individuals with premature arterial thrombosis.

Mouse (Murine) Syntaxin Binding Protein 5 (Tomosyn) (STXBP5) interaction partners

  1. PIASgamma-dependent modification of tomosyn-1 with SUMO-2 (show SUMO2 ELISA Kits)/3 presents a novel mechanism to adapt secretory strength to the dynamic synaptic environment.

  2. STXBP5 is required for normal arterial hemostasis, due to its contributions to platelet granule cargo packaging and secretion

  3. STXBP5 inhibits endothelial exocytosis and promotes platelet secretion

  4. regulates SNARE (show VTI1B ELISA Kits) complex formation and synaptic vesicle fusion. (review)

  5. Interacts with SNAP23 (show SNAP23 ELISA Kits) and Syntaxin4 (show STX4 ELISA Kits) and plays a role in Insulin (show INS ELISA Kits)-stimulated GLUT4 (show SLC2A4 ELISA Kits) translocacion.

  6. The interaction between syntaxin4 (show STX4 ELISA Kits) and Munc18c in adipocytes results in enhancement of insulin (show INS ELISA Kits)-stimulated GLUT4 (show SLC2A4 ELISA Kits) externalization.

  7. In the pancreatic beta-cell, tomosyn negatively regulates insulin (show INS ELISA Kits) exocytosis.

  8. Tomosyn-1 is involved in a post-docking event that prepares secretory granules for fusion and is necessary to sustain exocytosis of pancreatic beta-cells in response to insulin (show INS ELISA Kits) secretagogues.

  9. Tomosyn inhibits neurotransmitter release by catalyzing oligomerization of the SNARE complex through the N-terminal WD-40 repeat domain in addition to the inhibitory activity of the C-terminal (VAMP)-like domain.

STXBP5 Antigen Profile

Antigen Summary

Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with STXBP5

  • syntaxin binding protein 5 (tomosyn) (STXBP5) antibody
  • syntaxin binding protein 5 (tomosyn) (Stxbp5) antibody
  • 0710001E20Rik antibody
  • 4930565N16Rik antibody
  • AW742610 antibody
  • LGL3 antibody
  • LLGL3 antibody
  • mKIAA1006 antibody
  • Nbla04300 antibody

Protein level used designations for STXBP5

lethal(2) giant larvae protein homolog 3 , putative protein product of Nbla04300 , syntaxin-binding protein 5 , tomosyn , tomosyn-1 , tomosyn 1

GENE ID SPECIES
134957 Homo sapiens
78808 Mus musculus
81022 Rattus norvegicus
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