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Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. Additionally we are shipping STXBP5 Antibodies (6) and STXBP5 Proteins (3) and many more products for this protein.
Genetic variations in STXBP5 and CLEC4M (show CLEC4M ELISA Kits) are associated with VWF (show VWF ELISA Kits) level variation in type 1, but not in type 2 von Willebrand disease.
STXBP5 is required for normal arterial hemostasis, due to its contributions to platelet granule cargo packaging and secretion
STXBP5 inhibits endothelial exocytosis and promotes platelet secretion
Identify 3 loci associated with circulating tPA (show PLAT ELISA Kits) levels, the PLAT (show PLAT ELISA Kits) region, STXBP5, and STX2 (show STX2 ELISA Kits). Functional studies implicate a novel role for STXBP5 and STX2 (show STX2 ELISA Kits) in regulating tPA (show PLAT ELISA Kits) release.
Genetic variation in STXBP5 is associated with bleeding phenotype in female type 1 von Willebrand Disease patients.
Genetic variation in STXBP5 gene is associated with venous thrombosis.
multiple domains outside the R-SNARE (show YKT6 ELISA Kits) of tomosyn are critical to the efficacy of inhibition by tomosyn on exocytotic secretion
Genetic variability in STXBP5 and STX2 (show STX2 ELISA Kits) affects both VWF (show VWF ELISA Kits) concentration and activity in young individuals with premature arterial thrombosis.
PIASgamma-dependent modification of tomosyn-1 with SUMO-2 (show SUMO2 ELISA Kits)/3 presents a novel mechanism to adapt secretory strength to the dynamic synaptic environment.
regulates SNARE (show VTI1B ELISA Kits) complex formation and synaptic vesicle fusion. (review)
Interacts with SNAP23 (show SNAP23 ELISA Kits) and Syntaxin4 (show STX4 ELISA Kits) and plays a role in Insulin (show INS ELISA Kits)-stimulated GLUT4 (show SLC2A4 ELISA Kits) translocacion.
The interaction between syntaxin4 (show STX4 ELISA Kits) and Munc18c in adipocytes results in enhancement of insulin (show INS ELISA Kits)-stimulated GLUT4 (show SLC2A4 ELISA Kits) externalization.
In the pancreatic beta-cell, tomosyn negatively regulates insulin (show INS ELISA Kits) exocytosis.
Tomosyn-1 is involved in a post-docking event that prepares secretory granules for fusion and is necessary to sustain exocytosis of pancreatic beta-cells in response to insulin (show INS ELISA Kits) secretagogues.
Tomosyn inhibits neurotransmitter release by catalyzing oligomerization of the SNARE complex through the N-terminal WD-40 repeat domain in addition to the inhibitory activity of the C-terminal (VAMP)-like domain.
Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified.
lethal(2) giant larvae protein homolog 3
, putative protein product of Nbla04300
, syntaxin-binding protein 5
, tomosyn 1