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Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein.
Overexpression of mutant alpha-synuclein causes age-dependent pathological changes in brain.
In alpha-synuclein knock-out mice there was a decrease in neuronal glucose metabolism in cerebral cortex gray matter.
alpha-synuclein may have a varying modulating effect on the growth dynamics and the fate of populations of DA neurons.
In the olfactory bulb, globus pallidus and substantia nigra pars (show EPRS Antibodies) compacta, alpha-synuclein was expressed, but not in the cerebral cortex, subthalamic nucleus or thalamus.
identified alpha-synuclein as a new transcriptional target of p53 (show TP53 Antibodies)
High SNCA expression is associated with epilepsy.
Data suggest the produced mouse lines represent a set of useful tools for studies of alpha-synuclein normal function and the role of this protein in disease pathogenesis.
that loss of glucocerebrosidase (show GBA Antibodies) function may contribute to SNCA accumulation through inhibition of autophagy via PPP2A inactivation
provides evidence for a novel interaction of alpha-synuclein and SOD1 (show SOD1 Antibodies) that might be relevant for neurodegenerative diseases
It found that chromosome 1 harbors an expression quantitative trait locus that modulates Sncg (show SNCG Antibodies) expression in the mouse retina, and identified the prefoldin-2 (PFDN2 (show PFDN2 Antibodies)) gene as the candidate upstream modulator of Sncg (show SNCG Antibodies) expression.
The response of CPLX1 (show CPLX1 Antibodies) and Foxp1 (show FOXP1 Antibodies) levels to SNCA deficiency supports the notion that these factors are regulated by altered physiological function of alpha-synuclein.
An increase in striatal glial fibrillary acidic protein (show GFAP Antibodies) mRNA level 4 weeks after ASN injection into the ST.
these findings provide an evidence that the region from 32 to 58 of N-terminal lipid binding alpha helix domain of SNCA is the most critical region, not only from the evolutionary perspective but also for the stability and the proper conformation of the protein as well as crucial for the disease pathogenesis, harboring critical interaction sites.
This mathematical approach confirmed the clustering of premotor markers in preclinical stage of Parkinson's disease. This is the first report showing that alpha-synuclein in the colon and other premotor markers are related to each other in neurologically normal subjects.
Hypomethylation of CpG islands located in intron 1 of the SNCA in leukocytes of dementia with Lewy bodies.
Findings indicate that alpha-synuclein pathology in the peripheral nerves is axonal-predominant in Lewy body disease, whereas it is restricted to glial cells in multiple system atrophy.
The subgroup of PD showed higher levels of CSF (show CSF2 Antibodies) alpha-synuclein (38.3 +/- 17.8 ng/ml) than the rest (25.3 +/- 11.3 ng/ml, P = 0.012). These results suggest that PD (and MSA (show TPO Antibodies)) includes two subgroups, which show different metabolism of CSF (show CSF2 Antibodies) transferrin (show Tf Antibodies) and alpha-synuclein.
Programmed cell death protein 1 (PD1 (show PDCD1 Antibodies)) and programmed death-ligand 1 (PDL1 (show CD274 Antibodies)) status by immunohistochemistry was not associated with outcomes. The use of immune checkpoint blockade in tumors with higher mutational load was associated with improved OS. Our results suggest that the evaluation of tumor genomes may be predictive of immunotherapy benefit
SNCA variant carriers with have more favorable treatment responses to deep brain stimulation.
This study demonstrateed that the rs11931074 in SNCA association with PD risk in Iran population.
extent of phosphorylated alpha-synuclein-immunoreactive astrocytes was correlated with disease durationfa
analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (show TNFAIP1 Antibodies) [ANXB12]
Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
, non-A beta component of AD amyloid
, non-A4 component of amyloid
, non A-beta component of AD amyloid
, synuclein alpha-140
, alpha synuclein