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anti-Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) Antibodies

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse SNCA SNCA 20617 O55042
Anti-Human SNCA SNCA 6622 P37840
Anti-Rat SNCA SNCA 29219 P37377
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More Antibodies against Synuclein, alpha (Non A4 Component of Amyloid Precursor) Interaction Partners

Rhesus Monkey Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) interaction partners

  1. Overexpression of mutant alpha-synuclein causes age-dependent pathological changes in brain.

Mouse (Murine) Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) interaction partners

  1. alpha-synuclein may have a varying modulating effect on the growth dynamics and the fate of populations of DA neurons.

  2. In the olfactory bulb, globus pallidus and substantia nigra pars (show EPRS Antibodies) compacta, alpha-synuclein was expressed, but not in the cerebral cortex, subthalamic nucleus or thalamus.

  3. identified alpha-synuclein as a new transcriptional target of p53 (show TP53 Antibodies)

  4. High SNCA expression is associated with epilepsy.

  5. Data suggest the produced mouse lines represent a set of useful tools for studies of alpha-synuclein normal function and the role of this protein in disease pathogenesis.

  6. that loss of glucocerebrosidase (show GBA Antibodies) function may contribute to SNCA accumulation through inhibition of autophagy via PPP2A inactivation

  7. provides evidence for a novel interaction of alpha-synuclein and SOD1 (show SOD1 Antibodies) that might be relevant for neurodegenerative diseases

  8. It found that chromosome 1 harbors an expression quantitative trait locus that modulates Sncg (show SNCG Antibodies) expression in the mouse retina, and identified the prefoldin-2 (PFDN2 (show PFDN2 Antibodies)) gene as the candidate upstream modulator of Sncg (show SNCG Antibodies) expression.

  9. The response of CPLX1 (show CPLX1 Antibodies) and Foxp1 (show FOXP1 Antibodies) levels to SNCA deficiency supports the notion that these factors are regulated by altered physiological function of alpha-synuclein.

  10. The pattern of expression and distribution of alpha-synuclein during the development of ciliary body and iris of mice, chick and fish data concluded that alpha-synuclein has important cellular function during eye development of studied animals.

Human Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) interaction partners

  1. Findings indicate that alpha-synuclein pathology in the peripheral nerves is axonal-predominant in Lewy body disease, whereas it is restricted to glial cells in multiple system atrophy.

  2. The subgroup of PD showed higher levels of CSF (show CSF2 Antibodies) alpha-synuclein (38.3 +/- 17.8 ng/ml) than the rest (25.3 +/- 11.3 ng/ml, P = 0.012). These results suggest that PD (and MSA (show TPO Antibodies)) includes two subgroups, which show different metabolism of CSF (show CSF2 Antibodies) transferrin (show Tf Antibodies) and alpha-synuclein.

  3. Programmed cell death protein 1 (PD1 (show PDCD1 Antibodies)) and programmed death-ligand 1 (PDL1 (show CD274 Antibodies)) status by immunohistochemistry was not associated with outcomes. The use of immune checkpoint blockade in tumors with higher mutational load was associated with improved OS. Our results suggest that the evaluation of tumor genomes may be predictive of immunotherapy benefit

  4. SNCA variant carriers with have more favorable treatment responses to deep brain stimulation.

  5. This study demonstrateed that the rs11931074 in SNCA association with PD risk in Iran population.

  6. extent of phosphorylated alpha-synuclein-immunoreactive astrocytes was correlated with disease durationfa

  7. the 5'-UTR (show UTS2R Antibodies) is an important positive regulator of SNCA synthesis under diverse physiological and pathological conditions.

  8. Intrinsic and membrane-facilitated alpha-synuclein oligomerization characteristic of Parkinson's disease has been revealed in model systems in solution.

  9. The findings of this study add further data showing that common variants in SNCA and MAPT (show MAPT Antibodies) genes contribute to variability in progression of parkinson disease.

  10. The interaction of alpha synuclein with a liquid-disordering phospholipid uniquely enriched in mitochondrial membranes helps target alpha-synuclein oligomeric complexes intracellularly to mitochondria. [review]

Cow (Bovine) Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) interaction partners

  1. analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (show TNFAIP1 Antibodies) [ANXB12]

  2. Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.

Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) Antigen Profile

Protein Summary

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Gene names and symbols associated with SNCA

  • synuclein, alpha (non A4 component of amyloid precursor) (SNCA) antibody
  • alpha-synuclein (LOC100359228) antibody
  • alpha-synuclein-like (SNCA) antibody
  • synuclein, alpha (Snca) antibody
  • synuclein, alpha (non A4 component of amyloid precursor) (Snca) antibody
  • alphaSYN antibody
  • NACP antibody
  • PARK1 antibody
  • PARK4 antibody
  • PD1 antibody

Protein level used designations for SNCA

alpha SYN , alpha-synuclein , non-A beta component of AD amyloid , non-A4 component of amyloid , non A-beta component of AD amyloid , synuclein alpha-140 , alpha synuclein

GENE ID SPECIES
100053270 Equus caballus
100359228 Oryctolagus cuniculus
706985 Macaca mulatta
20617 Mus musculus
6622 Homo sapiens
29219 Rattus norvegicus
478478 Canis lupus familiaris
282857 Bos taurus
641350 Sus scrofa
395393 Gallus gallus
100725375 Cavia porcellus
100294604 Ovis aries
100190854 Pongo abelii
461375 Pan troglodytes
100984304 Pan paniscus
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