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Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein.
Overexpression of mutant alpha-synuclein causes age-dependent pathological changes in brain.
alpha-synuclein may have a varying modulating effect on the growth dynamics and the fate of populations of DA neurons.
In the olfactory bulb, globus pallidus and substantia nigra pars (show EPRS ELISA Kits) compacta, alpha-synuclein was expressed, but not in the cerebral cortex, subthalamic nucleus or thalamus.
identified alpha-synuclein as a new transcriptional target of p53 (show TP53 ELISA Kits)
High SNCA expression is associated with epilepsy.
Data suggest the produced mouse lines represent a set of useful tools for studies of alpha-synuclein normal function and the role of this protein in disease pathogenesis.
that loss of glucocerebrosidase (show GBA ELISA Kits) function may contribute to SNCA accumulation through inhibition of autophagy via PPP2A inactivation
provides evidence for a novel interaction of alpha-synuclein and SOD1 (show SOD1 ELISA Kits) that might be relevant for neurodegenerative diseases
It found that chromosome 1 harbors an expression quantitative trait locus that modulates Sncg (show SNCG ELISA Kits) expression in the mouse retina, and identified the prefoldin-2 (PFDN2 (show PFDN2 ELISA Kits)) gene as the candidate upstream modulator of Sncg (show SNCG ELISA Kits) expression.
The response of CPLX1 (show CPLX1 ELISA Kits) and Foxp1 (show FOXP1 ELISA Kits) levels to SNCA deficiency supports the notion that these factors are regulated by altered physiological function of alpha-synuclein.
The pattern of expression and distribution of alpha-synuclein during the development of ciliary body and iris of mice, chick and fish data concluded that alpha-synuclein has important cellular function during eye development of studied animals.
Findings indicate that alpha-synuclein pathology in the peripheral nerves is axonal-predominant in Lewy body disease, whereas it is restricted to glial cells in multiple system atrophy.
The subgroup of PD showed higher levels of CSF (show CSF2 ELISA Kits) alpha-synuclein (38.3 +/- 17.8 ng/ml) than the rest (25.3 +/- 11.3 ng/ml, P = 0.012). These results suggest that PD (and MSA (show TPO ELISA Kits)) includes two subgroups, which show different metabolism of CSF (show CSF2 ELISA Kits) transferrin (show Tf ELISA Kits) and alpha-synuclein.
Programmed cell death protein 1 (PD1 (show PDCD1 ELISA Kits)) and programmed death-ligand 1 (PDL1 (show CD274 ELISA Kits)) status by immunohistochemistry was not associated with outcomes. The use of immune checkpoint blockade in tumors with higher mutational load was associated with improved OS. Our results suggest that the evaluation of tumor genomes may be predictive of immunotherapy benefit
SNCA variant carriers with have more favorable treatment responses to deep brain stimulation.
This study demonstrateed that the rs11931074 in SNCA association with PD risk in Iran population.
extent of phosphorylated alpha-synuclein-immunoreactive astrocytes was correlated with disease durationfa
the 5'-UTR (show UTS2R ELISA Kits) is an important positive regulator of SNCA synthesis under diverse physiological and pathological conditions.
Intrinsic and membrane-facilitated alpha-synuclein oligomerization characteristic of Parkinson's disease has been revealed in model systems in solution.
The findings of this study add further data showing that common variants in SNCA and MAPT (show MAPT ELISA Kits) genes contribute to variability in progression of parkinson disease.
The interaction of alpha synuclein with a liquid-disordering phospholipid uniquely enriched in mitochondrial membranes helps target alpha-synuclein oligomeric complexes intracellularly to mitochondria. [review]
analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (show TNFAIP1 ELISA Kits) [ANXB12]
Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
, non-A beta component of AD amyloid
, non-A4 component of amyloid
, non A-beta component of AD amyloid
, synuclein alpha-140
, alpha synuclein