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Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein.
Overexpression of mutant alpha-synuclein causes age-dependent pathological changes in brain.
Data suggest the produced mouse lines represent a set of useful tools for studies of alpha-synuclein normal function and the role of this protein in disease pathogenesis.
that loss of glucocerebrosidase (show GBA ELISA Kits) function may contribute to SNCA accumulation through inhibition of autophagy via PPP2A inactivation
provides evidence for a novel interaction of alpha-synuclein and SOD1 (show SOD1 ELISA Kits) that might be relevant for neurodegenerative diseases
It found that chromosome 1 harbors an expression quantitative trait locus that modulates Sncg (show SNCG ELISA Kits) expression in the mouse retina, and identified the prefoldin-2 (PFDN2 (show PFDN2 ELISA Kits)) gene as the candidate upstream modulator of Sncg (show SNCG ELISA Kits) expression.
The response of CPLX1 (show CPLX1 ELISA Kits) and Foxp1 (show FOXP1 ELISA Kits) levels to SNCA deficiency supports the notion that these factors are regulated by altered physiological function of alpha-synuclein.
The pattern of expression and distribution of alpha-synuclein during the development of ciliary body and iris of mice, chick and fish data concluded that alpha-synuclein has important cellular function during eye development of studied animals.
Longitudinal Metabolomics Profiling of Parkinson's Disease-Related alpha-Synuclein A53T Transgenic Mice.
This would suggest that as complex I-deficient cells have already adapted to their mitochondrial defect, the subsequent toxic effects of alpha-synuclein are reduced.
The temporal expression pattern of alpha-synuclein modulates olfactory neurogenesis in transgenic mice and has an important role.
These findings support a reciprocal modulatory interaction of alpha-syn and synapsin III (show SYN3 ELISA Kits) in the regulation of dopamine neuron synaptic function.
Samples were taken from six sites and immunostained for phosphorylated alpha-synuclein
This study deminstrated that alpha-Synuclein methylation levels depended on disease status, sex, age, and the genotype of rs3756063.
HMGB1 (show HMGB1 ELISA Kits) or Beclin1 (show BECN1 ELISA Kits) upregulate alpha-synuclein degradation, ameliorating alpha-synuclein-mediated autophagy reduction in PC12 cells.
his study showed that decreased Levels of monomeric Alpha-Synuclein correlate with Duration of Dementia.
Chemical cross-linking in combination with solution-state NMR and multiangle static light scattering (MALS (show NCR3 ELISA Kits)) of alpha-Syn particles reveal a high-order protein-lipid entity composed of approximately 8-10 alpha-Syn molecules.
Results imply that accumulating alpha-synuclein severely affects hippocampal neurogenesis paralleled by impaired 5-HT (show DDC ELISA Kits) neurotransmission prior to the onset of aggregation pathology and overt motor deficits in a transgenic rat Parkinson's disease model
utility of alpha-synuclein as biofluid marker in neurodegenerative diseases
single-molecule Forster Resonance Energy Transfer to visualize directly the protein self-assembly process by wild-type alpha-synuclein and A53T, A30P and E46K mutants and to compare the structural properties of the ensemble of oligomers generated.
An alpha-synuclein mutant inhibited two forms of endocytosis, slow and rapid, in central nerve terminals.
analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (show TNFAIP1 ELISA Kits) [ANXB12]
Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
, non-A beta component of AD amyloid
, non-A4 component of amyloid
, non A-beta component of AD amyloid
, synuclein alpha-140
, alpha synuclein