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Synuclein, alpha Proteins (SNCA)

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Additionally we are shipping SNCA Antibodies (651) and SNCA Kits (55) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SNCA 20617 O55042
SNCA 6622 P37840
SNCA 29219 P37377
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Top SNCA Proteins at antibodies-online.com

Showing 10 out of 71 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 9 to 11 Days
$217.80
Details
Rabbit Rat Un-conjugated Indirect immunostaining of hippocampus neurons (dilution 1 : 500). 200 μL Log in to see 5 to 6 Days
$358.05
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 16 Days
$195.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 7 to 9 Days
$358.57
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 100 μg Log in to see 7 to 8 Days
$319.00
Details
Yeast Macaca fascicularis His tag Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) (AA 1-140), (full length) protein (His tag) 500 μg Log in to see 56 to 66 Days
$1,155.00
Details
Yeast Rat His tag Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) (AA 1-140) protein (His tag) expressed in E. coli 1 mg Log in to see 56 to 66 Days
$2,299.00
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$154.00
Details

SNCA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , ,
, , ,
Rat (Rattus) , ,

Top referenced SNCA Proteins

  1. Mouse (Murine) SNCA Protein expressed in Escherichia coli (E. coli) - ABIN667142 : Kim: Evidence that the precursor protein of non-A beta component of Alzheimer's disease amyloid (NACP) has an extended structure primarily composed of random-coil. in Molecules and cells 1997 (PubMed)
    Show all 3 references for ABIN667142

  2. Human SNCA Protein expressed in Escherichia coli (E. coli) - ABIN1046507 : Uéda, Fukushima, Masliah, Xia, Iwai, Yoshimoto, Otero, Kondo, Ihara, Saitoh: Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Show all 3 references for ABIN1046507

  3. Human SNCA Protein expressed in Escherichia coli (E. coli) - ABIN2005039 : Lee, Choi, Lee: Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for ABIN2005039

  4. Rat (Rattus) SNCA Protein expressed in Rabbit - ABIN1742284 : Jüttner, Moré, Das, Babich, Meier, Henning, Erdmann, Mu Ller, Otto, Grantyn, Rathjen: Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity. in Neuron 2005 (PubMed)

More Proteins for Synuclein, alpha (SNCA) Interaction Partners

Xenopus laevis Synuclein, alpha (SNCA) interaction partners

  1. study examined the spatial and temporal expression patterns of three synuclein genes (snca, sncbb, sncg (show SNCG Proteins)) during embryogenesis

Mouse (Murine) Synuclein, alpha (SNCA) interaction partners

  1. alpha-synuclein may have a varying modulating effect on the growth dynamics and the fate of populations of DA neurons.

  2. In the olfactory bulb, globus pallidus and substantia nigra pars compacta, alpha-synuclein was expressed, but not in the cerebral cortex, subthalamic nucleus or thalamus.

  3. identified alpha-synuclein as a new transcriptional target of p53 (show TP53 Proteins)

  4. High SNCA expression is associated with epilepsy.

  5. Data suggest the produced mouse lines represent a set of useful tools for studies of alpha-synuclein normal function and the role of this protein in disease pathogenesis.

  6. that loss of glucocerebrosidase function may contribute to SNCA accumulation through inhibition of autophagy via PPP2A inactivation

  7. provides evidence for a novel interaction of alpha-synuclein and SOD1 (show SOD1 Proteins) that might be relevant for neurodegenerative diseases

  8. It found that chromosome 1 harbors an expression quantitative trait locus that modulates Sncg (show SNCG Proteins) expression in the mouse retina, and identified the prefoldin-2 (PFDN2 (show PFDN2 Proteins)) gene as the candidate upstream modulator of Sncg (show SNCG Proteins) expression.

  9. The response of CPLX1 and Foxp1 levels to SNCA deficiency supports the notion that these factors are regulated by altered physiological function of alpha-synuclein.

  10. The pattern of expression and distribution of alpha-synuclein during the development of ciliary body and iris of mice, chick and fish data concluded that alpha-synuclein has important cellular function during eye development of studied animals.

Human Synuclein, alpha (SNCA) interaction partners

  1. Findings indicate that alpha-synuclein pathology in the peripheral nerves is axonal-predominant in Lewy body disease, whereas it is restricted to glial cells in multiple system atrophy.

  2. The subgroup of PD showed higher levels of CSF alpha-synuclein (38.3 +/- 17.8 ng/ml) than the rest (25.3 +/- 11.3 ng/ml, P = 0.012). These results suggest that PD (and MSA) includes two subgroups, which show different metabolism of CSF transferrin and alpha-synuclein.

  3. Programmed cell death protein 1 (PD1 (show PDCD1 Proteins)) and programmed death-ligand 1 (PDL1 (show CD274 Proteins)) status by immunohistochemistry was not associated with outcomes. The use of immune checkpoint blockade in tumors with higher mutational load was associated with improved OS. Our results suggest that the evaluation of tumor genomes may be predictive of immunotherapy benefit

  4. SNCA variant carriers with have more favorable treatment responses to deep brain stimulation.

  5. This study demonstrateed that the rs11931074 in SNCA association with PD risk in Iran population.

  6. extent of phosphorylated alpha-synuclein-immunoreactive astrocytes was correlated with disease durationfa

  7. the 5'-UTR is an important positive regulator of SNCA synthesis under diverse physiological and pathological conditions.

  8. Intrinsic and membrane-facilitated alpha-synuclein oligomerization characteristic of Parkinson's disease has been revealed in model systems in solution.

  9. The findings of this study add further data showing that common variants in SNCA and MAPT (show MAPT Proteins) genes contribute to variability in progression of parkinson disease.

  10. The interaction of alpha synuclein with a liquid-disordering phospholipid uniquely enriched in mitochondrial membranes helps target alpha-synuclein oligomeric complexes intracellularly to mitochondria. [review]

Cow (Bovine) Synuclein, alpha (SNCA) interaction partners

  1. analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (show TNFAIP1 Proteins) [ANXB12]

  2. Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.

SNCA Protein Profile

Protein Summary

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Gene names and symbols associated with Synuclein, alpha Proteins (SNCA)

  • synuclein, alpha (snca)
  • alpha-synuclein (LOC619283)
  • alpha-synuclein (LOC100359228)
  • synuclein, alpha (Snca)
  • synuclein, alpha (non A4 component of amyloid precursor) (SNCA)
  • synuclein, alpha (non A4 component of amyloid precursor) (Snca)
  • alphaSYN protein
  • LOC619283 protein
  • MGC64356 protein
  • NACP protein
  • PARK1 protein
  • PARK4 protein
  • PD1 protein
  • snca protein

Protein level used designations for Synuclein, alpha Proteins (SNCA)

synuclein, alpha , alpha-synuclein , alpha SYN , non-A beta component of AD amyloid , non-A4 component of amyloid , non A-beta component of AD amyloid , synuclein alpha-140 , alpha synuclein

GENE ID SPECIES
380315 Xenopus laevis
619283 Takifugu rubripes
100359228 Oryctolagus cuniculus
20617 Mus musculus
6622 Homo sapiens
29219 Rattus norvegicus
641350 Sus scrofa
282857 Bos taurus
395393 Gallus gallus
100294604 Ovis aries
Selected quality suppliers for SNCA Proteins (SNCA)
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