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Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Additionally we are shipping SNCA Antibodies (651) and SNCA Kits (55) and many more products for this protein.
Showing 10 out of 71 products:
Mouse (Murine) SNCA Protein expressed in Escherichia coli (E. coli) - ABIN667142
Kim: Evidence that the precursor protein of non-A beta component of Alzheimer's disease amyloid (NACP) has an extended structure primarily composed of random-coil. in Molecules and cells 1997
Show all 3 references for ABIN667142
Human SNCA Protein expressed in Escherichia coli (E. coli) - ABIN1046507
Uéda, Fukushima, Masliah, Xia, Iwai, Yoshimoto, Otero, Kondo, Ihara, Saitoh: Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. in Proceedings of the National Academy of Sciences of the United States of America 1994
Show all 3 references for ABIN1046507
Human SNCA Protein expressed in Escherichia coli (E. coli) - ABIN2005039
Lee, Choi, Lee: Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. in The Journal of biological chemistry 2002
Show all 2 references for ABIN2005039
Rat (Rattus) SNCA Protein expressed in Rabbit - ABIN1742284
Jüttner, Moré, Das, Babich, Meier, Henning, Erdmann, Mu Ller, Otto, Grantyn, Rathjen: Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity. in Neuron 2005
study examined the spatial and temporal expression patterns of three synuclein genes (snca, sncbb, sncg (show SNCG Proteins)) during embryogenesis
alpha-synuclein may have a varying modulating effect on the growth dynamics and the fate of populations of DA neurons.
In the olfactory bulb, globus pallidus and substantia nigra pars compacta, alpha-synuclein was expressed, but not in the cerebral cortex, subthalamic nucleus or thalamus.
identified alpha-synuclein as a new transcriptional target of p53 (show TP53 Proteins)
High SNCA expression is associated with epilepsy.
Data suggest the produced mouse lines represent a set of useful tools for studies of alpha-synuclein normal function and the role of this protein in disease pathogenesis.
that loss of glucocerebrosidase function may contribute to SNCA accumulation through inhibition of autophagy via PPP2A inactivation
provides evidence for a novel interaction of alpha-synuclein and SOD1 (show SOD1 Proteins) that might be relevant for neurodegenerative diseases
It found that chromosome 1 harbors an expression quantitative trait locus that modulates Sncg (show SNCG Proteins) expression in the mouse retina, and identified the prefoldin-2 (PFDN2 (show PFDN2 Proteins)) gene as the candidate upstream modulator of Sncg (show SNCG Proteins) expression.
The response of CPLX1 and Foxp1 levels to SNCA deficiency supports the notion that these factors are regulated by altered physiological function of alpha-synuclein.
The pattern of expression and distribution of alpha-synuclein during the development of ciliary body and iris of mice, chick and fish data concluded that alpha-synuclein has important cellular function during eye development of studied animals.
Findings indicate that alpha-synuclein pathology in the peripheral nerves is axonal-predominant in Lewy body disease, whereas it is restricted to glial cells in multiple system atrophy.
The subgroup of PD showed higher levels of CSF alpha-synuclein (38.3 +/- 17.8 ng/ml) than the rest (25.3 +/- 11.3 ng/ml, P = 0.012). These results suggest that PD (and MSA) includes two subgroups, which show different metabolism of CSF transferrin and alpha-synuclein.
Programmed cell death protein 1 (PD1 (show PDCD1 Proteins)) and programmed death-ligand 1 (PDL1 (show CD274 Proteins)) status by immunohistochemistry was not associated with outcomes. The use of immune checkpoint blockade in tumors with higher mutational load was associated with improved OS. Our results suggest that the evaluation of tumor genomes may be predictive of immunotherapy benefit
SNCA variant carriers with have more favorable treatment responses to deep brain stimulation.
This study demonstrateed that the rs11931074 in SNCA association with PD risk in Iran population.
extent of phosphorylated alpha-synuclein-immunoreactive astrocytes was correlated with disease durationfa
the 5'-UTR is an important positive regulator of SNCA synthesis under diverse physiological and pathological conditions.
Intrinsic and membrane-facilitated alpha-synuclein oligomerization characteristic of Parkinson's disease has been revealed in model systems in solution.
The findings of this study add further data showing that common variants in SNCA and MAPT (show MAPT Proteins) genes contribute to variability in progression of parkinson disease.
The interaction of alpha synuclein with a liquid-disordering phospholipid uniquely enriched in mitochondrial membranes helps target alpha-synuclein oligomeric complexes intracellularly to mitochondria. [review]
analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (show TNFAIP1 Proteins) [ANXB12]
Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
, alpha SYN
, non-A beta component of AD amyloid
, non-A4 component of amyloid
, non A-beta component of AD amyloid
, synuclein alpha-140
, alpha synuclein